Correlations among KRAS Mutation, Microsatellite Instability, and 18F-FDG Uptake in Colon Cancer

Abstract

Objective: This study aimed to evaluate the correlation of the maximum standardized uptake value (SUVmax) with the Kirsten ras sarcoma viral oncogene (KRAS) mutation and microsatellite instability (MSI) status in colon cancer. Methods: This retrospective study included 195 patients with colon cancer who underwent 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET/CT) before surgery between January 2014 and December 2017. All patients underwent KRAS mutation and MSI analyses using surgical specimens of the primary tumor. The associations of SUVmax with KRAS mutation and MSI were analyzed. Results: The SUVmax differed significantly between the microsatellite stable (MSS) and MSI groups (14.5 ± 7.0 vs. 19.1 ± 10.9; P = 0.0249), and between the KRAS wild-type and KRAS mutation groups (14.1 ± 7.6 vs. 17.5 ± 7.9; P = 0.0017). Conclusions: SUVmax obtained using 18 F-FDG PET/CT showed significant differences in relation to KRAS mutation and MSI status. 18 F-FDG PET/CT could be used as a supplemental modality for assessing KRAS mutations and MSI status in colon cancer.

Evaluation of patients via colonoscopy who underwent positron emission tomography/computerized tomography due to colon involvement

“…Accurate and complete staging is essential for effective treatment. Contrast-enhanced computerized tomography (CT) is frequently used in staging CRCs but it has limitations 3 . These limitations pave the way for fluorodeoxyglucose (FDG) positron emission tomography (PET/CT), a functional imaging method that can provide helpful pre-operative staging and follow-up information.…”