2007
DOI: 10.1016/j.jbiomech.2007.03.014
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Correlations between tissue-level stresses and strains and cellular damage within the guinea pig spinal cord white matter

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Cited by 33 publications
(44 citation statements)
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“…In this study, pressure, maximum principal stresses, and maximum principal strains showed a propensity for the highest values to occur in the central cord. This agrees well with a recent study showing maximum principal stress to correlate with injury in the white matter (Galle et al, 2007). The results of our study suggest that patterns of injury (and resulting deficits) will change with variations in material characteristics resulting from aging or disease.…”
Section: Figsupporting
confidence: 93%
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“…In this study, pressure, maximum principal stresses, and maximum principal strains showed a propensity for the highest values to occur in the central cord. This agrees well with a recent study showing maximum principal stress to correlate with injury in the white matter (Galle et al, 2007). The results of our study suggest that patterns of injury (and resulting deficits) will change with variations in material characteristics resulting from aging or disease.…”
Section: Figsupporting
confidence: 93%
“…Our results suggest that studies modeling blood flow in the spinal cord require, as a minimum, accurate white matter properties. Conversely, strain measures in the white matter have been correlated with functional losses (Galbraith et al, 1993;Galle et al, 2007). For the type of compression loading between rigid platens that was simulated here, our results show that finite element models using strains as outcome measures are robust to variations in all material properties.…”
mentioning
confidence: 73%
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“…Often small animals, like mice or rats, are exposed to the product for a longer periods of time (Wagner et al, 2006;Lee et al, 2007) or for shorter periods of time to assess acute effects (Dong et al, 2005;Kouadio et al, 2005). As in human trials (De Backer et al, 2007a) a trend is emerging in animal studies towards accurate computer models describing the animals' physiological behavior (Schroeter et al, 2006;Galle et al, 2007). Although never entirely replacing animal studies, this could, eventually, reduce the amount of animals needed for research.…”
mentioning
confidence: 99%
“…The resulting stress and deformation of the spinal cord is a major cause of neurological deficit and loss of motor and sensory function in patients with traumatic SCI [4]. The size of deformation, strain rate, size of axons and the local stress state in tissue have been proposed as the primary mechanism of damage to the spinal cord parenchyma cells during an injury [5]. Morbidities, such as degeneration, tumors, or cancers, can also cause the compression of the spinal tissue leading to its destruction.…”
Section: Introductionmentioning
confidence: 99%