Correlation Study Between Erythrocyte Acetylcholinesterase Activity, Serum Malondialdehyde and Insulin Sensitivity in Agricultural Workers and Non-agricultural Workers in Nat-Kan Village, Magway Township

Phyu, Mya Pwint; Hlain, Zarchi Theint Theint; Zaw, Thurein; Htway, Soe Minn; Sein, Mya Thanda

doi:10.15605/jafes.035.01.14

Cited by 3 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If it continues, parenchymal and hydropic degeneration will occur, resulting in anaerobic glycolysis and disruption of SERCA in maintaining the function of calcium storage in the cytosol. The increase of calcium storage causes the degradation of nucleic acids, lipids, and proteins, generating necrosis and mitochondrial damage (Illarramendi et al, Karak, 2019;2014;Phyu, et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Shallot Peel Ethanol Extract in Reducing Kidney MDA Levels in Diazinon-induced Wistar Rats

Khoiruddin

Helianti

Hasan

et al. 2022

AMS

View full text Add to dashboard Cite

Diazinon is an organophosphate pesticide often used by farmer. The residue of diazinon may contaminate agricultural products and if accidentally consumed in a long term, may potentially led to health problems such as kidney disorders. Shallot (Allium cepa) peel was recently proposed to help recover the kidney damage due to its high flavonoid antioxidant content. This study aims to determine the antioxidant effect of shallot peel extract in reducing oxidative stress caused by diazinon with malondialdehyde (MDA) level indicator on the kidney of Wistar rats (Rattus norvegicus). This research was a true experimental with an in-vivo posttest-only control group design. The 28 rats were divided using a simple random sampling technique. The groups were the control group (K0), the diazinon group (K1), SPEE (Shallot Peel Ethanol Extract) groups which are P1 (300 mg/kg BW), P2 (600 mg/kg BW), P3 (900 mg/kg BW), P4 (1200 mg/kg BW) and P5 (2400 mg/kg BW). At the end of the study, the MDA kidney levels was analysed using the TBARS method. Effective doses were found in 600 mg/kg BW/day, 900 mg/kg BW/day, 1200 mg/kg BW/day, and 2400 mg/kg BW/day. The optimal dose of shallot peel extract in this study was 600 mg/kg BW/day. This study showed the effectiveness of shallot peel extract in reducing kidney MDA levels in diazinon-induced Wistar rats. Keywords: shallot peel, diazinon, kidney MDA level

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Shallot Peel Ethanol Extract in Reducing Kidney MDA Levels in Diazinon-induced Wistar Rats

Khoiruddin

Helianti

Hasan

et al. 2022

AMS

View full text Add to dashboard Cite

show abstract

“…On the other hand, increased MDA levels are a marker of oxidative stress and has been shown to indicate antioxidant status in cancer patients. An increase in MDA levels is frequently seen in patients exposed to pesticides [114].…”

Section: Role Of Pesticides In Oncogenesismentioning

confidence: 99%

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

Lucchesi,

Vasilatis,

Mantrala

et al. 2023

IJMS

View full text Add to dashboard Cite

Multiple risk factors have been associated with bladder cancer. This review focuses on pesticide exposure, as it is not currently known whether agricultural products have a direct or indirect effect on bladder cancer, despite recent reports demonstrating a strong correlation. While it is known that pesticide exposure is associated with an increased risk of bladder cancer in humans and dogs, the mechanism(s) by which specific pesticides cause bladder cancer initiation or progression is unknown. In this narrative review, we discuss what is currently known about pesticide exposure and the link to bladder cancer. This review highlights multiple pathways modulated by pesticide exposure with direct links to bladder cancer oncogenesis/metastasis (MMP-2, TGF-β, STAT3) and chemoresistance (drug efflux, DNA repair, and apoptosis resistance) and potential therapeutic tactics to counter these pesticide-induced affects.

show abstract

“…(Lwin et al 2017) studied chronic exposure related to OP dose may reduce potential male reproductivity in Myanmar. Likewise, impacts of chronic low dose OP exposure on respiratory health and function decline, OP exposure have a significant negative correlation between the oxidative street and the development of insulin resistance (Phyu, Hlain et al 2020) and chronic low-level exposure to OP pesticides has harmful effects on the cardiovascular systems (Thandar, Naing et al 2021)…”

