Correlation of Tumor Markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 With Survival and Metastasis in Laryngeal Squamous Cell Carcinoma

Spafford, Michael; Koeppe, John; Pan, Zhaoxing; Archer, Philip G.; Meyers, Arlen D.; Franklin, Wilbur A.

doi:10.1001/archotol.1996.01890180035010

Cited by 131 publications

(100 citation statements)

References 18 publications

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“…Study by Chen suggested that CD44v6/v7 expression might be a prognostic indicator in patients with acute promyelocytic leukemia (Chen et al, 2012 consistent with longer survival in laryngeal squamous cell carcinoma patients. In lung cancer, the present studies showed CD44v6 may play an important role in lung carcinoma histogenesis and in determining the fate of neoplastic differentiation (Spaford et al, 1996). Afify et al found CD44v6 expression was more significantly associated with tumor size in lung cancer (Afify et al, 2011).…”

Section: Discussionsupporting

confidence: 50%

Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis

He¹,

Qiu²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 50%

Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis

He¹,

Qiu²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…17) Moreover, the down-regulation of CD44v6 has also been reported to be related with malignant changes in the epithelium 23,24) in HNSCCs. In addition, other reports have described a correlation between a down-regulated expression of CD44v6 18,25) or CD44st, 18) and regional lymph node metastasis in HNSCCs. Based on these findings, it appears that the expression pattern of CD44v varies according to the involved organ, and therefore some organ specificity appears to exist regarding CD44v expression.…”

Section: Discussionmentioning

confidence: 90%

“…16) Other reports show that the expression of CD44st is associated with longer survival in neuroblastoma 17) and that down-regulation of CD44v6 is associated with shorter survival in laryngeal squamous cell carcinoma. 18) We have proved that down-regulation of CD44v2 was correlated significantly with poorer prognosis in esophageal squamous cell carcinoma.…”

mentioning

confidence: 79%

Clinicopathological Significance of Expression of CD44 Variants in Head and Neck Squamous Cell Carcinoma

Kanke

Fujisawa

Kameyama

et al. 2000

Japanese Journal of Cancer Research

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Splice variants of the cell surface glycoprotein CD44 have been reported to be associated with the progression of various human tumors. The aim of this study is to determine the correlation between the expression of CD44 isoforms, especially CD44 variant 2 (CD44v2), and the clinicopathological features of head and neck squamous cell carcinomas (HNSCCs). The expression of CD44 isoforms was evaluated immunohistochemically in paraffin-embedded tissues from 89 primary lesions, using monoclonal antibodies against CD44 standard (CD44st), CD44 variant 6 (CD44v6) and CD44v2. Cancer tissues from 89 (100%), 85 (95.5%) and 59 (66.3%) patients showed positive immunoreactivity for CD44st, CD44v6 and CD44v2, respectively. A significant correlation was observed between the down-regulation of CD44v2 and poorer differentiation of the tumor cells (P = = = =0.02). We could not find any significant correlation between the expression of CD44v2 and T stage or N stage (lymph node status). However, the rate of positive cervical lymph node metastasis tended to increase with reduced expression of CD44v2 (P = = = =0.08). Down-regulation of CD44v2 expression was correlated with shorter overall survival (P = = = =0.01). Furthermore, Cox's multivariate analysis revealed that only CD44v2 expression and lymph node status were independent prognostic factors. These findings suggest that down-regulation of CD44v2 expression may be one of the biological markers for the degree of malignancy in HNSCCs.

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“…Nevertheless, this is a controversial issue, with other researchers reporting a relationship between these proteins and survival (9,(18)(19)(20)53). In contrast, there is a wide consensus that loss of CD44 expression is an adverse prognostic factor in head and neck cancer (30,33,37,54,55). We believe that absent or low expression of the proteins p21 WAF1/CIP1 and p16 INK4a may contribute to carcinogenesis by preventing progression from G1 to S phase of the cell cycle.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer

González‐Moles

Gil-Montoya²,

Ruiz‐Ávila³

et al. 2007

Oncol Rep

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Abstract. The role of lost or reduced expression of p21, p16 and CD44s in the survival of tongue cancer patients was investigated. Tumours and adjacent non-tumour epithelia (ANTE) from 36 patients with tongue cancer were retrospectively studied by immunohistochemistry using monoclonal antibodies against p21, p16 and CD44s proteins. Expression of p21, p16 and CD44s and their relationship with clinical and pathological parameters were analyzed. Of 36 patients, 12 (33.33%) developed recurrence and 12 died of the disease (mean survival, 25.5 months). In four cases (11.1%), concomitant low expression (<50% of tumour cells) of p21, p16 and CD44s was detected but had no effect on survival or recurrence in the univariate analysis. In the multivariate analysis, low expression of CD44s was the sole prognostic factor related to survival (p=0.01, hazards ratio: 0.749). There was no expression of p21, p16 or CD44s in ANTE from 3 out of 24 cases studied, and this finding was related to recurrence in the univariate analysis. In the multivariate analysis, low expression of CD44s in ANTE was again the sole factor related to recurrence (p=0.002, hazards ratio: 0.028). In conclusion, low expression of CD44s is related to tumour cell invasiveness and may be of clinical relevance as a prognostic factor. IntroductionCellular programs of proliferation, differentiation, senescence and apoptosis are closely linked to cell cycle regulation, and alterations of the cell cycle machinery have been described as a hallmark of cancer development (1). Molecular mechanisms controlling progression through the restriction point (R), such as the retinoblastoma protein (pRB), are of paramount importance in this context (2). Hypophosphorylated pRB inhibits S phase entry (cell arrest near R point) by forming complexes with E2F transcription factors that actively repress transcription of DNA synthesis-regulating genes (3). Upon pRB phosphorylation, pRB/E2F complexes are disrupted and E2F can activate these promoters, allowing the advance of cells to late G1 and DNA synthesis. Therefore, pRB or members of this regulatory pathway are critical molecular targets for malignant transformation, and there is growing evidence that the pRB pathway is rendered dysfunctional in oral cancer (2). Down-regulation of p16INK4a , a member of the INK family of CDK inhibitors (CDKis), has been described in oral cancer, and p16INK4a inactivation is believed to be an early event in oral carcinogenesis (4-8). Some authors reported that loss of p16INK4a is correlated with a poor prognosis in oral cancer patients (9-11), whereas others found no relationship with survival (12). In addition, some studies found loss of p21 WAF1/CIP1 , a member of CIP/KIP family of CDKis, to be a very early event in oral carcinogenesis (13)(14)(15)(16)(17). However, the prognostic significance of p21 WAF1/CIP1 expression is controversial, with several studies identifying it as a prognostic factor (18-20) and others finding no association (17,(21)(22)(23)(24).Besides alterations in their cell-cycle ...

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Correlation of Tumor Markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 With Survival and Metastasis in Laryngeal Squamous Cell Carcinoma

Cited by 131 publications

References 18 publications

Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis

Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis

Clinicopathological Significance of Expression of CD44 Variants in Head and Neck Squamous Cell Carcinoma

Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer

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