Correlations between cutaneous malignant melanoma and other cancers: An ecological study in forty European countries

Abstract

Background:The presence of noncutaneous neoplasms does not seem to increase the risk of cutaneous malignant melanoma; however, it seems to be associated with the development of other hematological, brain, breast, uterine, and prostatic neoplasms. An ecological transversal study was conducted to study the geographic association between cutaneous malignant melanoma and 24 localizations of cancer in forty European countries.Methods:Cancer incidence rates were extracted from GLOBOCAN database of the International Agency for Research on Cancer. We analyzed the age-adjusted and gender-stratified incidence rates for different localizations of cancer in forty European countries and calculated their correlation using Pearson's correlation test.Results:In males, significant correlations were found between cutaneous malignant melanoma with testicular cancer (r = 0.83 [95% confidence interval (CI): 0.68–0.89]), myeloma (r = 0.68 [95% CI: 0.46–0.81]), prostatic carcinoma (r = 0.66 [95% CI: 0.43–0.80]), and non-Hodgkin lymphoma (NHL) (r = 0.63 [95% CI: 0.39–0.78]). In females, significant correlations were found between cutaneous malignant melanoma with breast cancer (r = 0.80 [95% CI: 0.64–0.88]), colorectal cancer (r = 0.72 [95% CI: 0.52–0.83]), and NHL (r = 0.71 [95% CI: 0.50–0.83]).Conclusions:These correlations call to conduct new studies about the epidemiology of cancer in general and cutaneous malignant melanoma risk factors in particular.

Family history of cancer in children and adolescents with germ cell tumours: a report from the Children’s Oncology Group

“…The lack of previous associations for prostate cancer and lymphatic/haematologic malignancy suggests that these findings should be considered hypothesis-generating and provide future avenues for research. In contrast, previous studies have provided some evidence for a relationship with family history of melanoma and adult testicular cancer (Hemminki and Chen, 2006; Larson et al , 2007; Serrano et al , 2016). In support of our previous findings suggesting an elevated risk of melanoma in relatives of paediatric GCT cases (Poynter et al , 2010), we observed an elevated risk of melanoma in male relatives of probands and an elevated, but non-significant risk of melanoma in female relatives of probands.…”