Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI &lt;30 and a late-onset preeclampsia

Eleuterio, Nibia Mariana; Palei, Ana C.; Machado, Jackeline de Souza Rangel; Tanus‐Santos, José Eduardo; Cavalli, Ricardo de Carvalho; Sandrim, Valéria C.

doi:10.3109/10641955.2013.837174

Cited by 13 publications

(10 citation statements)

References 46 publications

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“…The opposite conclusions have been presented by Eleuterio et al They studied patients with PE, GH, and healthy ones, and they have found no differences in leptin concentrations between groups. The groups were similar in respect of BMI, but only patients with BMI < 30 kg/m 2 were included into the study, what could explain the discrepancies between the aforementioned report and the results of our research where BMI was neither the criterion of inclusion nor exclusion [56]. These differences could also be the result of different gestational ages at the blood sampling.…”

Section: Discussionmentioning

confidence: 66%

“…The published data on this relationship is inconclusive. Song et al have found that adiponectin levels were unrelated to BMI in PE pregnant women [69], as well as Eleuterio et al who have revealed that adiponectin levels were correlated with BMI only in healthy pregnant women, but not in PE women [56]. According to the results published by Hendler et al, it seems that BMI is crucial: they have revealed that BMI ≥ 25 kg/m 2 was connected with the decrease in adiponectin levels, whereas the increase in concentrations of this adipokine characterized patients with PE of normal weight [58].…”

Section: Discussionmentioning

confidence: 99%

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Adipokines and Endothelium Dysfunction Markers in Pregnant Women with Gestational Hypertension

Poniedziałek‐Czajkowska

Mierzyński

Dłuski

et al. 2019

International Journal of Hypertension

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Objective The aim of the study was to evaluate the levels of adipokines such as adiponectin and leptin as well as soluble intercellular adhesion molecule-1 (sICAM-1) and endogenous NOS inhibitor-asymmetric dimethylarginine (ADMA), as the endothelium dysfunction markers in pregnant women with gestational hypertension (GH). Patients and Methods Adiponectin, leptin, sICAM-1, and ADMA concentrations were measured in a group of 34 patients with GH and in 32 healthy pregnant women between the 24th and 34th week of gestation with ELISA tests. Results The patients with GH compared with healthy ones were characterized by significantly higher BMI (28.09 ± 7.90 vs. 22.34 ± 4.21 kg/m2, p=0.016) and higher concentrations of leptin (45.89 ± 35.91 vs. 24.09 ± 24.40 ng/mL, p=0.006). sICAM-1 levels were also higher in the GH group but without the statistical significance (264.51 ± 50.99 vs. 232.56 ± 43.3 ng/ml, p=0.057). There were no significant differences between groups in adiponectin (8.79 ± 8.67 vs. 7.90 ± 3.71 μg/mL, p=0.46, NS) and ADMA (0.57 ± 0.26 vs. 0.60 ± 0.24 μmol/L, p=0.68, NS) levels. The significant correlation between leptin levels and BMI value was observed only in patients with GH (R = 0.56, p=0.02). Conclusions The higher levels of leptin in pregnant women with gestational hypertension may be suggestive of the role of leptin in GH development. As the patients in the GH group had higher BMI, hyperleptinemia may link obesity with gestational hypertension. The significance of leptin as the predictive marker of GH development could be implied. It could be postulated that the higher levels of sICAM-1 in the GH patients, although not statistically significant, could reflect some impairment of the endothelium function occurring in GH regardless of BMI. The comparable adiponectin levels in GH and healthy pregnant patients and the lack of its correlation with BMI may indicate the occurrence of a protective mechanism in pregnancy maintaining its concentration and preserving from the consequences of the decrease in its levels in overweight and obese patients. Since ADMA levels were similar in GH and healthy pregnant women, ADMA seems not to be involved in GH pathogenesis, suggesting that NO synthesis is not impaired in this pregnancy complication. As the data on the gestational hypertension pathogenesis and its correlations with adipokines and markers of the endothelium dysfunction are limited, further studies on this issue are warranted.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Adipokines and Endothelium Dysfunction Markers in Pregnant Women with Gestational Hypertension

