Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth

Washino, Noriaki; Saijo, Yasuaki; Sasaki, Seiko; Kato, Shinichi; S, Ban; Konishi, Kooichi; Ito, Rie; Nakata, Ayako; Iwasaki, Yusuke; Saito, Koichi; Nakazawa, Hiroyuki; Kishi, Reiko

doi:10.1289/ehp.11681

Cited by 261 publications

(191 citation statements)

References 46 publications

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“…In 2002, the Hokkaido University Graduate School of Medicine established a hospital-based prospective cohort study entitled the "Hokkaido Study on Environment and Children's Health" to investigate the possible adverse effects of PCBs, PCDDs/PCDFs, perfluorinated chemicals, and many other environmental contaminants on fetal growth and neurodevelopment Sasaki et al, 2008;Nakajima et al, 2006;Washino et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes.However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% CI: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

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Section: Methodsmentioning

confidence: 99%

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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“…8 Inoue et al 18 were the first to report the presence of PFCs in human maternal and cord blood samples, and several other studies followed. [19][20][21] Furthermore, recent epidemiological studies in Denmark, USA and Japan [21][22][23] have investigated possible adverse effects of PFCs on the foetus. In the Danish cohort they found an inverse association between maternal PFOA concentration and birth weight.…”

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confidence: 99%

Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study

et al. 2010

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There is limited information about both environmental and human perfluorinated compounds (PFCs) concentrations in the southern hemisphere, and for the first time, concentrations of these compounds are reported in maternal serum and cord blood of South African women. The majority of the participants were of African Black ethnicity, with a similar socioeconomic status. In maternal serum perfluorooctane sulfonate (PFOS) was found to be the most abundant PFC (1.6 ng mL ) and perfluorohexane sulfonate (PFHxS: 0.5 ng mL À1 ); however, in cord blood PFOA was the most abundant compound (1.3 ng mL À1) followed by PFOS (0.7 ng mL À1) and PFHxS (0.3 ng mL À1). Linear PFOS constituted 58% of the sum of PFOS, comparable with a reported percentage from Australia. Differences in PFC concentrations between communities were found, with the highest concentrations in urban and semi-urban areas. The median maternal PFOS concentration was lower than has been reported in other studies, whereas the PFOA concentration was the same. This clearly indicates that the exposure pathway is different from the western world. Significant differences in housing quality were observed and the urban and sub-urban community had the highest living and housing standards. Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products.

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“…Scholars have previously shown that environmental chemicals have been detected in virtually all pregnant women in the USA (e.g., Woodruff et al 2011b) with animal and human evidence suggesting links between chemical exposures and reductions in fetal growth (Fei et al 2008;Washino et al 2009;Kodavanti et al 2010;Harley et al 2011). In vivo and in vitro animal studies, for example, show adverse developmental and reproductive effects from chemicals such as brominated flame retardants found in consumer products (Schecter et al 2005).…”

Section: Chemical Presence In Bodiesmentioning

confidence: 99%

Scientific contestations over “toxic trespass”: health and regulatory implications of chemical biomonitoring

Shamasunder

Morello‐Frosch

2015

J Environ Stud Sci

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Biomonitoring has chronicled hundreds of synthetic chemicals in human bodies. With the proliferation of biomonitoring studies from diverse stakeholders comes the need to better understand the public health consequences of synthetic chemical exposures. Fundamental disagreements among scientific experts as to the nature and purpose of biomonitoring data guide our investigation in this paper. We examine interpretations of biomonitoring evidence through interviews with 42 expert scientists from industry, environmental health and justice movement organizations (EHJM), academia, and regulatory agencies and through participant observation in scientific meetings where biomonitoring evidence is under debate. Both social movements and industry stakeholders frame the meaning of scientific data in ways that advance their own interests. EHJM scientists argue that biomonitoring data demonstrates involuntary Btoxic trespass^and underscores a policy failure that allows for the pervasive use of untested chemicals. Industry scientists seek to subsume biomonitoring data under existing regulatory risk assessment paradigms. Our analysis reveals one area of convergence (validity of Centers for Disease Control surveillance data) and seven areas of contestation regarding the scientific, public health, and policy implications of biomonitoring evidence, among regulatory, industry, and EHJM scientists including: chemical presence in bodies, biological mechanisms of health impact, use of biomonitoring equivalents, limits of targeted biomonitoring, limits of detection, policy influence of advocacy biomonitoring, and relevance of biomonitoring to motivate policy change. These areas of scientific contestation provide insight into the persistent challenges of regulating chemicals even in the midst of mounting evidence of widespread exposure to multiple compounds with implications for human health.

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Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal Growth

Cited by 261 publications

References 46 publications

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study

Scientific contestations over “toxic trespass”: health and regulatory implications of chemical biomonitoring

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