Correlations between the CagA Antigen and Serum Levels of Anti-<i>Helicobacter pylori</i>IgG and IgA in Children

Seo, Ji‐Hyun; Lim, Chun Woo; Park, Ji Sook; Yeom, Jung Sook; Lim, Jae Young; Jun, Jin Su; Woo, Hyang Ok; Youn, Hee Shang; Baik, Seung‐Chul; Lee, Woo Kon; Cho, Myung Je; Rhee, Kwang Ho

doi:10.3346/jkms.2016.31.3.417

Cited by 11 publications

(17 citation statements)

References 31 publications

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“…Nonetheless, it can be assumed that the findings of these 2 tests would not vary, because they exhibit a similar accuracy and a high concurrence rate compared with the Korean H. pylori IgG assay (13). Our study findings can be also supported by a recent study which showed that the serum anti- H. pylori IgG and IgA levels correlate well with the positive findings of the urease test and anti-CagA protein antibody test as well as the degrees of gastritis and H. pylori infiltration (23). …”

Section: Discussionsupporting

confidence: 89%

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Lee

Kim

et al. 2017

J Korean Med Sci

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The serum pepsinogen (PG) assay findings are correlated with the status of Helicobacter pylori infection, but there are controversies on the link with upper gastrointestinal (UGI) endoscopic findings. The aim of this study was to determine the significance of a serum PG assay for correlating with endoscopic findings in H. pylori-seroprevalent adult population. Korean adults who visited for a health check-up were included consecutively. Subjects after gastrectomy or H. pylori eradication were excluded. After completing the serum PG assay and anti-H. pylori immunoglobulin G (IgG) titer on the same day of UGI endoscopy, subjects with equivocal serology test finding or gastric neoplasm were excluded. Of the 4,830 included subjects, 3,116 (64.5%) were seropositive for H. pylori. Seropositive finding was related to high serum PG I (P < 0.001) and PG II (P < 0.001) concentrations, low PG I/II ratio (P < 0.001), old age (P < 0.001), and male gender (P = 0.006). After adjusting age and gender, the serum PG I and II concentrations were positively correlated with the presence of nodular gastritis (NG) (all P = 0.003). The serum PG I was positively correlated with gastric ulcer (P = 0.003), and it was correlated with duodenal ulcer in seropositive subjects (P = 0.008). The PG I/II ratio was positively correlated with erosive esophagitis, while it was inversely related to chronic atrophic gastritis and metaplastic gastritis (all P < 0.001). Our findings suggest that the serum PG assay finding correlates well with the UGI endoscopic finding. A higher serum PG concentration in subjects with NG and peptic ulcer disease suggests that endoscopic findings reflect gastric secreting ability.

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Section: Discussionsupporting

confidence: 89%

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Lee

Kim

et al. 2017

J Korean Med Sci

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“…They demonstrated that the anti‐ H. pylori IgG and IgA antibody titers were higher in the sera of CagA‐positive children regardless of age, while IgG and IgA titers increased with chronic gastritis degree, active gastritis, H. pylori infiltration, RUT grade, and older age. Presence of CagA‐positivity was correlated with a high urease test grade and high anti‐ H. pylori IgG/IgA levels …”

Section: Diagnosismentioning

confidence: 95%

“…More precisely, Seo et al. searched correlations between anti‐ H. pylori IgG and IgA levels and the RUT, anti‐CagA antibodies, degree of gastritis, and age in 509 children stratified by age . They demonstrated that the anti‐ H. pylori IgG and IgA antibody titers were higher in the sera of CagA‐positive children regardless of age, while IgG and IgA titers increased with chronic gastritis degree, active gastritis, H. pylori infiltration, RUT grade, and older age.…”

Section: Diagnosismentioning

confidence: 99%

“…33 In another study, the same authors using H. pylori-specific IgG by ELISA in urine compared to serum H. pylori IgG-ELISA as the gold standard, reported sensitivity, specificity, PPV, and NPV of rapid urine antibody test of 85.7%, 100%, 100%, and 99.4%. 34 More precisely, Seo et al 35 searched correlations between anti-H. pylori IgG and IgA levels and the RUT, anti-CagA antibodies, degree of gastritis, and age in 509 children stratified by age. 35 They demonstrated that the anti-H. pylori IgG and IgA antibody titers were higher in the sera of 36 Lash et al 37 carried out a study designed to test the hypothesis that hematoxylin and eosin stain and special immunohistochemical stains (IHC) have similar sensitivity and that IHC only marginally enhances the detection rate of the organisms.…”

Section: Helicobacter Pylori Infection and Atopic Manifestationsmentioning

confidence: 99%

“…34 More precisely, Seo et al 35 searched correlations between anti-H. pylori IgG and IgA levels and the RUT, anti-CagA antibodies, degree of gastritis, and age in 509 children stratified by age. 35 They demonstrated that the anti-H. pylori IgG and IgA antibody titers were higher in the sera of 36 Lash et al 37 carried out a study designed to test the hypothesis that hematoxylin and eosin stain and special immunohistochemical stains (IHC) have similar sensitivity and that IHC only marginally enhances the detection rate of the organisms. A total of 56,955 gastric biopsy sets were stained with IHC stains only and 731,193 with IHC.…”

Section: Helicobacter Pylori Infection and Atopic Manifestationsmentioning

confidence: 99%

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Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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Helicobacter pylori Infection in Pediatric Patients: Update on Diagnosis and Eradication Strategies

et al. 2018

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Helicobacter pylori infection is acquired mainly in childhood and remains an essential cause of peptic ulcer disease and gastric cancer. This article provides commentary on the last ESPGHAN/NASPGHAN guidelines and on publications made after the consensus conference of 2015. The majority of infected children are asymptomatic and pediatric studies do not support a role for H. pylori in functional disorders such as recurrent abdominal pain. The role of H. pylori infection in failure to thrive, children's growth, type I diabetes mellitus (T1DM), and celiac disease remains controversial. The diagnosis of infection should be based on upper-digestive endoscopy with biopsy-based methods. Eradication control after treatment should be based on validated non-invasive tests. Nodular gastritis is the main endoscopic finding of childhood H. pylori infection, but gastroduodenal erosions/ulcers are seen in some children, especially after 10 years of age. When indicated, eradication treatment should be given when good compliance is expected and based on the antimicrobial susceptibility profile.

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Correlations between the CagA Antigen and Serum Levels of Anti-Helicobacter pyloriIgG and IgA in Children

Cited by 11 publications

References 31 publications

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Link between Serum Pepsinogen Concentrations and Upper Gastrointestinal Endoscopic Findings

Helicobacter pylori infection in children

Helicobacter pylori Infection in Pediatric Patients: Update on Diagnosis and Eradication Strategies

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