Correlations between serial CEA levels and surgery in patients with colorectal carcinoma

Midiri, G; Amanti, C.; Benedetti, M.; Caliento, D.; Consorti, Fabrizio; Buono, S. Del; Paola, M. Di

doi:10.1002/jso.2930170406

Journal of Surgical Oncology

1981

DOI: 10.1002/jso.2930170406

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Correlations between serial CEA levels and surgery in patients with colorectal carcinoma

G Midiri¹,

C. Amanti

M. Benedetti³

et al.

Abstract: Nowadays the evaluation of serial carcinoembryonic antigen (CEA) levels represents an important parameter for the prognosis of patients with carcinoma of the large bowel. Changes in CEA values allow the drawing of conclusions regarding the effectiveness of therapy. We have studied 63 patients with colorectal carcinoma that underwent surgical treatment. Serial CEA levels were tested in each patient before surgery and 15 days after. The 53 patients were considered surgically cured; and among these 7 did not have… Show more

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1983

1985

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Cited by 3 publications

References 11 publications

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CEA tissue staining in colorectal cancer patients. A way to improve the usefulness of serial serum CEA evaluation

Midiri¹,

Amanti

Benedetti³

et al. 1985

Cancer

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The evaluation of serial plasma carcinoembryonic antigen (CEA) levels is one of the most important parameter used to establish the prognosis of surgically cured colorectal cancer patients. Carcinoembryonic antigen is particularly useful in the identification of recurrences and metastasis. However, to improve the usefulness of this assay, it would be helpful to accurately determine, if possible, those patients whose cancers produce CEA. The evaluation of the presence of CEA in these cancer specimens by means of immunoperoxidase staining technique does seem to improve the sensitivity of the CEA test. Fifty‐seven patients with colorectal cancer who underwent surgical treatment were studied. Tissue CEA evaluation was correlated with the plasma CEA levels, the pathologic stage and grade, and histologic type of the cancers. Results demonstrate that 66.6% of Dukes' B cancers, 78.9% of Dukes' C, and 77.7% of Dukes' D cancers stained positively for CEA by immunoperoxidase. Thirty of 57 patients with preoperative pathologic plasma CEA levels had positive tissue CEA, whereas 8/57 patients did not. Of patients with a well‐differentiated cancer (G1), 81.4% had positive tissue CEA versus the 64% of G2 and 60% of G3 cancers. The authors conclude that the use of the immunoperoxidase stain to measure CEA in tissue, so that the CEA serum assay may be used in those patients known to produce CEA, results in a major increase in the sensitivity of the test.

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CEA tissue staining in colorectal cancer patients. A way to improve the usefulness of serial serum CEA evaluation

Midiri¹,

Amanti

Benedetti³

et al. 1985

Cancer

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Usefulness of preoperative CEA levels in the assessment of colorectal cancer patient stage

Midiri¹,

Amanti²,

Consorti³

et al. 1983

Journal of Surgical Oncology

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In order to demonstrate a prognostic value of preoperative CEA levels, we have tried to define a correlation between CEA and histologic stage of tumor in 124 patients with colorectal carcinoma. CEA concentration has been evaluated by radioimmunologic assay and the histologic stage following Dukes' classification. The results show a 25.0% positivity rate for patients in stage A, 48.2% for stage B, 61.1% for stage C, and 85.7% for stage D. The mean CEA values are 7.8 ng/ml in the first group, 30.3 ng/ml in the second, 58.1 ng/ml in the third, and 134.3 ng/ml in the last group. Furthermore, we have tried to relate the histopathologic grade of the tumor (G) with CEA levels in 54 patients of the 124. We conclude that preoperative CEA has a prognostic value, and it is useful in the staging of colorectal cancer patients. A low concentration indicates an early stage of the tumor, while a high concentration indicates a wide spread of disease; on the other hand, there are not significant correlations with cancer grading.

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Tissue CEA detection by immunoperoxidase (PAP) test in colorectal polyps: Correlations with the degree of dysplasia

Amanti¹,

Midiri²,

Benedetti³

et al. 1985

Journal of Surgical Oncology

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We study the presence of Carcinoembryonic antigen (CEA) on 39 colorectal polyps by the immunoperoxidase technique. The histological examination demonstrated 15 tubular adenomas, one villous adenoma, two tubulo-villous adenomas, six tubular adenomas with slight dysplasia, one tubular adenoma with moderate dysplasia, four tubular adenomas with severe dysplasia, three tubulo-villous adenomas with severe dysplasia, five tubular adenomas with neoplastic degeneration, and two tubulo-villous adenomas with neoplastic degeneration. Twenty-eight of thirty-nine polyps (71.79%) showed a positive staining reaction for CEA. Regarding the intensity of the reaction (classified as absent or negative [-], slightly positive [+], and markedly positive [+ +]), 11/39 polyps presented a negative reaction (28.21%), 19/39 (48.71%) presented a slight reaction, and 10/39 polyps (25.64%) presented a marked reaction. Results demonstrated a higher intensity of the staining reaction in severely dysplastic polyps and in neoplastic degeneration. In conclusion, it is possible that the presence of CEA can be useful to show an initial cellular restlessness of certain polyps.

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Correlations between serial CEA levels and surgery in patients with colorectal carcinoma

Cited by 3 publications

References 11 publications

CEA tissue staining in colorectal cancer patients. A way to improve the usefulness of serial serum CEA evaluation

CEA tissue staining in colorectal cancer patients. A way to improve the usefulness of serial serum CEA evaluation

Usefulness of preoperative CEA levels in the assessment of colorectal cancer patient stage

Tissue CEA detection by immunoperoxidase (PAP) test in colorectal polyps: Correlations with the degree of dysplasia

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