Correlations Between Leptin Gene Polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and Anthropometrical and Biochemical Parameters in Children With Obesity

Mărginean, Cristina Oana; Voidăzan, Septimiu; Meliţ, Lorena Elena; Crauciuc, Andrei; Duicu, Carmen; Bănescu, Claudia

doi:10.1097/md.0000000000003115

Cited by 35 publications

(36 citation statements)

References 51 publications

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“…In a previous study of our team we did not find any correlation between the G allele and gender nor age. [35] Similar results reported by Pyrzak et al [60] highlighted the association between LEPR rs1137101 gene polymorphism and obesity. Even though the data are contradictory, in selected cases it is better to assess the LEPR gene polymorphism and leptin serum levels, taking under consideration the amount of obesity-related complications and their systemic impact.…”

Section: Discussionsupporting

confidence: 70%

“…Recent studies sustain that LEPR rs1137101 (Gln223Arg) is the most frequent one associated with obesity. [33–35] Therefore, in some particular cases, it is important to assess these genetic factors, for example in obese pregnant women, those with excessive GWG, or even those who previously had newborns with high birth weight. In the everyday medical practice both FTO and LEPR polymorphisms can be important diagnostic tools, and even prevention ones if they are assessed in pregnant women at risk for having a macrosomic newborn, or a child with increased susceptibility for developing obesity later in life.…”

Section: Introductionmentioning

confidence: 99%

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The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

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The aim of this study was to assess the impact of mothers’ and newborns’ fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother–newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029). There was a significant interaction effect between newborn and mother LEPR rs1137101 polymorphism on birth weight (P = 0.009) and BMI (P = 0.007). We noticed significantly increased birth weight and BMI in newborns carriers of AG + GG genotype, coming from mothers with AA genotype (P = 0.006). There was no evidence of significant interaction effect between newborn and mother FTO rs9939609 polymorphism on the studied anthropometrical data (P > 0.05). In addition, lower BMI scores (P = 0.042) were observed in newborns carriers of TT genotype whose mothers had AA + AT genotype. Lower MUAC scores (P = 0.041) were noticed in newborns carriers of AA + AT genotype whose mothers had AA + AT genotype for FTO rs9939609 gene polymorphism. Newborns carriers of the AG + GG genotype (P = 0.003) of LEPR rs1137101 coming from mothers with increased FMI (upper tertile) had significantly increased BMIs.Presence of the variant A allele of FTO rs9939609 polymorphism in mothers decreased BMI and MUAC in newborns. The impact of LEPR rs1137101 polymorphism on BMI and birth weight in newborns differed depending on the presence/absence of the dominant LEPR allele in mothers. In addition, we noticed that maternal FMI presented a significant positive effect on newborns’ BMI by changing the effect of LEPR rs1137101.We can conclude that mothers’ FTO rs9939609 and LEPR rs1137101 gene polymorphisms presented an impact on birth weight and newborns’ BMI, therefore being involved in the newborns’ nutritional status and in the design of a potential protocol.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

et al. 2016

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“…Sook‐Ha and Yee‐How showed significant association of 109 K/R and several biochemical and anthropometric parameters (waist circumference, BMI, visceral fat level, subcutaneous fat, total body fat and Leptin level) and the value of Leptin level is higher with K alleles (32.34 ± 42.21 ng/mL) vs (26.70 ± 31.96 ng/mL) for R alleles . Controversy, Marginean et al found a significant association with hip and abdominal circumference among the anthropometric parameters and with the serum level of interleukin 6 and tumour necrosis factor alpha (TNF‐α) but not with serum level of Leptin. For the K109R polymorphism, some studies such as Mizuta et al and Rosmond et al showed a significant association with obesity .…”

Section: Discussionmentioning

confidence: 99%

“…LEPR Gln223Arg (223Q/R) polymorphism was associated with lower Leptin levels in postmenopausal Caucasian women . Recently, Marginean et al showed that the Leptin values associated with the LEPR 223 QQ genotype were higher in obese children vs controls.…”

