Correlations Between Trabecular Bone Score, Measured Using Anteroposterior Dual-Energy X-Ray Absorptiometry Acquisition, and 3-Dimensional Parameters of Bone Microarchitecture: An Experimental Study on Human Cadaver Vertebrae

Hans, Didier; Barthe, Nicole; Boutroy, Stéphanie; Pothuaud, Laurent; Winzenrieth, Renaud; Krieg, Marc‐Antoine

doi:10.1016/j.jocd.2011.05.005

Cited by 367 publications

(279 citation statements)

References 30 publications

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“…(18,19) At variance, since the measurement of TBS can be obtained by 2D projection images acquired during a conventional lumbar spine scan, TBS may be used routinely for evaluating bone microarchitecture. (20)(21)(22) Indeed, previous studies demonstrated that TBS is strongly correlated with bone microarchitecture, regardless of BMD, (23) and documented the added value of TBS in bone mineral densitometry for fracture risk assessment in postmenopausal osteoporosis. (24)(25)(26)(27) We found that TBS, but not LS-BMD, is associated with prevalent vertebral fractures regardless of age, BMI, and gender.…”

Section: Discussionmentioning

confidence: 99%

“…(20)(21)(22) TBS has been demonstrated to be strongly correlated with bone microarchitecture, regardless of BMD, (23) and several studies (24)(25)(26) have documented the added value of TBS in bone mineral densitometry for fracture risk assessment in postmenopausal osteoporosis. (22)(23)(24)(25)(26)(27) Few data are available regarding TBS in patients with glucocorticoid induced osteoporosis, (28,29) and no studies evaluated bone microarchitecture by TBS in SH patients.…”

Section: Introductionmentioning

confidence: 99%

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Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism

Eller-Vainicher

Morelli

Ulivieri

et al. 2012

Journal of Bone and Mineral Research

127

128

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Patients with adrenal incidentalomas (AIs) and subclinical hypercortisolism (SH) have increased risk of fracture independent of bone mineral density (BMD) and possibly due to reduced bone quality. The trabecular bone score (TBS) has been proposed as a index of bone microarchitecture. The aim of the study was to investigate TBS in AI. In 102 AI patients, SH was diagnosed in the presence of at least two of the following: (1) urinary free cortisol >70 mg/24 h (193.1 nmol/L); (2) cortisol after 1-mg dexamethasone suppression test (1-mg DST) >3.0 mg/dL (82.8 nmol/L); or (3) adrenocorticotropic hormone (ACTH) <10 pg/mL (<2.2 pmol/L). In patients and in 70 matched controls, BMD was measured at lumbar spine (LS) and femur (neck [FN] and total [FT]) by dual X-ray absorptiometry and TBS was assessed in the region of LS-BMD; BMD and TBS data were reported as Z-scores. In patients, vertebral deformities were assessed by radiograph. Patients with SH (n ¼ 34) had lower LS-BMD (À0.31 AE 1.17), FT-BMD (À0.29 AE 0.91), and TBS (À3.18 AE 1.21) than patients without SH (n ¼ 68, 0.31 AE 1.42, p ¼ 0.03; 0.19 AE 0.97, p ¼ 0.01; À1.70 AE 1.54, p < 0.0001, respectively) and controls (0.42 AE 1.52, p ¼ 0.02; 0.14 AE 0.76, p ¼ 0.02; À1.19 AE 0.99, p < 0.0001, respectively). TBS was inversely correlated with 1-mg DST (b ¼ À0.26, t ¼ À2.79, p ¼ 0.006) regardless of age, LS-BMD, body mass index (BMI), and gender. The presence of fracture was associated with low TBS alone (odds ratio [OR], 4.8; 95% confidence interval [CI], 1.85-12.42, p ¼ 0.001) and with the cluster low TBS plus low LS-BMD (OR, 4.37; 95% CI, 1.71-11.4, p ¼ 0.002), after adjustment for age, BMI, and gender. Low TBS plus low LS-BMD showed a good specificity (79%) for predicting fractures, whereas normal TBS (ie, > À1.5) plus normal LS-BMD high specificity (88.1%) for excluding fractures. Finally, TBS predicted the occurrence of a new fracture in 40 patients followed for 24 months (OR, 11.2; 95%CI, 1.71-71.41, p ¼ 0.012) regardless of LS-BMD, BMI, and age. In SH, bone quality, as measured by TBS, is altered. TBS is useful in detecting AI patients at risk of fractures. ß

