Correlation research between osteoporosis and left ventricular hypertrophy in older men

Huang, Chenshu; Li, Shaolin

doi:10.5114/aoms.2016.62910

Cited by 3 publications

(4 citation statements)

References 19 publications

(17 reference statements)

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“…Epidemiological studies [ 8 ] also showed that osteoporosis and osteopenia were risk factors for cardiovascular disease or atherosclerosis disease. In the general female population and older men, BMD was shown to be an independent factor determining LVMI [ 9 , 10 ]. In the study by Hisashi et al.…”

Section: Discussionmentioning

confidence: 99%

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Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients

Sun,

Zhang,

Liu

et al. 2024

Renal Failure

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Background The assessment of left ventricular (LV) remodeling and its association with mineral and bone disorder (MBD) in kidney transplant recipients (KTRs) have not been systematically studied. We aimed to evaluate LV remodeling changes one year after kidney transplantation (KT) and identify their influencing factors. Methods Ninety-five KTRs (68 males; ages 40.2 ± 10.8 years) were followed before and one year after KT. Traditional risk factors and bone metabolism indicators were assessed. Left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF) and left ventricular diastolic dysfunction (LVDD) were measured using two-dimensional transthoracic echocardiography. The relationship between MBD and LV remodeling and the factors influencing LV remodeling were analyzed. Results One year after KT, MBD was partially improved, mainly characterized by hypercalcemia, hypophosphatemia, hyperparathyroidism, 25-(OH) vitamin D deficiency, elevated bone turnover markers, and bone loss. LVMI, the prevalence of left ventricular hypertrophy (LVH), and the prevalence of LVDD decreased, while LVEF increased. LVH was positively associated with postoperative intact parathyroid hormone (iPTH) and iPTH nonnormalization. △LVMI was positively associated with preoperative type-I collagen N-terminal peptide and postoperative iPTH. LVEF was negatively associated with postoperative phosphorous. △LVEF was negatively associated with postoperative iPTH. LVDD was positively associated with postoperative lumbar spine osteoporosis. Preoperative LVMI was negatively associated with △LVMI and positively associated with △LVEF. Advanced age, increased BMI, diabetes, longer dialysis time, lower albumin level, and higher total cholesterol and low-density lipoprotein levels were associated with LV remodeling. Conclusions LV remodeling partially improved after KT, showing a close relationship with MBD.

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Section: Discussionmentioning

confidence: 99%

“…For the non-CKD population, a close relationship has been observed between cardiovascular disease and osteoporosis [ 8 ]. Bone mineral density (BMD) has been demonstrated to be an independent determinant of LVMI in the general population [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients

Sun,

Zhang,

Liu

et al. 2024

Renal Failure

View full text Add to dashboard Cite

show abstract

“…There may be a correlation between the osteoporosis and other diseases such as left ventricular hypertrophy (LVH) [17].…”

Section: Discussionmentioning

confidence: 99%

“…There may be a correlation between osteoporosis and other diseases such as left ventricular hypertrophy (LVH) [ 17 ]. Osteoporosis mainly results from an imbalance between osteoblastogenesis and osteoclastogenesis.…”

Section: Discussionmentioning

confidence: 99%

MALAT1/miR-320a in BMSC function may inform on mechanisms underlying osteoporosis

Wang

et al. 2021

Arch Med Sci

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Introductiongrowing evidence supports the involvement of long noncoding RNAs (lncRNAs) in bone metabolism and diseases. This study aims to investigate the involvement of the lncRNA MALAT1 in the pathological process of osteoporosis and the effects of MALAT1 on the regulation of BMSC differentiation through competitive endogenous RNA (ceRNA) mechanisms.Material and methodsthe expression of MALAT1 and miR-320a was determined using RT-PCR in bone tissue derived from female SD(Sprague Dawley) rats with osteoporosis. Immumohistochemical staining (IHC) was used to evaluate the expression of neuropilin-1 (NRP-1) and β-catenin. BMSCs were divided into 4 groups: Control, NC (Negative control), MALAT1 siRNA, and miR-320a mimics. Fourty-eight hours later, the effect of MALAT1 on the miR-320a expression, proliferation and osteogenic differentiation of BMSCs was investigated. Two weeks later, the cell activity, alkaline phosphatase (ALP) activity, and mRNA expression of Osterix and Runx2 were evaluated. Three weeks later, alizarin red staining of calcified nodules and Western blot analysis of the expression of β-catenin, NRP-1, osteocalcin (OCN), osteopontin (OPN) were performed.Resultsdownregulated MALAT1 or upregulated miR-320a expression inhibited the activity and osteogenic differentiation of BMSCs, resulting in low ALP activity and NRP-1 expression, fewer calcified nodules, decreased mRNA levels of Osterix and Runx2, and inhibited expression of NRP-1, OCN, and OPN. MALAT1 silencing did not decrease the protein level of β-catenin in the cytoplasm but suppressed that in the nucleus.Conclusionsdownregulated MALAT1 and upregulated miR-320a expression play an important role in the pathological process of osteoporosis, via inhibition of the osteogenic differentiation of BMSCs.

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Serum TRACP5b, a Marker of Bone Resorption, Is Associated With Adverse Cardiac Prognosis in Hospitalized Patients With Heart Failure

et al. 2021

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Correlation research between osteoporosis and left ventricular hypertrophy in older men

Cited by 3 publications

References 19 publications

Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients

Left ventricular remodeling and its association with mineral and bone disorder in kidney transplant recipients

MALAT1/miR-320a in BMSC function may inform on mechanisms underlying osteoporosis

Serum TRACP5b, a Marker of Bone Resorption, Is Associated With Adverse Cardiac Prognosis in Hospitalized Patients With Heart Failure

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