Correlation of Wnt-2 expression and β-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination

Cheng, Xiaoxin; Wang, Zi-Chuang; Chen, Xiaoyan; Sun, Yuan; Kong, Qing‐You; Liu, Jia; Li, Hong

doi:10.1016/j.canlet.2004.11.013

Cited by 73 publications

(67 citation statements)

References 26 publications

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“…The overexpression of Wnt-2 was associated with cytoplasmic/nuclear b-catenin accumulation both in intestinal-and diffuse-type gastric carcinoma, and positively associated with increased metastatic potential [70] . Furthermore, the upregulation of Wnt-1 ligand was found playing an important role either in cellular proliferation of GCSC and in advanced gastric cancer [47,71] .…”

Section: Gain Of Wnt Activator Function In Gastric Cancermentioning

confidence: 92%

“…Members of the Wnt family protein, such as Wnt-1, Wnt-2 and Wnt-2B have been found upregulated in gastric cancer [47,[69][70][71] . The overexpression of Wnt-2 was associated with cytoplasmic/nuclear b-catenin accumulation both in intestinal-and diffuse-type gastric carcinoma, and positively associated with increased metastatic potential [70] .…”

Section: Gain Of Wnt Activator Function In Gastric Cancermentioning

confidence: 99%

“…Homeostasis of the gastrointestinal epithelium is 87 [47,[69][70][71][72][73][74][75]232] Fzd-3 [78] CTNNB1 [9,[88][89][90][91][92][93]96,97] LRP6 [228] TCF7L2 [98][99][100] PPN [79] CDH17 [80] EZH2 [81] HMGA1, HMGA2 [210,211] YY1 [86] TC1 (C8orf4) [201,202] miR-17-92 [161] mir-10a [168] has-miR-335 [166] hsa-miR-375 [163] Downregulation or function inhibition in gastric cancer Downregulation by hypermethylation Inactivation by miRNAs APC [145,146] APC [175] sFRP1, sFRP2, sFRP4, sFRP5 [78,96,149] AXIN2 [159] WIF-1 [144,149] EZF1 [78] Dkk-1, Dkk-2, Dkk-3 [59,144,148,…”

Section: Wnt/b-catenin Pathway In Gastric Carcinogenesismentioning

confidence: 99%

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Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Chiurillo

2015

WJEM

262

230

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Gastric cancer remains one of the most common cancers worldwide and one of the leading cause for cancerrelated deaths. Gastric adenocarcinoma is a multifactorial disease that is genetically, cytologically and architecturally more heterogeneous than other gastrointestinal carcinomas. The identification of specific membrane, intracellular, and extracellular components of the Wnt pathway has revealed potential targets for gastric cancer therapy. High-throughput "omics" approaches will help in the search for Wnt pathway antagonist in the near future.

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Section: Gain Of Wnt Activator Function In Gastric Cancermentioning

confidence: 92%

Section: Gain Of Wnt Activator Function In Gastric Cancermentioning

confidence: 99%

Section: Wnt/b-catenin Pathway In Gastric Carcinogenesismentioning

confidence: 99%

See 1 more Smart Citation

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Chiurillo

2015

WJEM

262

230

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“…In contrast to the previous studies that have focused on single pathways [18][19][20], experimental evidence indicates that, in most cases, carcinogenesis is dictated by complex interactions between multiple pro-and anti-oncogenic signaling pathways [21].…”

Section: Oncogenic Pathway Combinations Predict Outcome Of Gastric Camentioning

confidence: 76%

“…They developed an in silico technique to deine activation levels of diferent oncogenic pathways implemented in context of complex tumor proiles and validated this classiication approach using proof-of-concept examples from breast cancer. Afterward, they have applied this method to gastric tumors and evaluated 11 oncogenic pathways previously known to be involved in gastric tumorigenesis [16][17][18][19][20][24][25][26][27]. They have assessed over 300 primary stomach cancers coming from three independent patient cohorts.…”

