Correlations Between Allergen-Specific IgE Serum Levels in Patients With Ocular Allergy

Polido, Júlia; Cabral, Thiago; Perini, Paula de Resende Campos; Fernandes, M.; Freitas, Denise de; Araújo, Maria Emília Xavier dos Santos; Serracarbassa, Pedro Durães

doi:10.1097/ico.0000000000000496

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…Hence, the matched control groups in studies evaluated in our review may not reflect a non-selected background population, but rather reflect that groups constituted by individuals selected based on history or symptoms of any allergy or allergy-associated diseases. For comparison, the prevalence of a positive allergy test in patients with seasonal allergic conjunctivitis is reported in the range of ~60%-70% (Almaliotis et al, 2013;Jongvanitpak et al, 2020;Polido et al, 2015), which is slightly higher than that we find in patients with VKC.…”

Section: Discussioncontrasting

confidence: 82%

“…The 33 studies included in our review summarized data on a total of 2122 patients with VKC. Studies were predominantly based on patients from ophthalmology clinics, and in seven studies patients were recruited from allergology clinics or paediatric clinics (Gómez‐Henao et al, 2018 ; Jongvanitpak et al, 2020 ; Kocaturk et al, 2012 ; Monzón et al, 2009 ; Polido et al, 2015 ; Tesse et al, 2010 ; Zicari et al, 2013 ). Studies were based on populations in Asia ( n = 14), Europe ( n = 14), South America ( n = 3), and Africa ( n = 2).…”

Section: Resultsmentioning

confidence: 99%

“…Kosrirukvongs et al (2001) found that the skin prick test was positive in 80% of all patients with VKC, and that house dust mites were the most prevalent allergens. Polido et al (2015) found that patients had high levels of serum total IgE and peripheral blood eosinophils, and these numbers did not differ between patients with VKC and those with the other diagnoses (atopic keratoconjunctivitis, seasonal Note: Continuous data are presented in mean ± SD unless otherwise noted. The sex distribution is presented as males:females.…”

Section: Results Of Individual Studiesmentioning

confidence: 99%

“…Patients with VKC have a significantly higher level of serum total and specific IgE when compared to healthy controls, but similar levels when compared to other allergic or atopic conditions (Baryishak et al, 1982;Leonardi et al, 2015;Monzón et al, 2009;Polido et al, 2015;Pucci et al, 2003;Samra et al, 1984). Based on these circumstances, one could speculate that VKC, atopic keratoconjunctivitis, seasonal allergic conjunctivitis, and perennial allergenic conjunctivitis may share pathophysiology and different clinical manifestations of an allergenic disease spectrum.…”

Section: Discussionmentioning

confidence: 98%

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Prevalence of allergic sensitization with vernal keratoconjunctivitis: A systematic review with meta‐analyses

Rasmussen

D’Souza

Topal

et al. 2022

Acta Ophthalmologica

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To determine the prevalence of allergic sensitization in patients with vernal keratoconjunctivitis (VKC) and to provide an overview of published studies on this topic. We systematically searched 11 literature databases on 24 May 2021, for studies with cross‐sectional data on the prevalence of positive allergy tests in patients with VKC. Our main outcome of interest was the prevalence of allergic sensitization and the allergens involved. Prevalence meta‐analyses were made to provide summary estimates. We identified 33 eligible studies for qualitative review with 2122 patients with VKC. Studies were predominantly based on patients seen in ophthalmology clinics. Overall, studies reported that the most prevalent positive allergen tests were the inhaled allergens house dust mites and pollen. Twenty‐nine studies were eligible for the quantitative analysis. Here, we calculated the prevalence of allergen‐positive patients to 57.7% (95% confidence interval: 52.5%–62.8%). Subgroup analyses of pooled estimates on sensitization based on specific testing methods found prevalence estimates of 51.4% for conjunctival provocation test, 68.7% for total tear IgE, 58.9% for specific tear IgE, and 58.2% for skin prick test. The prevalence of allergic sensitization in patients with VKC is 57.7%, and mostly towards inhaled allergens. The most frequent positive allergens are house dust mites and pollen. Identifying possible clinically relevant allergens provide information that may aid in managing VKC, such as environmental allergy‐avoidance or allergy‐specific treatment.

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Section: Discussioncontrasting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Results Of Individual Studiesmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Prevalence of allergic sensitization with vernal keratoconjunctivitis: A systematic review with meta‐analyses

Rasmussen

D’Souza

Topal

et al. 2022

Acta Ophthalmologica

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“…In the present study, there was not found a significant difference between AR patients with allergic conjunctivitis than those without conjunctivitis for the mean IgE levels (p=0.269). In some of the previous studies, it was observed that its levels might increase in ocular allergy compared to the healthy controls (9,11,20). In addition, when patients with high IgE levels were evaluated, no significant difference was found in terms of the frequency of concomitant conjunctivitis in this study (55.3% vs. 50.8%, respectively, p=0.634).…”

Section: Discussioncontrasting

confidence: 56%

Association of complete blood count parameters with IgE levels and disease severity, atopy type in allergic rhinitis patients

Selcuk¹,

Taşkın²

2020

GMJ

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The aim of this study was to investigate the relationship between complete blood count (CBC) parameters and atopy type, disease severity, presence of concomitant conjunctivitis in patients with allergic rhinitis (AR). Methods:In this retrospective study, patients who presented to the immunology and allergic diseases outpatient clinic with rhinitis symptoms and who were found to have proven AR by allergy tests were included. CBC parameters and specific/total immunoglobulin E (IgE) analyses which were measured in the period of active disease were recorded.Results: Totally 242 patients met the enrollment criteria and were included in the study. AR patients with concomitant conjunctivitis had a significantly higher eosinophil count than patients without conjunctivitis (280.13±228.58/mm 3 vs. 231.50±199.92/mm 3 , respectively, p=0.047). The presence of both concomitant pollen and mite atopy was significantly more frequent in the moderate/severe persistent group than in the other groups (p<0.001). Serum total IgE levels were significantly higher in group with patients who had both mite and pollen atopy than in the other groups (168.11±189.27, 149.69±178.21 and 368.53±430.31 IU/ mL, respectively, p=0.005). The presence of conjunctivitis was significantly more frequent in patients with pollen atopy than in patients who did not have (46.9% vs. 30.3%, p=0.021). Conclusions:Although serum eosinophil count and total IgE levels are not sensitive enough in predicting the severity of AR patients, we believe that they can be helpful in diagnosis of patients with concomitant conjunctivitis and in presence of multiple aeroallergen sensitivity.

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Evaluation of allergic sensitization in Lebanese patients with allergic conjunctivitis

et al. 2017

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Correlations Between Allergen-Specific IgE Serum Levels in Patients With Ocular Allergy

Cited by 8 publications

References 34 publications

Prevalence of allergic sensitization with vernal keratoconjunctivitis: A systematic review with meta‐analyses

Prevalence of allergic sensitization with vernal keratoconjunctivitis: A systematic review with meta‐analyses

Association of complete blood count parameters with IgE levels and disease severity, atopy type in allergic rhinitis patients

Evaluation of allergic sensitization in Lebanese patients with allergic conjunctivitis

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