Correlations between <scp>DWI</scp>, <scp>IVIM,</scp> and <scp>HIF</scp>‐1α expression based on <scp>MRI</scp> and pathology in a murine model of rhabdomyosarcoma

Yin, Zhenzhen; Li, Xiangwen; Tao, Juan; Yang, Yanyu; Fang, Shaobo; Zhang, Zhengyang; Yuan, Yuan; Liu, Huan; Wang, Shaowu

doi:10.1002/mrm.29250

Cited by 5 publications

(1 citation statement)

References 34 publications

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“…In the examined literature cohort, there were 6 studies investigating imaging techniques in murine RMS tumors. Interestingly, the majority of studies have focused on correlation investigations between diffusion-weighted imaging (DWI)/ intravoxel incoherent motion (IVIM) and histopathologic features of murine tumors (43,(107)(108)(109).…”

Section: Imagingmentioning

confidence: 99%

Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside

Martynov,

Dhaka,

Wilke

et al. 2024

Front. Oncol.

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BackgroundRhabdomyosarcoma (RMS) is the most common pediatric soft-tissue malignancy, characterized by high clinicalopathological and molecular heterogeneity. Preclinical in vivo models are essential for advancing our understanding of RMS oncobiology and developing novel treatment strategies. However, the diversity of scholarly data on preclinical RMS studies may challenge scientists and clinicians. Hence, we performed a systematic literature survey of contemporary RMS mouse models to characterize their phenotypes and assess their translational relevance.MethodsWe identified papers published between 01/07/2018 and 01/07/2023 by searching PubMed and Web of Science databases.ResultsOut of 713 records screened, 118 studies (26.9%) were included in the qualitative synthesis. Cell line-derived xenografts (CDX) were the most commonly utilized (n = 75, 63.6%), followed by patient-derived xenografts (PDX) and syngeneic models, each accounting for 11.9% (n = 14), and genetically engineered mouse models (GEMM) (n = 7, 5.9%). Combinations of different model categories were reported in 5.9% (n = 7) of studies. One study employed a virus-induced RMS model. Overall, 40.0% (n = 30) of the studies utilizing CDX models established alveolar RMS (aRMS), while 38.7% (n = 29) were embryonal phenotypes (eRMS). There were 20.0% (n = 15) of studies that involved a combination of both aRMS and eRMS subtypes. In one study (1.3%), the RMS phenotype was spindle cell/sclerosing. Subcutaneous xenografts (n = 66, 55.9%) were more frequently used compared to orthotopic models (n = 29, 24.6%). Notably, none of the employed cell lines were derived from primary untreated tumors. Only a minority of studies investigated disseminated RMS phenotypes (n = 16, 13.6%). The utilization areas of RMS models included testing drugs (n = 64, 54.2%), studying tumorigenesis (n = 56, 47.5%), tumor modeling (n = 19, 16.1%), imaging (n = 9, 7.6%), radiotherapy (n = 6, 5.1%), long-term effects related to radiotherapy (n = 3, 2.5%), and investigating biomarkers (n = 1, 0.8%). Notably, no preclinical studies focused on surgery.ConclusionsThis up-to-date review highlights the need for mouse models with dissemination phenotypes and cell lines from primary untreated tumors. Furthermore, efforts should be directed towards underexplored areas such as surgery, radiotherapy, and biomarkers.

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Section: Imagingmentioning

confidence: 99%

Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside

Martynov,

Dhaka,

Wilke

et al. 2024

Front. Oncol.

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Assessment of Hypoxia in Breast Cancer: Emerging Functional MR Imaging and Spectroscopy Techniques and Clinical Applications

Daimiel Naranjo,

Bhowmik,

Basukala

et al. 2024

Magnetic Resonance Imaging

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Breast cancer is one of the most prevalent forms of cancer affecting women worldwide. Hypoxia, a condition characterized by insufficient oxygen supply in tumor tissues, is closely associated with tumor aggressiveness, resistance to therapy, and poor clinical outcomes. Accurate assessment of tumor hypoxia can guide treatment decisions, predict therapy response, and contribute to the development of targeted therapeutic interventions. Over the years, functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) techniques have emerged as promising noninvasive imaging options for evaluating hypoxia in cancer. Such techniques include blood oxygen level‐dependent (BOLD) MRI, oxygen‐enhanced MRI (OE) MRI, chemical exchange saturation transfer (CEST) MRI, and proton MRS (1H‐MRS). These may help overcome the limitations of the routinely used dynamic contrast‐enhanced (DCE) MRI and diffusion‐weighted imaging (DWI) techniques, contributing to better diagnosis and understanding of the biological features of breast cancer. This review aims to provide a comprehensive overview of the emerging functional MRI and MRS techniques for assessing hypoxia in breast cancer, along with their evolving clinical applications. The integration of these techniques in clinical practice holds promising implications for breast cancer management.Evidence Level5Technical EfficacyStage 1

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Whole-tumor histogram analysis of diffusion-weighted imaging and dynamic contrast-enhanced MRI for soft tissue sarcoma: correlation with HIF-1alpha expression

Xie

et al. 2022

Eur Radiol

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Correlations between DWI, IVIM, and HIF‐1α expression based on MRI and pathology in a murine model of rhabdomyosarcoma

Cited by 5 publications

References 34 publications

Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside

Contemporary preclinical mouse models for pediatric rhabdomyosarcoma: from bedside to bench to bedside

Assessment of Hypoxia in Breast Cancer: Emerging Functional MR Imaging and Spectroscopy Techniques and Clinical Applications

Whole-tumor histogram analysis of diffusion-weighted imaging and dynamic contrast-enhanced MRI for soft tissue sarcoma: correlation with HIF-1alpha expression

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