Correlation study between urinary tract bacterial infection and some acute inflammatory responses

AL-Khikani, Falah Hasan Obayes; Auda, Ghusin alban Adnan; Ayit, Aalae Salman

doi:10.4103/bbrj.bbrj_122_19

Cited by 21 publications

(8 citation statements)

References 12 publications

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“…Determination or isolation of one or more culturally identified urinary tract pathogen is considered a definitive diagnosis. [26] E. coli was the most common prevalent pathogen isolated from UTI patients in the current study, E. coli have been implicated in 53 %, this finding accords many studies, [27][28] also agree with [29] that mentioned E. coli prevalence was (42,2 %) in patients with UTI. Followed by Enterobacter species 23% of total urine samples and these findings were in agreement with other respective studies conducted elsewhere.…”

Section: Resultssupporting

confidence: 90%

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Trends in Antibiotic Resistance of Major Uropathogens

AL-Khikani¹

2020

Preprint

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Around the world, there is no population clear from urinary tract infection (UTI), particularly among women. UTI is considered the most predominant bacterial infection. This study aimed to detect the incidence of the most common major uropathogens in patients severe from urinary tract infection with antibiotic sensitivity tests that assist urologist doctors for appropriate antimicrobial empirical therapy.Methods: This study was carried in a private laboratory in Babil city, Iraq from May 2019 to May 2020. Totally 70 individuals suffering from clear symptoms of UTI, as well as, 20 healthy persons participated in this study as a control group. Then, the standard microbiological methods carried out to isolate and identify bacterial species. Antimicrobial susceptibility tests were performed using different antimicrobial discs by applying the Kirby–Bauer disc diffusion method.Results: Totally, 90 specimens were obtained from them 20 control group, 19 with no growth, and 51 patients with bacterial growth distributed as 43 (83%) females and 8 (17%) males. E. coli were the most common predominant organisms. All isolates were showed a high rate of resistance to evaluated cephalosporins 100% and 82% to cefotaxime and ceftriaxone respectively, while very low resistance recorded in Aminoglycosides 20% and 13% to Gentamicin and amikacin respectively. Most age group infected with UTI was 21-40 years old.Conclusion: The current study showed an increasing burden of urinary tract infection caused by various bacteria implicated in UTI that causes changeable sensitivity to various antimicrobial agents. Therefore, in clinical use appropriate medications should be selected based on the data obtained from antimicrobial susceptibility tests.

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Section: Resultssupporting

confidence: 90%

“…[30][31] The age group 21-40 years was the most common infected group 47%. [29] followed by the age group less than 20 years 29%.…”

Section: Resultsmentioning

confidence: 98%

Trends in Antibiotic Resistance of Major Uropathogens

AL-Khikani¹

2020

Preprint

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“…The most common pathogenic bacteria isolates were S. aureus 20 (30%) and E. coli 17 (25%) in all three specimens' types. E. coli was the most common prevalent pathogen isolated from UTI patients in the current study, E. coli have been implicated in 56 samples (45.90%), this finding accords many studies [23,24], also agree with [25] that mentioned E. coli prevalence was (42.2%) in patients with UTI. Followed by Enterobacter species 23% of total urine samples and these findings were in agreement with other respective studies conducted elsewhere [26,27].…”

Section: Discussionsupporting

confidence: 92%

“…In urine specimens, the age group of 21-40 years was the most common infected group 47% [25]. Small aged groups of 1-20 years were most infected aged in ear infections 50%.…”

Section: Discussionmentioning

confidence: 96%

Antimicrobial Resistance Profile Among Major Bacterial Pathogens in Southern Babil, Iraq

AL-Khikani¹

2020

Galician med. j.

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Background: At present, drug-resistant pathogens are considered one of the major increasing causes of morbidity and mortality around the world. The data on microorganisms' resistance assist define the best available treatment for patients. Therefore, this study aimed to screen the antimicrobial-resistant profile of different drugs in major clinical pathogens of urine, ear and wound infections. Methods: This study was conducted in Al-Shomali General Hospital, Southern Babil, Iraq from October 2019 to May 2020. Totally 67 clinical specimens obtained from the wound, urine, and ear discharge collected from hospitalized patients as well as 30 healthy individuals participate in this study. Then, the standard microbiological methods carried outperformed to the isolated and identified bacterial species. Antimicrobial susceptibility tests were performed using different antimicrobial discs by applying the Kirby–Bauer disc diffusion method. Results: Totally, 67 bacterial isolates were obtained from 44 (66%) female and 23 (34%) male patients. Staphylococcus aureus and E. coli were the most common predominant organisms. All isolates were showed a high rate of resistance to evaluated cephalosporins 100% and 87% to cefotaxime and ceftriaxone respectively, while very low resistance recorded in Aminoglycosides 22% and 12% to Gentamicin and amikacin, respectively. Conclusion: These results suggest a constant screening for the detection of antibiotic resistance, as well as developing antimicrobial stewardship programs in Babil, Iraq. Moreover, these bacterial isolates have shown multidrug resistance, mainly to commonly administered drugs that could cause therapy ineffective. Therefore, in clinical use, appropriate treatment should be chosen based on the results obtained from antimicrobial susceptibility tests.

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“…The predominant pathogen causing UTI is Escherichia coli , followed by Staphylococcus saprophyticus , Enterococcus faecalis , and occasionally Klebsiella pneumoniae and Proteus mirabilis [ 5 ]. Clinical manifestations can range from a simple fever with chills to severe sepsis with septic shock, including urethritis, cystitis, pyelonephritis, and bacteriuria, with accompanying symptoms like frequent urination, dysuria, cloudy and foul-smelling urine, suprapubic pain and/or lower abdominal inconvenience and flank pain, causing prolonged morbidity and occasional mortality, depending upon the underlying host and pathogenic risk factors [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%