Section: Oncogenic Pathway Combinations Predict Outcome Of Gastric Camentioning

confidence: 99%

Molecular Prognostic Factors in Gastric Cancer

Lazăr¹,

Tăban²,

Cornianu³

et al. 2017

Gastric Cancer

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Gastric cancer represents a major health problem worldwide. Literature data have demonstrated that gastric tumors present a high molecular heterogeneity, responsible for the process of carcinogenesis and dissemination. By revealing the molecular subtype of the tumor, it is possible to assess its behavior, the outcome of the patient, and the treatment approach, according to its genetic and epigenetic proile. This chapter aims to highlight some of the many diferent genetic mutations, epigenetic alterations, as well as aberrant signaling pathways involved in the pathogenesis of stomach cancers, each of these molecular abnormalities acting in a speciic stage of the disease. Moreover, the manuscript describes the novel therapeutic agents that target some of these aberrant molecular signaling pathways. Unfortunately, only a few agents are currently part of the standard treatment of gastric cancer, while most of the others remain to prove their therapeutic eicacy in the seting of clinical trials. By discovering the diferent molecular subtypes of gastric cancer, as well as numerous classes of targeted molecular agents, in the future, we would be able to perform an individualized treatment, associated with maximum eiciency and less costs.Keywords: gastric cancer, molecular classiication, gene expressions-based prognostic scoring system, molecular biomarkers, molecular targeted treatment IntroductionDespite a decline in the incidence in past decades, gastric cancer remains a major health problem globally [1,2], being the ifth most common type of cancer worldwide, with almost one million new cases estimated to have occurred in 2012, according to Globocan [3]. Furthermore, stomach cancer represents the third leading cause of cancer death in both sexes worldwide (723,000 deaths) [3].© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.According to the World Health Organization classiication, the vast majority of gastric cancers are adenocarcinomas, divided into papillary, tubular, mucinous (colloid), and poorly cohesive carcinomas (including signet-ring cell carcinoma and other variants) [4]. Although it was proposed a long time ago (1965), the Lauren classiication is still widely used in clinical practice and subdivides gastric carcinomas into intestinal and difuse types, associated with diferent pathogenesis, ways of spreading, and outcome [5]. Unfortunately, these two classiication systems have litle clinical impact, making the development of classiiers that can deine prognosis and guide patient's treatment as an urgent need.Literature data have demonstrated that the development of gastric cancer is associated in the majority of cases with infectious agents such as the Gram-negative spiral bacterium Helicobacter pylori (most often) [6] and Epstein-Barr virus (EBV) (about 9% o...

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Hepatocyte Growth Factor Induces Invasion and Migration of Ovarian Cancer Cells by Decreasing the Expression of E‐cadherin, β‐catenin, and Caveolin‐1

Shao

Song

et al. 2010

The Anatomical Record

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Distant metastases are unusual occurrences at presentation and during the progression of epithelial ovarian cancer. There are no good clinical predictors of this phenomenon. In this study, we examined the role of hepatocyte growth factor (HGF) in cell metastasis in ovarian cancer HO8910 cells. We found that HGF has functions in biological processes essential to metastasis, including morphological remodeling, invasion and migration (P ¼ 0.000, P ¼ 0.001). Western blotting showed that in HGF treated group, the expression of E-cadherin, b-catenin, and caveolin-1 was decreased as compared with the control group (P ¼ 0.000, P ¼ 0.002, P ¼ 0.000). Immunofluorescence staining demonstrated that the population of E-cadherin, b-catenin, and caveolin-1 at the cell membrane was downregulated. Reverse transcriptase polymerase chain reaction analysis revealed the decreased expression of E-cadherin, b-catenin, and caveolin-1 at the mRNA level. Our data indicated that HGF leads to downregulation of E-cadherin, b-catenin, and caveolin-1, disassembly of cell-cell contacts, and invasion and migration enhancement in human ovarian cancer cells. Anat Rec, 293:1134Rec, 293: -1139

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Correlation of Wnt-2 expression and β-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination

Cited by 73 publications

References 26 publications

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

Molecular Prognostic Factors in Gastric Cancer

Hepatocyte Growth Factor Induces Invasion and Migration of Ovarian Cancer Cells by Decreasing the Expression of E‐cadherin, β‐catenin, and Caveolin‐1

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