Section: Impact Of Pesticide Use On Human Healthmentioning

confidence: 99%

“…Only (9%) felt nervous was the most occurrence symptom of depressive/anxious thoughts related to pesticide exposure from late October to mid-February in 2021 of rice production There is an evidence study by Mya Pwint Phyu that in 2020 that pointed out organophosphate pesticide exposure lowered Erythrocyte acetylcholinesterase AChE activity and increases oxidative stress and contribute to the development of insulin resistance in agricultural workers in Myanmar. (Phyu, Hlain et al 2020).…”

Section: Health Problems Related To Pesticide Exposurementioning

confidence: 99%

The potential risk and occupational exposure of pesticides among rice farmers in delta Ayeyarwady division, Myanmar

Khin

View full text Add to dashboard Cite

This study aims to assess the potential risk and occupational exposure of pesticides among rice farmers in the Delta Ayeyarwady Region, Myanmar. A cross-sectional study was carried out with 454 rice farmers from�March-April 2022. Data collection was done through face-to-face interviews used with a semi-structured questionnaire. The study showed that the mean age of farmers was 44.36 years old while the range was 16 and 74 years old. Rice farmers' average weight (? standard deviation) was 56.86 (? 7.30) kg. In this study, over two-thirds of the rice farmers (77 %) had a moderate level of knowledge regarding environmental awareness related to pesticides, exposure, and toxicity of pesticides. Likewise, almost rice farmers in the participants (94 %) had a moderate practice level regarding pesticide handling, management, storage, and hygiene. Regarding potential of risk assessment, in the cross-sectional study of rice farmers in Ayeyarwady, (87%) of the respondents applied insecticides while 73 % and 29% were herbicides and fungicides users, accordingly. For determination of health risk assessment, inhaling a large amount of organophosphate group (acephate, chlorpyrifos, and dimethoate, pyrethroids group (Lambda-Cyhalothrin and cypermethrin) and carbonate group (carbofuran and cartap hydrochloride) during loading, mixing, and spraying of these pesticides without proper respirators. To evaluate the potential occupational exposure of rice farmers in this community, the mean average daily dose (ADD) of acephate, chlorpyrifos, and dimethoate of the organophosphate group was 8? 10-3 mg/kg-day, 1.53 ? 10-3 mg/kg-day and 7.91 ? 10-3 mg/kg-day, pyrethroid group of cypermethrin 1.91 ? 10-3 mg/kg-day and lambda-cyhalothrin 1.26? 10-4 mg/kg-day, and carbonate group of carbofuran and cartap Hydrochloride of rice farmers at 2.27? 10-3 mg/kg-day and 9.6?10-4 mg/kg-day, respectively. To characterize non-cancer risk, a hazard quotient (HQ) was applied. The HQ for the organophosphate group of chlorpyrifos acute and sub-chronic exposures was 5.1 times while 23.93 times was chronic exposure exceeded the acceptable level (greater than 1) in both short-term and long-term. In conclusion, there has a higher potential of inhalation exposure for rice farmers in Ayeyarwady, Delta Region in Myanmar might be exposed to chlorpyrifos of organophosphate group in pesticide application. Regarding, health adverse effects related to pesticide exposure, most of the rice farmers in the study areas suffered acute symptoms was dizziness accounted for 239 (53%). Likewise, (31.8%) of rice farmers suffered from dizziness as a sub-chronic symptom within one month after application of the pesticide. In addition, subjective signs, and symptoms related to pesticide exposure (14%) of the participants often suffered headaches, and (9%) feeling nervous were the most occurrence symptoms.�

show abstract

Correlation Study Between Erythrocyte Acetylcholinesterase Activity, Serum Malondialdehyde and Insulin Sensitivity in Agricultural Workers and Non-agricultural Workers in Nat-Kan Village, Magway Township

Cited by 3 publications

References 31 publications

The Effect of Shallot Peel Ethanol Extract in Reducing Kidney MDA Levels in Diazinon-induced Wistar Rats

The Effect of Shallot Peel Ethanol Extract in Reducing Kidney MDA Levels in Diazinon-induced Wistar Rats

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

The potential risk and occupational exposure of pesticides among rice farmers in delta Ayeyarwady division, Myanmar

Contact Info

Product

Resources

About