Correlations Between EEG Spectral Power and Cerebral Perfusion in Adults Undergoing Extracorporeal Membrane Oxygenation

Khan, Imad; Dar, Irfaan A.; Johnson, Thomas W.; Loose, Emily; Xu, Yama Y.; Santiago, Esmeralda; Donohue, Kelly L.; Marinescu, Mark; Gošev, Igor; Schifitto, Giovanni; Choe, Regine; Selioutski, Olga

doi:10.1101/2022.06.07.22276122

Cited by 1 publication

(3 citation statements)

References 57 publications

(70 reference statements)

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“…Combining quantitative EEG with development of algorithms to provide reliable automated live interpretations of acute changes in EEG tracings and DCS may be a novel prognostic tool for detecting brain injury in ECMO patients. 95 Properties and limitations of neuromonitoring modalities have been described in Table 2. 96…”

Section: Continuous Neuromonitoring Devicesmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

“…These tools may readily be integrated with EEG including quantitative EEG with automated detection, to improve the capability for dynamic assessment of the neurovascular unit and for real-time detection of critical neurologic events as this will provide opportunities for interventions to prevent permanent neurologic injury. 95,99 Additional research is needed to study the development and integration of continuous neurologic monitoring methods with the goal of assisting clinicians in stratifying patients into risk categories for brain injury, determining response to neuroprotective interventions, and providing accurate prognostication of long-term outcomes. 96…”

Section: Future Directionsmentioning

confidence: 99%

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Neuromonitoring of Pediatric and Adult Extracorporeal Membrane Oxygenation Patients: The Importance of Continuous Bedside Tools in Driving Neuroprotective Clinical Care

Tabet,

Custer,

Khan

et al. 2023

ASAIO Journal

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Extracorporeal membrane oxygenation (ECMO) is a form of temporary cardiopulmonary bypass for patients with acute respiratory or cardiac failure refractory to conventional therapy. Its usage has become increasingly widespread and while reported survival after ECMO has increased in the past 25 years, the incidence of neurological injury has not declined, leading to the pressing question of how to improve time-to-detection and diagnosis of neurological injury. The neurological status of patients on ECMO is clinically difficult to evaluate due to multiple factors including illness, sedation, and pharmacological paralysis. Thus, increasing attention has been focused on developing tools and techniques to measure and monitor the brain of ECMO patients to identify dynamic risk factors and monitor patients’ neurophysiological state as a function in time. Such tools may guide neuroprotective interventions and thus prevent or mitigate brain injury. Current means to continuously monitor and prevent neurological injury in ECMO patients are rather limited; most techniques provide indirect or postinsult recognition of irreversible brain injury. This review will explore the indications, advantages, and disadvantages of standard-of-care, emerging, and investigational technologies for neurological monitoring on ECMO, focusing on bedside techniques that provide continuous assessment of neurological health.

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Section: Continuous Neuromonitoring Devicesmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%