Correlation of two bioadhesion assays: the everted sac technique and the CAHN microbalance

Santos, Camilla A.; Jacob, Jules S.; Hertzog, Benjamin; Freedman, B.; Press, D.L; Harnpicharnchai, P; Mathiowitz, Edith

doi:10.1016/s0168-3659(99)00109-1

Cited by 72 publications

(27 citation statements)

References 24 publications

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“…It has been used since 1954 to study intestinal transport. Santos et al (1999) applied this method on mucoadhesion assays. It is easy to reproduce and can be performed in almost all laboratories.…”

Section: Techniques Utilizing Gut Sac Of Ratsmentioning

confidence: 99%

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Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

247

181

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Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.Uniterms: Mucoadhesion. Bioadhesion. Mucoadhesive systems. Drugs/delivery. O efeito de fármacos pode ser potencializado através do desenvolvimento de novos sistemas de liberação como os sistemas mucoadesivos. Estes sistemas permanecem em contato íntimo com o tecido de absorção, as mucosas, liberando o fármaco no local de ação, com o consequente aumento da biodisponibilidade, podendo promover efeitos locais e sistêmicos. A mucoadesão, atualmente, é explicada por seis teorias, a eletrônica, da adsorção, da molhabilidade, da difusão, da fratura e a mecânica. Para estudar seus mecanismos e quantificá-la, são propostas várias metodologias in vitro e in vivo. Porém, a mucoadesão ainda não é totalmente compreendida. Esse trabalho tem por objetivo revisar os mecanismos e as teorias envolvidas na mucoadesão, além de descrever as metodologias e os polímeros mais utilizados em sistemas mucoadesivos para liberação de fármacos.Unitermos: Mucoadesão. Bioadesão. Sistemas mucoadesivos. Fármacos/liberação.

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Section: Techniques Utilizing Gut Sac Of Ratsmentioning

confidence: 99%

“…The sacs are introduced into tubes containing the system under analysis at known concentrations, stirred, incubated and then removed. The percent adhesion rate of the release system onto the sac is determined by subtracting the residual mass from the initial mass (Santos et al, 1999).…”

Section: Techniques Utilizing Gut Sac Of Ratsmentioning

confidence: 99%

Mucoadhesive drug delivery systems

Carvalho

Bruschi

Evangelista

et al. 2010

Braz. J. Pharm. Sci.

247

181

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“…The instrument measures the mucoadhesive force between mucosal tissue and a single microsphere mounted on a small diameter metal wire suspended from the sample loop in microtesiometer. 47) The tissue, usually rat jejunum, is mounted within the tissue chamber containing Dulbecco's phosphate buffered saline containing 100 mg/dl glucose and maintained at the physiologic temperature. The chamber rests on a mobile platform, which is raised until the tissue comes in contact with the suspended microsphere.…”

Section: Tensile Stress Measurement Wilhelmy Plate Techniquementioning

confidence: 99%

“…The CAHN technique and the everted intestinal sac technique, both predict the strength of mucoadhesion in a very similar manner. Santos et al 47) established a correlation between the two in vitro mucoadhesion assay methods which thereby allows one to confidentially utilize a single mucoadhesion assay to scan a variety of mucoadhesive polymers.…”

Section: )mentioning

confidence: 99%

Mucoadhesive Microspheres for Controlled Drug Delivery

Chowdary

Rao

2004

Biological & Pharmaceutical Bulletin

152

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Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The objective of this article is review the principles underlying the development and evaluation of mucoadhesive microspheres and the research work carried out on these systems.

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“…Esta metodologia pode ser uma ferramenta potencial para os estudos de mecanismos e cinética de absorção de fármacos, devido ao baixo custo e à simplicidade de sua aplicação. (Rowland, Woodley, 1981;Barthe et al, 1998;Santos et al, 1999;Chen et al, 2003).…”

Section: Intestino Invertidounclassified