Correlations between Hormones, Physical, and Affective Parameters in Aging Urologic Outpatients

Beutel, Manfred E.; Wiltink, Joerg; Hauck, Ekkehard W.; Auch, D.; Behre, Hermann M.; Brähler, Elmar; Weidner, W.

doi:10.1016/j.eururo.2005.02.015

Cited by 65 publications

(46 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data suggest (albeit indirectly) that deficiencies of sex hormones could underlie a decrease in sexual function in both men and women. Second, some basal hormone studies have observed correlations between blood levels of sex steroids and sexual functioning, while other studies have observed lower sex hormone levels in subjects with decreased sexual function compared with asymptomatic control groups (Schiavi et al, 1991;Cawood and Bancroft, 1996;Santoro et al, 2005;Basar et al, 2005;Modelska et al, 2004;Travison et al, 2006;Beutel et al, 2005;Kennedy et al, 1997;Nyunt et al, 2005;Dennerstein et al, 1994Dennerstein et al, , 2002Slob et al, 1996;Adams et al, 1978;Bancroft et al, 1980;Meuwissen and Over, 1992;Doering et al, 1974). Finally, several longitudinal studies have demonstrated the reduction of sexual function under the following circumstances: after medical or surgical castration; after the development of hypogonadism secondary to a variety of medical illnesses; after the administration of medications that inhibit sex hormone production (Marberger et al, 2006); and during age-related reproductive senescence (Dennerstein et al, 2002;Koster and Garde, 1993).…”

Section: Introductionmentioning

confidence: 99%

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Schmidt

Steinberg

Negro

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

Studies fail to find uniform effects of age-related or induced hypogonadism on human sexual function. We examined the effects of induced hypogonadism on sexual function in healthy men and women and attempted to identify predictors of the sexual response to induced hypogonadism or hormone addback. The study design used was a double-blind, controlled, crossover (self-as-own control). The study setting was an ambulatory care clinic in a research hospital, and the participants were 20 men (average ± SD age ¼ 28.5 ± 6.2 years) and 20 women (average ± SD age ¼ 33.5 ± 8.7 years), all healthy and with no history of psychiatric illness. A multidimensional scale assessing several domains of sexual function was the main outcome measure. Participants of the study received depot leuprolide acetate (Lupron) every 4 weeks for 3 months (men) or 5 months (women). After the first month of Lupron alone, men received (in addition to Lupron) testosterone enanthate (200 mg intramuscularly) or placebo every 2 weeks for 1 month each. Women received Lupron alone for 2 months, and then, in addition to Lupron, they received estradiol and progesterone for 5 weeks each. The results of the study: in women, hypogonadism resulted in a significant decrease in global measures of sexual functioning, principally reflecting a significant decrease in the reported quality of orgasm. In men, hypogonadism resulted in significant reductions in all measured domains of sexual function. Testosterone restored sexual functioning scores in men to those seen at baseline, whereas neither estradiol nor progesterone significantly improved the reduced sexual functioning associated with hypogonadism in women. Induced hypogonadism decreased sexual function in a similar number of men and women. No predictors of response were identified except for levels of sexual function at baseline. In conclusion, our data do not support a simple deficiency model for the role of gonadal steroids in human sexual function; moreover, while variable, the role of testosterone in sexual function in men is more apparent than that of estradiol or progesterone in women.

show abstract

Section: Introductionmentioning

confidence: 99%

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Schmidt

Steinberg

Negro

et al. 2008

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…75 However, loss of libido can be reported by men with total testosterone levels in the normal range. 76 Erectile dysfunction signifies the lack of ability to achieve and sustain penile erection sufficient for satisfactory intercourse and its prevalence increases markedly with age.…”

Section: Testosterone and Sexual Health In Aging Menmentioning

confidence: 99%

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

View full text Add to dashboard Cite

As men grow older, testosterone levels fall, with a steeper decline in unbound or free testosterone compared with total testosterone concentrations. Lower testosterone levels have been associated with poorer cognitive function, and with impaired general and sexual health in aging men. Recently, lower testosterone levels have been linked with metabolic syndrome and type II diabetes, both conditions associated with cardiovascular disease, and shown to predict higher overall and cardiovascular-related mortality in middle-aged and older men. However, reverse causation has to be considered, as systemic illness may result in reduced testosterone levels. Thus, the strength of these associations and the likely direction of causation need to be carefully considered. Furthermore, these conditions may overlap, for example aging, lower testosterone levels, erectile dysfunction and cardiovascular disease are interrelated. Cross-sectional and longitudinal observational studies may be informative. However, ultimately randomized controlled trials of testosterone therapy are needed to clarify its role in the maintenance of general and sexual health in aging men. Testosterone therapy should be considered in hypogonadal men who meet rigorous criteria for the diagnosis of androgen deficiency. Additional consideration should be given to designing and testing interventions that may prevent or ameliorate the age-related decline in testosterone levels in men.

show abstract

“…28 are not recommended for the diagnosis of hypogonadism because of low specificity (level 3, grade B). 24,29,30 Recommendation 3: laboratory diagnosis 3.1. In patients at risk or who are suspected of hypogonadism, a thorough physical and biochemical work-up is necessary (level 4, grade A).…”

Section: Process For Development Of Recommendationsmentioning

confidence: 99%

ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males

et al. 2008

View full text Add to dashboard Cite

show abstract

Correlations between Hormones, Physical, and Affective Parameters in Aging Urologic Outpatients

Cited by 65 publications

References 34 publications

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Pharmacologically Induced Hypogonadism and Sexual Function in Healthy Young Women and Men

Are declining testosterone levels a major risk factor for ill-health in aging men?

ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males

Contact Info

Product

Resources

About