Correlations between iron content in knee joint tissues and chosen indices of peripheral blood morphology

Brodziak-Dopierała, Barbara; Roczniak, Wojciech; Jakóbik‐Kolon, Agata; Kluczka, Joanna; Koczy, Bogdan; Kwapuliński, Jerzy; Babuśka–Roczniak, Magdalena

doi:10.17219/acem/64823

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…The reasons for our sampling choices are as follows: (I) the femoral greater trochanter and the proximal part of the tibia have similar biomechanical characteristics and both are nonstress concentration areas (12)(13)(14)(15). According to Wolff's laws, the structure of the skeleton changes with the stress load it receives; thus, the two parts should have similar bone structures; (II) previous reports have shown that there is no significant difference in the concentrations of trace elements, including Cd, Cr, Zn, Fe, Ca, and many other metal elements, between the femur and the tibia in humans, chickens, and rabbits (16)(17)(18)(19). Therefore, we believe that the cancellous bone samples we obtained from the femur and the tibia have consistent structures and can be used for side-by-side comparisons.…”

Section: Table 5 Pearson's Correlation Analysis Between Osteopenia Anmentioning

confidence: 99%

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Chang¹,

Shen²,

Zhang³

et al. 2018

Ann. Transl. Med.

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Background: Excessive amounts of heavy metals such as cadmium, chromium, cobalt, lead, thallium, and manganese are extremely harmful to the human body. These elements can accumulate in bone and impact bone metabolism. In this study, we investigated the relationship between age and the concentrations of these elements in human bone and blood. Methods: Bone and blood samples were obtained from both older and younger patients. The concentrations of the elements under investigation were measured by inductively coupled plasma mass spectrometry (ICP-MS), and the specific concentrations in the bone and blood were then calculated. Results: The results showed that with increasing age, the concentrations of chromium, cobalt, and thallium in bone decreased significantly, while the concentration of cadmium in bone markedly increased. However, there was no clear correlation between age and the concentrations of these heavy metals in blood. Notably, there was a close correlation between the concentration of cobalt in bone and the presence of osteopenia. Conclusions: Senescence of the human body is accompanied by the shifting of cobalt, chromium, and thallium from the bone to the outer-bone. However, the concentration of cadmium in bone increases with age. These changes are very likely to be related to the equilibrium of bone metabolism in senescent individuals. In addition, only cobalt was shown to be significantly related to osteopenia.

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Section: Table 5 Pearson's Correlation Analysis Between Osteopenia Anmentioning

confidence: 99%

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Chang¹,

Shen²,

Zhang³

et al. 2018

Ann. Transl. Med.

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“…Budis et al [48] found similar Fe concentrations in the cartilage and spongy bone in men and women. Brodziak-Dopierała et al [49] also noted no statistically significant differences in Fe concentration in the meniscus between men and women. Some researchers have observed differences in Fe concentration between older and younger patients; however, those differences are usually slight [46,50,51].…”

Section: Discussionmentioning

confidence: 91%

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

Kot

Kosik-Bogacka

Ziętek

et al. 2020

IJERPH

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The aim of this study was to determine the concentrations of iron, nickel, molybdenum, and vanadium in the knee joint. We also examined the relationships between the concentrations of these metals in the knee joint and the influence of varied factors on the concentration of Fe, Ni, Mo, and V. The study of these trace elements is important, because these elements are used alone and in combination in diet supplements, and they are components of biomaterials implanted in medicine. The study materials, consisting of the spongy bone, cartilage, meniscus, anterior cruciate ligament (ACL), and infrapatellar fat pad, were obtained from 34 women and 12 men from northwestern Poland. The concentrations of Ni, Fe, Mo, and V were determined using spectrophotometric atomic absorption in inductively coupled argon plasma (ICP-AES). We found significantly higher Mo concentrations in the ACL of women than men. There was a significant difference in the Mo concentration in the spongy bone between patients from cities with fewer than 100,000 inhabitants and patients from cities with more than 100,000 residents. Iron concentrations in the spongy bone were higher in non-smoking patients and those who did not consume alcohol. Vanadium concentrations were higher in the infrapatellar fat pads in abstainers. In patients who had not undergone arthroscopy surgery, V concentration was lower in cartilage. The concentrations of V in the cartilage and infrapatellar fat pad were higher in osteoporotic patients than in non-osteoporotic patients. There were significant differences in Fe concentrations in the meniscus, with the lowest in osteoporotic patients. We noted lower Mo concentrations in the spongy bone of patients with rheumatoid arthritis. Furthermore, we noted some new interactions among metals in the studied structures of the knee joint. The results reported in this study show the influence of gender, place of residence, smoking, consumption of alcohol, arthroscopy surgery, osteoporosis, and rheumatoid arthritis on the Fe, Ni, Mo, and V concentrations in the studied structures of the knee joint.

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“…Evidence has shown temporal and spatial changes in iron homeostasis and lipid peroxidation. Brodziak-Dopierała et al [ 125 ] found significantly different levels of iron in various components of the knee joint in patients with OA. The highest iron content was found in the femoral bone portion of the knee joint followed by the meniscus, and the lowest iron content was found in the tibia portion.…”

Section: Discussionmentioning

confidence: 99%

The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation

Zhang

et al. 2022

Antioxidants

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Ferroptosis, a recently discovered regulated cell death modality, is characterised by iron-dependent accumulation of lipid hydroperoxides, which can reach lethal levels but can be specifically reversed by ferroptosis inhibitors. Osteoarthritis (OA), the most common degenerative joint disease, is characterised by a complex pathogenesis involving mechanical overload, increased inflammatory mediator levels, metabolic alterations, and cell senescence and death. Since iron accumulation and oxidative stress are the universal pathological features of OA, the role played by ferroptosis in OA has been extensively explored. Increasing evidence has shown that iron dyshomeostasis and lipid peroxidation are closely associated with OA pathogenesis. Therefore, in this review, we summarize recent evidence by focusing on ferroptotic mechanisms and the role played by ferroptosis in OA pathogenesis from the perspectives of clinical findings, animal models, and cell research. By summarizing recent research advances that characterize the relationship between ferroptosis and OA, we highlight avenues for further research and potential therapeutic targets.

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Correlations between iron content in knee joint tissues and chosen indices of peripheral blood morphology

Cited by 6 publications

References 26 publications

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Study on the relationship between age and the concentrations of heavy metal elements in human bone

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation

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