Correlation of Vitamin D3 (Calcitriol) Serum Concentrations with Vitamin B12 and Folic Acid in Women Undergoing in vitro Fertilisation/Intracytoplasmatic Sperm Injection

Rogenhofer, Nina; Mann, Christopher H.; Gluderer, J; Schönfeldt, Viktoria von; Jeschke, Udo; Thaler, Christian J.

doi:10.1159/000493138

Cited by 12 publications

(13 citation statements)

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“…Our data are in line with several in vitro and in vivo studies reporting seasonal dynamic of D3 and the impact on AMH [1]. However, our ndings show a parallel 3-month dynamic as AMH with peak levels of both, D3 and AMH delayed from August to end of October, supporting the hypothesis of our pilot study suggesting a prolonged tissue storage with a following slow release of D3 [36]. Here, in addition, a similar quartile dynamic was found in the ART outcome with best results from August to end of October.…”

Section: Discussionsupporting

confidence: 92%

“…We could con rm and amend the results of our pilot study by Rogenhofer et al [36] showing statistically signi cant 3-month quartile changes of D3 serum concentrations (p < 0.0001) registering the maximum level from 1st August to 31th October with a mean of 27.7 mg/dl. The lowest expression was noted from 1st February to 30th April with a mean of 20.9 mg/dl (Fig.…”

Section: Vitamin D Dynamicsupporting

confidence: 60%

“…Up to now there are no data analysing seasonal 3-month changes of D3 with regard to AMH and ART (Assisted Reproductive Technologies i.e invitro fertilisation (IVF), intracytoplasmatic sperm injection (ICSI)) outcome. Just since we reported in our pilot study 3-month uctuations of D3 serum concentrations with delayed peak in autumn (August to end of October) postulating a prolonged tissue storage with a following slow release of D3 resulting in a delay of the D3 de ciency [36].…”

Section: Introductionmentioning

confidence: 72%

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Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI

Rogenhofer¹,

Jeschke²,

Schönfeldt³

et al. 2021

Preprint

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Objective:Recent studies revealed intriguing associations between cholecalciferol (D3) and reproductive functions. Seasonal changes of D3 concentrations are well known, however they are not always considered in the context of reproductive functions. In this study, we analysed D3 serum concentration in IVF/ICSI patients with respect to seasonal 3-month quartiles and anti-Muellerian hormone (AMH) referring to the impact on Assisted Reproductive Technologies (ART) outcome. Materials and Research Methods:We studied 497 female patients, presenting between 2012 and 2018 for ART treatment in our fertility center. D3 as well as the AMH serum concentrations were measured at the beginning of the follicle stimulation (d 3-5 of menstrual cycles). Results were evaluated with respect to seasonal quartiles and outcome of the ART cycles. Results:D3 concentrations showed significant fluctuations within annual quartiles with a pronounced peak in August-October and a minimum in February-April (27.7mg/dl vs. 20.9mg/dl; p<0.0001). Similar seasonal dynamics were found for AMH (3.19ng/ml vs. 2.24ng/ml; p=0.013) and these were associated with significantly shorter stimulation periods during August-October (11.36d vs. 12.01d; p=0.044), higher number of fertilized oocytes between August-October (6.21 vs. 5.21; p=0.05) along with a trend towards higher numbers of Cumulus-Oocyte-complexes. However, no such differences were found for the numbers of MII-oocytes or pregnancy rates.Conclusion: Our data indicate, seasonal 3-month quartile variations of AMH concentrations and characteristics of ART, such as days of ovarian stimulation and number of fertilised oocytes. Highest AMH concentrations were found between August and October and this quartile was associated with highest D3 concentrations.

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Section: Discussionsupporting

confidence: 92%

Section: Vitamin D Dynamicsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 72%

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Seasonal Dynamic of Cholecalciferol (D3) And Anti-Muellerian Hormone (AMH) With Impact On Ovarian Response And IVF/ICSI

Rogenhofer¹,

Jeschke²,

Schönfeldt³

et al. 2021

Preprint

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“…In a study of middle-aged women, vitamin D and vitamin B12 levels were reported to be related independent from fat mass of individuals (29). In a study by Rogenhofer et al, a high correlation between vitamin D levels and vitamin B12 levels was reported (30).…”

Section: Biochemical Resultsmentioning

confidence: 95%

Evaluation of obesity with vitamin d levels and related parameters

Kayacan¹

2019

Erciyes Med J

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This study aimed to investigate the relationship between vitamin D levels, biochemical findings, and body analysis data of adult individuals, and effects of seasonal vitamin D level differences on these relationships. Materials and Methods:In this retrospective study, medical records of 159 individuals who applied to Samsun Büyük Anadolu Hospital Nutrition and Dietary Polyclinic were examined. The serum 25(OH)D levels were defined as <10 ng/ml vitamin D deficiency; 10-20 ng/ml vitamin D insufficiency; and >20 ng/ml normal vitamin D level. Vitamin D levels were also divided into two according to seasons: summer and winter.Results: Of the 159 participants included in the study, 42 were overweight and 94 were obese. Vitamin D deficiency was found in 21.4% and vitamin D insufficiency was found in 35.2% of the patients. Winter vitamin D levels were significantly lower than summer vitamin D levels. Vitamin D levels decreased with increasing body fat mass and percentage, abdominal fat mass and percentage. Individuals with vitamin D deficiency had higher body mass index than individuals with vitamin D insufficiency. Vitamin B12 levels of individuals with vitamin D deficiency were found to be significantly lower. Aspartate aminotransferase levels of individuals with vitamin D deficiency were higher than individuals with vitamin D insufficiency. Conclusion:Vitamin D deficiency and insufficiency varies according to sunbathing times in summer and winter season and it is quite common in obese patients. Strategies should be developed to prevent and control obesity and to combat the inadequacy of vitamin D nutritional status.

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“…Наукові дослідження вчених Університету Торонто показали, що у жінок з передменструальними симптомами, які відчувають до 95% жінок, недостатній рівень 25(OH)D може бути пов'язаний з їх тяжкістю [5,6]. Результати низки досліджень, проведених в Україні, свідчать, що нестачу та дефіцит вітаміну D реєструють більш ніж у 80% дорослого населення і лише у 6-7% жінок різного віку виявляють нормальний рівень вітаміну D [7]. Виділяють ряд захворювань, пов'язаних з недостатністю вітаміну D, які дуже впливають на здоров'я і якість життя жінки.…”

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