Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome

Abstract

Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.

<p>Triglycerides and Total Cholesterol Concentrations in Association with Hyperuricemia in Chinese Adults in Qingdao, China</p>

“…At present, the epidemiological studies of dyslipidemia (elevated TG and TC) and HUA have been reported. Some studies showed that elevated UA was associated with high TG, TC, low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C), and low HDL-C, [23][24][25][29][30][31] which did not confirm a causal role for HUA and dyslipidemia. Matsuura et al 32 pointed out that an increase in UA level could be the signal for overfeeding behavior and fat storage in Wistar rats, and then, elevated UA level could act on the urinary bladder mucosa and increases the level of triglyceride and total cholesterol by fructose-induced.…”

Antioxidant Activity of Uric Acid and its Correlation with Oxidative Stress and Endothelial Dysfunction in Type 2 Diabetes Mellitus

“…An earlier cross-sectional study has found that uric acid levels are associated with HDL-c and triglycerides than insulin resistance in dyslipidaemia subjects. Where, atherogenic index of plasma was found to be signi cantly correlated with uric acid [8]. Moreover, Posthoc analysis of GREACE and the life trials changed interest to focus on serum uric acid level and its contribution in atherosclerotic cardiovascular disease [9].…”

The interaction between serum uric acid and triglycerides level on blood pressure in middle-aged and elderly individuals in China: result from a large national cohort study

“…In recent years, as a critical mark, systemic measured by SUA has become an essential marker for chronic disease development. Studies have conducted that SUA is associated with various diseases, such as CVDs [22][23][24][25], prehypertension [26][27][28][29], metabolic syndrome [30][31][32], and hypertension [33][34][35]. However, despite the association between SUA level and these risk conditions, SUA level may not be regarded as an independent risk factor.…”