Correlations between internal and external ocular factors and macular pigment optical density

Abstract

Aim. To assess the relationship between the macular pigment optical density and blue-light issued by computers, glare sensibility, with iris color, age, sex, or refractive errors. Material and methods. 83 patients (166 eyes) were enrolled in a prospective observational study. They were divided into 2 groups: group 1 (study group) - computer using patients (time spent in front of the computer for minimum 8 hours per day, 5 days per week, 2 years) - 43 patients and group 2 (control group) - 40 patients. The following investigations were conducted in all the selected cases: visual acuity, refraction, biomicroscopy, measurement of the MPOD, glare sensitivity, assessment of eye color.Results. 51.81% of the patients were included in group 1, while the rest, 48.19%, were in group 2. Thus, the MPOD had a mean value of (+/ -SD) 0.42+/ -0.13 (t = -1.08, p = 0.28) in group 1, and 0.44+/ -0.16 on the LE. The results showed a MPOD mean value of 0.51+/ - 0.16 in group 2 and 0.51+/ -0 .16. (t = 0.49, p = 0 .62) on the LE. 55.77% of the patients with light colored iris and 56.14% of those with dark iris had a low MPOD.Conclusions. The data from our study failed to illustrate a significant correlation between MPOD and blue-light issued by computers. Furthermore, a statistic significant relationship regarding iris color, refractive errors, glare, and MPOD was not observed.Abbreviations: L = lutein, Z = zeaxanthin, MZ = meso-zeaxanthin, AMD = age related macular degeneration, MPOD = macular pigment optical density, MP = macular pigment, HFP = Heterochromatic Flicker Photometry, RE = right eye, LE = left eye

Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina

“…The mean MPOD in the current study was 0.59. This value was comparable to those measured using the HFP technique for young to middle-aged healthy individuals in our previous studies (0.67 [17] and 0.65 [16]) and other studies using other techniques (0.47 to 0.72 [35][36][37]).…”

Effects of lutein supplementation in age-related macular degeneration

“…Some studies did record BMI, because BMI would affect the concentration of lutein in serum [58], which was found not to differ significantly between patients who received supplementation or not. One study suggested that iris color affects MPOD, but another showed no such relationship [59]. Iris color was not recorded in studies included in this meta-analysis and therefore could not be analyzed.…”

The association between macular pigment optical density and visual function outcomes: a systematic review and meta-analysis

“…Twenty-two publications met the inclusion criteria (Table 1, Fig. 1, Supplementary Table 2) [11,12,14,16,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Fifteen studies were conducted in the USA, three in Ireland, one in England, one in Spain, one in Romania, and one did not clearly specify the country.…”