Section: Discussionmentioning

confidence: 99%

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Zayani

Hamdouni

Boumaiza

et al. 2018

Int J Experimental Path

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Adipose tissue is an important endocrine organ that secretes a number of adipokines, like Leptin (LEP). The aim this study was to investigate the prevalence of single nucleotide polymorphisms in LEP gene (LEP 3'UTR A/C, -2548 G/A) and LEPR (K109R and Q223R) and their association with Leptin level and obesity. We recruited 169 non-obese (body mass index [BMI] = 24.51-3.69 kg/m ) and 160 obese (BMI = 36-4.78 kg/m ) patients. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism, BMI was calculated, and Leptin level was measured by ELISA. Statistical analyses were performed by spss19.0. According to LEP 3'UTR A/C polymorphism, AC and CC genotype carriers had higher Leptin levels than AA genotype carriers, respectively, 31[0.05-148.8] (P = .008) vs 41[0.05-111.6] (P = .003). The K109R polymorphism was associated with obesity (P = .025) and seems to significantly decrease the LEP levels (P < .001). Concerning LEP G2548A polymorphism, our results showed that the OR of obesity associated with 2548 AA/GG was 1.87[1.106-2.78] P = .028 vs 1.41[1.035-1.85] P = .045 for 223AA/GG polymorphism. In our haplotype analysis, one haplotype seems to be the more protective and one other seems to be the highest risk to obesity. LEP 3'UTR A/C and LEPR K109R polymorphisms were associated with Leptin level and obesity.

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“…Lys 109 Arg (K109R) (rs1137100) Polymorphism of lepR gene in exon 4 by displacement of adenine with guanine in codon 109, and case displacement of lysine amino acid with arginine in extracellular part of receptor might be a reason for leptin ability to bind to the receptor (14).…”

Section: Introductionmentioning

confidence: 99%

Association of Leptin Receptor Gene Gln223Arg and lys109Arg Polymorphisms with Obesity and Overweight in an Iranian Young Population

2017

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Background: Obesity is an energy imbalance disorder that happens due to deficiency of energy intake and consumption. Leptin is an important hormone that regulates energy expenditure. Leptin through its receptors located in the hypothalamus regulates appetite and energy consumption. Objectives: In this study we tried to determine the association of leptin receptor (LEPR) gene polymorphisms (rs1137101), Lys223Arg and Gln109Arg (rs1137100), with overweight and obesity. Methods: We examined the two polymorphisms in 240 subjects consisting of obese, overweight, low-weight, and normal weight (as control) subjects among students of Zanjan Islamic Azad University. For Genotyping, we used PCR-RFLP. Statistical analysis was performed using t-test and chi-square test to show any significant difference between the groups. Results: There was no significant difference in allelic and genotypic frequency of Gln109Arg polymorphism (by A > G substitution) between our study groups. In Lys223Arg polymorphism by A > G substitution, the frequency of AG genotype was higher in the normal group, and the frequency of AA genotype was higher in the obese and overweight groups; but, there was no significant difference in GG genotype and allelic frequency (P < 0.05). Conclusions: In our population, Lys223Arg polymorphism of LEPR gene was associated with obesity; Gln 223 of leptin receptor gene was located in the extra cellular part of receptor and substitution of Glu by Arg in this position might affect leptin signaling. Lys/Arg heterozygote might have protective effects.

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Correlations Between Leptin Gene Polymorphisms 223 A/G, 1019 G/A, 492 G/C, 976 C/A, and Anthropometrical and Biochemical Parameters in Children With Obesity

Cited by 35 publications

References 51 publications

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

The FTO rs9939609 and LEPR rs1137101 mothers–newborns gene polymorphisms and maternal fat mass index effects on anthropometric characteristics in newborns

Leptin and Leptin receptor polymorphisms, plasma Leptin levels and obesity in Tunisian volunteers

Association of Leptin Receptor Gene Gln223Arg and lys109Arg Polymorphisms with Obesity and Overweight in an Iranian Young Population

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