Poniedziałek‐Czajkowska

Mierzyński

Dłuski

et al. 2019

International Journal of Hypertension

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“…The large majority of studies on serum leptin concentrations in women with clinical PE have found upregulated levels in the late second and third trimester [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. Compared to pregnant women with uncomplicated pregnancies, in PE leptin does not peak in week 28–32, but continues to increase markedly, only falling again after delivery [ 37 ].…”

Section: Leptin In Pre-eclampsiamentioning

confidence: 99%

“…Leptin is both associated with angiogenic molecules in PE [ 61 ] and is itself a angiogenic factor that can enhance vascular endothelial growth factor synthesis during pregnancy ( Figure 3 ) [ 96 ]. Maternal serum leptin and endothelin-1 (a highly potent vasoconstrictor that is released in conditions of hypoxia) were found to be increased in women with PE and were correlated positively with the degree of FGR in women with PE [ 97 ].…”

Section: Mechanisms For Dysregulated Leptin In Pre-eclampsia and Effects On Fetal Growthmentioning

confidence: 99%

“…Maternal serum leptin and endothelin-1 (a highly potent vasoconstrictor that is released in conditions of hypoxia) were found to be increased in women with PE and were correlated positively with the degree of FGR in women with PE [ 97 ]. The increase in leptin may be a response to under-perfusion of the placenta in an attempt to support neovascularization and improvement of nutrient delivery [ 2 , 4 , 61 , 81 ].…”

Section: Mechanisms For Dysregulated Leptin In Pre-eclampsia and Effects On Fetal Growthmentioning

confidence: 99%

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The Role of Leptin in Fetal Growth during Pre-Eclampsia

Knegt

Hedley

Kanters

et al. 2021

IJMS

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Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.

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Association between serum/plasma adiponectin levels and immune-mediated diseases: a meta-analysis

et al. 2017

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Adiponectin plays an important role in the development of immune-mediated diseases. Currently published data regarding the relationship between serum/plasma levels of adiponectin and immune-mediated diseases are inconsistent. We therefore conducted this meta-analysis to explore the association of serum/plasma adiponectin levels with immune-mediated diseases in humans. Systematic literature search was conducted to identify all relevant studies. The study quality was assessed by the Newcastle-Ottawa scale. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis. A total of 47 studies were included in our meta-analysis, including 27 studies of type 1 diabetes mellitus (T1DM), 9 studies of rheumatoid arthritis (RA), 7 studies of systemic lupus erythematosus (SLE), and 4 studies of ankylosing spondylitis (AS). The results revealed significant differences in serum/plasma levels of adiponectin between immune-mediated diseases and normal controls (SMD = 1.262, 95% CI 0.766-1.758, p < 0.001). In the subgroup analysis stratified by disease type, the serum/plasma levels of adiponectin in T1DM, RA and SLE patients were higher than those in normal control, but not in AS patients. Moreover, in the subgroup analysis stratified by gender, in both men and women group, the serum/plasma levels of adiponectin in patients with immune-mediated diseases were higher than that in the control group. Furthermore, subgroup analyses also showed that immune-mediated diseases from Asian population, Caucasian population, mean age >40 years, and BMI ≥24 kg/m had higher serum/plasma adiponectin levels when compared with normal controls. Collectively, this meta-analysis demonstrates that serum/plasma levels of adiponectin in T1DM, RA and SLE patients were higher than those in normal controls, but not in AS patients.

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Correlations between circulating levels of adipokines and anti-angiogenic factors in women with BMI <30 and a late-onset preeclampsia

Cited by 13 publications

References 46 publications

Adipokines and Endothelium Dysfunction Markers in Pregnant Women with Gestational Hypertension

Adipokines and Endothelium Dysfunction Markers in Pregnant Women with Gestational Hypertension

The Role of Leptin in Fetal Growth during Pre-Eclampsia

Association between serum/plasma adiponectin levels and immune-mediated diseases: a meta-analysis

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