Correlation of transfusion volume to change in hematocrit

Elzik, Mark; Dirschl, Douglas R.; Dahners, Laurence E.

doi:10.1002/ajh.20517

Cited by 53 publications

(53 citation statements)

References 4 publications

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“…Standard practice for blood banking in human transfusion medicine in the United States is to achieve a HCT of 55%‐65% for each unit of pRBCs . This accomplishes standardization such that 1 unit of pRBCs in a human will increase the HCT by ∼1%/mL/kg . To our knowledge, the HCT of pRBC units from veterinary commercial blood banks has never been evaluated so based on our data and the data of others, extrapolation of these formulas to predict PCV after transfusion in cats could be inaccurate .…”

Section: Discussionmentioning

confidence: 98%

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

Sylvane

Prittie

Hohenhaus

et al. 2018

Veterinary Internal Medicne

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BackgroundNovel feline RBC antigens might contribute to decreased efficacy of RBC transfusion and increased incidence of acute transfusion reactions (ATR).ObjectivesTo examine the effect of major cross‐match in transfusion‐naïve anemic cats on the incidence of acute immunologic transfusion reaction and transfusion efficacy for up to 24 hours after transfusion.AnimalsForty‐eight client owned transfusion‐naïve anemic cats.MethodsProspective, randomized, controlled study. All transfusion‐naïve cats receiving packed red blood cells (pRBC) transfusions from January 2016 to August 2017 were eligible for inclusion. Cats in the study group received cross‐match and blood type compatible pRBCs and cats in the control group received noncross‐matched blood type compatible pRBCs. Incidence of ATR and change in PCV after transfusion was recorded.ResultsNo significant difference in incidence of transfusion reactions between cross‐matched and noncross‐matched groups (CM+ 4/24; 17%, CM– 7/24; 29%, P = .16). No significant difference between groups in mean change in PCV after transfusion scaled to dose of pRBCs administered at any time point after transfusion (immediate: CM+ 0.62 ± 0.59, CM– 0.75 ± 0.48, P = .41; 1 hour: CM+ 0.60 ± 0.66, CM– 0.74 ± 0.53, P = .43; 12 hours: CM+ 0.70 ± 0.55, CM– 0.66 ± 0.60, P = .81; 24 hours: CM+ 0.64 ± 0.71, CM– 0.55 ± 0.48, P = .70).Conclusions and Clinical ImportanceOur results do not support use of the major cross‐match test to increase efficacy of, and to decrease adverse events associated with, RBC transfusion in AB blood typed transfusion‐naïve cats.

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Section: Discussionmentioning

confidence: 98%

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

Sylvane

Prittie

Hohenhaus

et al. 2018

Veterinary Internal Medicne

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“…All studies agreed that the transfusion trigger should be higher than for healthy patients. Most studies recommended Hb 80g/l 2,5,7,8,12 35 Experts recommend transfusing to a target Hb of 70-80g/l in haemodynamically stable medical and surgical patients as well as ambulatory patients. In ACS patients with suspected ischaemia or anaemic symptoms, Hb >100g/l should be maintained.…”

Section: Discussionmentioning

confidence: 99%

An evidence-based approach to red blood cell transfusions in asymptomatically anaemic patients

Chan

2015

annals

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INTRODUCTION Surgeons and physicians encounter blood transfusions on a daily basis but a robust evidence-based strategy on indications and timing of transfusion in asymptomatic anaemic patients is yet to be determined. For judicious use of blood products, the risks inherent to packed red blood cells, the patient's co-morbidities and haemoglobin (Hb)/haematocrit levels should be considered. This review critiques and summarises the latest available evidence on the indications for transfusions in healthy and cardiac disease patients as well as the timing of transfusions relative to surgery. METHODS An electronic literature search of the MEDLINE ® , Google Scholar™ and Trip databases was conducted for articles published in English between January 2006 and January 2015. Studies discussing timing and indications of transfusion in medical and surgical patients were retrieved. Bibliographies of studies were checked for other pertinent articles that were missed by the initial search. FINDINGS Six level 1 studies (randomised controlled trials or systematic reviews) and six professional society guidelines were included in this review. In healthy patients without cardiac disease, a restrictive transfusion trigger of Hb 70-80g/l is safe and appropriate whereas in cardiac patients, the trigger is Hb 80-100g/l. The literature on timing of transfusions relative to surgery is limited. For the studies available, preoperative transfusions were associated with a decreased incidence of subsequent transfusions and timing of transfusions did not affect the rates of colorectal cancer recurrence.

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“…Weighted mean differences (WMDs) and 95 % CIs were calculated for the mean number of units transfused per patient, post-operative hemoglobin on days 5–8, drainage volume, and length of hospital stay. We regarded the volume of one unit of transfused blood as approximately 300 mL [18, 28]. When continuous data from the included studies were presented as means and 95 % confidence intervals, standard deviations were calculated by using Review Manager 5.3.5 (Cochrane).…”

Section: Methodsmentioning

confidence: 99%

The efficacy and safety of autologous blood transfusion drainage in patients undergoing total knee arthroplasty: a meta-analysis of 16 randomized controlled trials

Pan

Hong

Xie

et al. 2016

BMC Musculoskelet Disord

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BackgroundAutologous blood transfusion drainage (ABTD) has been used for many years to reduce blood loss in total knee arthroplasty (TKA). We evaluate the current evidence concerning the efficiency and safety of ABTD used in TKA compared with conventional suction drainage (CSD).MethodsWe performed a systematic literature search of the PubMed, Embase, Cochrane Library and four Chinese databases. All randomized controlled trials (RCTs) that compared the effects of ABTD versus CSD in TKA were included in the meta-analysis.ResultsSixteen RCTs involving 1534 patients who compared the effects of ABTD versus CSD were included. Five of the RCTs were performed in Asia, ten in Europe, and one in North America. Patients in the ABTD group had a lower blood transfusion rate (OR: 0.25 [0.13, 0.47]; Z = 4.27, P < 0.0001) and fewer units transfused per patient (WMD: −0.68 [−0.98, −0.39]; Z = 4. 52, P < 0.00001) than did patients in the CSD group. Wound complications, deep vein thrombosis, febrile complications, post-operative hemoglobin days 5–8, drainage volume, and length of hospital stay did not differ significantly between the two types of drainage systems.ConclusionThis meta-analysis suggests that ABTD is a safe and effective method that yields a lower blood transfusion rate and fewer units transfused per patient in TKA compared with CSD.Electronic supplementary materialThe online version of this article (doi:10.1186/s12891-016-1301-7) contains supplementary material, which is available to authorized users.

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Correlation of transfusion volume to change in hematocrit

Cited by 53 publications

References 4 publications

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

An evidence-based approach to red blood cell transfusions in asymptomatically anaemic patients

The efficacy and safety of autologous blood transfusion drainage in patients undergoing total knee arthroplasty: a meta-analysis of 16 randomized controlled trials

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