Correlations between polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A and C-C motif chemokine receptor 5 genes and infection with the hepatitis B virus in three ethnic groups in China

Abstract

ObjectiveTo determine whether genetic polymorphisms in the uridine diphosphate-glucuronosyltransferase 1A (UGT1A) and the C-C motif chemokine receptor 5 (CCR5) genes are associated with hepatitis B virus (HBV) infection in Yi, Yao and Han ethnic groups in the Guizhou Province of China.MethodsThe study enrolled subjects with and without HBV infection. Whole blood was used for DNA genotyping using standard techniques. The study determined the frequencies of several polymorphic alleles (UGT1A6 [rs2070959], UGT1A1 [rs8175347], CCR5-59029 [rs1799987] and CCR5Δ32 [rs333]) and then characterized their relationship with HBV infection.ResultsA total of 404 subjects were enrolled in the study: 138 from the Yao group, 101 from the Yi group and 165 from the Han group. There was a significant difference in the frequency of UGT1A1 rs8175347 polymorphisms among the three groups. The rates of 7TA carriers of UGT1A1 rs8175347 in all three groups were significantly higher than the other genotypes. Individuals with genotype AA of UGT1A6 rs2070959 in the Yi group had a higher risk for HBV infection than in the Yao and Han groups. The frequency of genotype GG in CCR5-59029 in the Yao group was significantly higher than in the Yi group. The genotypes of CCR5Δ32 were not associated with HBV infection.ConclusionThese findings provide genetic and epidemiological evidence for an association of UGT1A and CCR5-59029 polymorphisms with HBV infection in Chinese Yi and Yao populations.

Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases

“…Several studies investigated the role of the CCR5Δ32 polymorphism in HBV infection. Some of them found no association between those variables (Arababadi et al, 2010;Khorramdelazad et al, 2013;Safari et al, 2017;Zhang et al, 2018;Moudi et al, 2019). In other studies, the absence of CCR5Δ32 allele in the sample, due to ethnic features of the evaluated population, precluded the analysis concerning the potential impact of this genetic variant on HBV infection (Ahn et al, 2006;Li et al, 2011).…”

Association of Genetic Polymorphisms with Complications of Implanted LVAD Devices in Patients with Congestive Heart Failure: A Kazakhstani Study

“…Genetic polymorphism in UGT1A6 can influence to the expression of different metabolic activities of the enzyme [ 24 , 43 , 44 ]. UGT1A6 gene polymorphism rs2070959 was found to be associated with colon and colorectal cancer [ 24 , 45 , 46 , 47 ]. Furthermore, UGT1A6 gene polymorphism rs2070959 was found not to be associated in cardiovascular patients with gastrointestinal complaints in aspirin treatment [ 42 ].…”

“…Patients with GG genotype require a higher aspirin dose due to the enzyme’s higher metabolic activity [ 44 ]. However, there were controversial findings regarding this SNP, showing that GG genotype polymorphism rs2070959 in UGT1A6 gene is associated with decreased enzyme activity [ 46 , 48 ].…”