Correlations between hemodynamic, oxygenation and tissue perfusion parameters during asphyxial cardiac arrest and resuscitation in a pediatric animal model

López‐Herce, Jesús; Fernández, Bárbara; Urbano, Javier; Mencía, Santiago; Solana, María José; Castillo, Jimena del; Rodrı́guez-Núñez, Antonio; Bellón, José María; Carrillo, Ángel

doi:10.1016/j.resuscitation.2011.02.013

Cited by 14 publications

(13 citation statements)

References 27 publications

(36 reference statements)

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“…Few authors have investigated the relationship between cardiac output and regional spectroscopy data. A study based on an experimental model of swine asphyxia [17] using femoral TPTD found a weak correlation of the CI with both rSO 2 c (r = 0.26) and rSO 2 r (r = 0.23). On the other hand, Butha et al [4] reported a better correlation between the CI obtained using pulmonary artery catheterization and rSO 2 c (r = 0.45) in 29 stable patients after heart transplantation.…”

Section: Discussionmentioning

confidence: 99%

Combined Cerebral and Renal Near-Infrared Spectroscopy After Congenital Heart Surgery

et al. 2015

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The maintenance of an adequate oxygen supply to tissues after congenital heart surgery is essential for good outcomes. The objective of this study was to assess the usefulness of near-infrared spectroscopy (NIRS) for estimating central venous oxygen saturation (ScvO2) using both cerebral and renal measurements, explore its relation with cardiac output measurements and check its ability to detect low cardiac output. A prospective observational pilot study was conducted in patients weighing <10 kg undergoing cardiopulmonary bypass surgery. Spectroscopy probes were placed on the forehead and renal area, and serial cardiac output measurements were obtained by femoral transpulmonary thermodilution over the first 24 h after surgery. In the 15 patients studied, ScvO2 was correlated with cerebral (r = 0.58), renal (r = 0.60) and combined (r = 0.71) measurements. Likewise, the systolic index was correlated with the NIRS signals: cerebral (r = 0.60), renal (r = 0.50) and combined (r = 0.66). Statistically significant differences were found in the NIRS measures registered in the 29 low cardiac output events detected by thermodilution: cerebral: 62 % (59-65) versus 69 % (63-76); renal: 83 % (70-89) versus 89 % (83-95); and combined 64 % (60-69) versus 72 % (67-76). In our series, combined cerebral and renal monitoring was correlated with central venous oxygen saturation and cardiac output; low cardiac output detection associated a different spectroscopy pattern.

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Section: Discussionmentioning

confidence: 99%

Combined Cerebral and Renal Near-Infrared Spectroscopy After Congenital Heart Surgery

et al. 2015

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“…There are no studies examining the correlation between global hemodynamic and tissue perfusion parameters during cardiac arrest and resuscitation (30,31). A study showed that global hemodynamic parameters do not correlate with oxygenation and tissue perfusion values (18); there may be cardiac dysfunction after ROSC with coronary blood flow not reducing the condition. Thus, it is necessary to monitor the microcirculatory blood flow of the myocardium to evaluate treatment effectiveness.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is necessary to monitor the microcirculatory blood flow of the myocardium to evaluate treatment effectiveness. The new PET tracer, 18 F-flurpiridaz, with high myocardial extraction, allows quantitative MBF estimation from dynamic PET data and tracer kinetic modeling (32). MPI is a simple and noninvasive method for detecting myocardial ischemia, monitoring MBF after ROSC.…”

Section: Discussionmentioning

confidence: 99%

“…All animals had been fasted for at least 8 h before starting PET/computed tomography (CT) examination and remained under anesthesia throughout the entire experiment. 18 F-flurpiridaz was administered by hand as a bolus injection into the femoral vein and flushed with 5-mL saline solution (injection time of 5 s). The protocol was repeated at baseline (before cardiac arrest), and 4 h after ROSC.…”

Section: F-flurpiridaz Pet Mpimentioning

confidence: 99%

“…In addition to PCCO calibration, transpulmonary thermodilution also yields cardiac preload by means of global end-diastolic volume (GEDV) and estimation of both intrathoracic blood volume (ITBV) and EVLW. Furthermore, the PiCCO2 continuously measures ScvO 2 after calibration with blood gas analysis results and can continuously calculate oxygen delivery (DO 2 ) and VO 2 (17)(18)(19). Therefore, in addition to monitoring hemodynamics, PiCCO2 can also reflect tissue perfusion and is an ideal monitoring tool after ROSC.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced external counterpulsation improves cardiac function in Beagles after cardiopulmonary resuscitation

Xiong

Zhang

et al. 2020

Braz J Med Biol Res

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The aim of this study was to investigate the influence of enhanced external counterpulsation (EECP) on the cardiac function of beagle dogs after prolonged ventricular fibrillation. Twenty-four adult male beagles were randomly divided into control and EECP groups. Ventricular fibrillation was induced in the animals for 12 min, followed by 2 min of cardiopulmonary resuscitation. They then received EECP therapy for 4 h (EECP group) or not (control group). The hemodynamics was monitored using the PiCCO2 system. Blood gas and hemorheology were assessed at baseline and at 1, 2, and 4 h after return of spontaneous circulation (ROSC). The myocardial blood flow (MBF) was quantified by 18 F-flurpiridaz PET myocardial perfusion imaging at baseline and 4 h after ROSC. Survival time of the animals was recorded within 24 h. Ventricular fibrillation was successfully induced in all animals, and they achieved ROSC after cardiopulmonary resuscitation. Survival time of the control group was shorter than that of the EECP group [median of 8 h (min 8 h, max 21 h) vs median of 24 h (min 16 h, max 24 h) (Kaplan Meyer plot analysis, P=0.0152). EECP improved blood gas analysis findings and increased the coronary perfusion pressure and MBF value. EECP also improved the cardiac function of Beagles after ROSC in multiple aspects, significantly increased blood flow velocity, and decreased plasma viscosity, erythrocyte aggregation index, and hematocrit levels. EECP improved the hemodynamics of beagle dogs and increased MBF, subsequently improving cardiac function and ultimately improving the survival time of animals after ROSC.

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Central Nervous System Near-Infrared Spectroscopic Monitoring: Technique and Clinical Application

Beltran

Vazquez-Colon

Baines

et al. 2022

Koht, Sloan, Toleikis's Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals

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Correlations between hemodynamic, oxygenation and tissue perfusion parameters during asphyxial cardiac arrest and resuscitation in a pediatric animal model

Cited by 14 publications

References 27 publications

Combined Cerebral and Renal Near-Infrared Spectroscopy After Congenital Heart Surgery

Combined Cerebral and Renal Near-Infrared Spectroscopy After Congenital Heart Surgery

Enhanced external counterpulsation improves cardiac function in Beagles after cardiopulmonary resuscitation

Central Nervous System Near-Infrared Spectroscopic Monitoring: Technique and Clinical Application

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