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism

Eller-Vainicher

Morelli

Ulivieri

et al. 2012

Journal of Bone and Mineral Research

127

128

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“…(21) Its primary value beyond BMD is that it may specifically assess some dimensions of vertebral bone microarchitectural texture, which is recognized to be an important determinant of bone strength independent of BMD. ( (17,18) and mCT (35 mm). (32) Correlations remained significant even at low resolution.…”

Section: Discussionmentioning

confidence: 99%

“…(16,17) TBS values, as evaluated from 2D projection DXA images, demonstrate highly significant correlations with the 3D characteristics of trabecular bone microarchitecture, independent of BMD. (16)(17)(18) A low TBS value has been found to be associated with degraded bone microarchitecture, low connectivity, high trabecular spacing, and a reduced number of trabeculae; conversely, a high TBS value has been found to be associated with good bone microarchitecture, including high connectivity, low trabecular spacing, and an augmented number of trabeculae. (17,18) Hence, high values of TBS reflect strong, fracture-resistant microarchitecture, whereas low TBS reflects weak, fracture-prone microarchitecture.…”

Section: Introductionmentioning

confidence: 99%

“…(16)(17)(18) A low TBS value has been found to be associated with degraded bone microarchitecture, low connectivity, high trabecular spacing, and a reduced number of trabeculae; conversely, a high TBS value has been found to be associated with good bone microarchitecture, including high connectivity, low trabecular spacing, and an augmented number of trabeculae. (17,18) Hence, high values of TBS reflect strong, fracture-resistant microarchitecture, whereas low TBS reflects weak, fracture-prone microarchitecture. (16,17,19,20) Cancellous bone microarchitectural texture assessed by TBS was a predictor of osteoporotic fracture risk independent of spine and hip BMD in a retrospectively analyzed prospective cohort of 29,407 women, age 50 years or more, living in the Province of Manitoba, Canada.…”

Section: Introductionmentioning

confidence: 99%

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Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study

Popp

Guler

Lamy

et al. 2012

Journal of Bone and Mineral Research

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The trabecular bone score (TBS) is an index of bone microarchitectural texture calculated from anteroposterior dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (LS) that predicts fracture risk, independent of bone mineral density (BMD). The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) on LS BMD and TBS in postmenopausal women with osteoporosis. Changes in TBS were assessed in the subset of 107 patients recruited at the Department of Osteoporosis of the University Hospital of Berne, Switzerland, who were included in the HORIZON trial. All subjects received adequate calcium and vitamin D3. In these patients randomly assigned to either ZOL (n ¼ 54) or PLB (n ¼ 53) for 3 years, BMD was measured by DXA and TBS assessed by TBS iNsight (v1.9) at baseline and 6, 12, 24, and 36 months after treatment initiation. Baseline characteristics (mean AE SD) were similar between groups in terms of age, 76.8 AE 5.0 years; body mass index (BMI), 24.5 AE 3.6 kg/m 2 ; TBS, 1.178 AE 0.1 but for LS T-score (ZOL-2.9 AE 1.5 versus PLB-2.1 AE 1.5). Changes in LS BMD were significantly greater with ZOL than with PLB at all time points (p < 0.0001 for all), reaching þ9.58% versus þ1.38% at month 36. Change in TBS was significantly greater with ZOL than with PLB as of month 24, reaching þ1.41 versus-0.49% at month 36; p ¼ 0.031, respectively. LS BMD and TBS were weakly correlated (r ¼ 0.20) and there were no correlations between changes in BMD and TBS from baseline at any visit. In postmenopausal women with osteoporosis, once-yearly intravenous ZOL therapy significantly increased LS BMD relative to PLB over 3 years and TBS as of 2 years. ß

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Trabecular Bone Score

Silva

Leslie

2018

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Correlations Between Trabecular Bone Score, Measured Using Anteroposterior Dual-Energy X-Ray Absorptiometry Acquisition, and 3-Dimensional Parameters of Bone Microarchitecture: An Experimental Study on Human Cadaver Vertebrae

Cited by 367 publications

References 30 publications

Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism

Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism

Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study

Trabecular Bone Score

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