Correlation of Vitamin D Status with Lipid Profile of Outpatient Department Attendees - A Cross Sectional Study in a Rural Tertiary Care Hospital of North Bengal, India

Abstract

BACKGROUND Deficient or insufficient vitamin D status is found as a major chunk amongst all age groups all over the Indian subcontinent. Low levels of serum 25 (OH) D are associated with atherogenic lipid profile, and the resultant dyslipidemia is an important risk factor for cardiovascular disease and other atherosclerotic disorders in adults. As, not much literature was available on the deficiency of vitamin D and its effects, in the North Bengal region of West Bengal, India, this study was done to find out the association between vitamin D status and lipid profile of the participants and predict the risk of dislipidaemia with changes in vitamin D status. METHODS 430 medicine OPD attendees were selected for the study, interviewed after taking consent, blood parameters were examined and collected data were analysed for correlation and multinomial regression using SPSS v.25. RESULTS The mean value and standard deviation of serum 25 (OH) D level was found to be 21.53 ± 7.06 ng / ml. 35 % of vitamin D deficient subjects were found to be dyslipidemic. A negative correlation was observed between vitamin D status and total cholesterol & LDL status. While vitamin D status changed from “Sufficient” to “Deficient”, the chance of dyslipidemia increased by approximately 4.6 times. CONCLUSIONS Serum vitamin D influences largely the lipid profile of the study population. KEY WORDS Vitamin D, Serum 25 (OH) D, Dyslipidaemia, Cholesterol