Correlation of transcutaneous bilirubin and serum bilirubin concentration in term and late preterm newborns

Gunaseelan, Sushil; Devadas, Sahana; Pai, Nandita

doi:10.4103/jcn.jcn_109_16

Cited by 11 publications

(8 citation statements)

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“…Various studies that compared the visual assessment of jaundice with TSB levels had correlation coefficients ranging from 0.36 to 0.75 and a study on transcutaneous bilirubinometry in Indian population, showed a remarkable correlation of 0.9. 4, 5,[13][14][15][16][17][18] So the accuracy of Biliscan bilirubin is better than visual assessment but not as good as the transcutaneous bilirubinometry.…”

Section: Discussionmentioning

confidence: 99%

“…Though transcutaneous bilirubinometer showed good correlation in Indian population, it is not available in all the centres, due to high cost. 4,5 It also has its limitations like, not being reliable in preterm neonates, in babies with high levels of bilirubin and post phototherapy. So there is a need for a noninvasive, real-time, inexpensive, easily available and a reliable method for estimating serum bilirubin.…”

Section: Introductionmentioning

confidence: 99%

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Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study

Lingaldinna

Konda

Bapanpally

et al. 2021

J. Nepal Paedtr. Soc.

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Introduction: Bilirubin is a frequently ordered investigation in neonatal intensive care units and out-patient practice during follow- up. The gold standard for its estimation is serum bilirubin which is invasive resulting in parenteral apprehension, pain, discomfort and iatrogenic anaemia in a neonate, while the non-invasive measurement by transcutaneous bilirubinometer is not available in all the centres because of its cost. Biliscan is a smartphone application that uses a phone’s inbuilt camera and a colour calibration card to detect neonatal jaundice. We compared bilirubin measured by Biliscan with reference to serum bilirubin among neonates admitted to a tertiary care centre. Methods: We conducted an observational study from June-2019 to September-2019 at a tertiary care centre in Hyderabad, India. Inborn neonates (greater than > 35 weeks gestational age at birth, and less than a week old) who required bilirubin estimation, underwent both invasive serum sampling and non-invasive estimation by Biliscan. Photograph of the baby’s chest was captured using the colour calibration card of the Biliscan application. Bilirubin values derived from the Biliscan application were compared to those derived from blood samples. Results: A total of 143 neonates were enrolled. The mean bilirubin value estimated by serum sampling was 11.9 g/dl against 13.1 g/dl of that derived from smartphone application. Biliscan and serum bilirubin showed moderate agreement with a correlation coefficient of 0.6. Bland- Altman plot constructed showed bias of 1.1 with the limits of agreement ranging from -3 to +5.3. Biliscan had a good sensitivity of 90% in identifying high levels of serum bilirubin (> 95th percentile on Bhutani nomogram). Conclusion: Biliscan application is a non-invasive, real-time, inexpensive and an easily available method that cannot replace serum bilirubin, however can complement and has the potential to help in screening neonates thus facilitating recognition of jaundice early and minimising the number of invasive pricks.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study

Lingaldinna

Konda

Bapanpally

et al. 2021

J. Nepal Paedtr. Soc.

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“…Transcutaneous bilirubinometer has significantly reduced the need for blood sampling in jaundiced term and latepreterm neonates compared with systematic visual assessment of bilirubin. 18,19 Studies have shown that routine use of transcutaneous bilirubinometry Mishra et.al showed that the need for blood sampling to assess hyperbilirubinemia was 34% lower in the TcB group compared with visual assessment group. 20 Kaplan et.al did a similar study using 100 paired readings and showed that 49 babies had serum bilirubin samples taken based on TcB compared with 83 serum samples taken as detected by visual assessment.…”

Section: Discussionmentioning

confidence: 99%

Kramer’s scale or transcutaneous bilirubinometry: the ideal choice of a pediatrician? can we trust our eyes?

Varughese

2019

Int J Contemp Pediatr

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Background: Neonatal hyperbilirubinemia, though benign in 80% cases, can lead to kernicterus if not diagnosed and treated early. The golden method of estimation is measuring serum bilirubin levels. Both Kramer’s scale and Transcutaneous bilirubinometer are non -invasive methods. Its high time the pediatricians choose an ideal non-invasive and reliable method to detect hyperbilirubinemia. Objective of this study is to find out which has a better correlation with serum bilirubin - transcutaneous bilirubinometer reading (TcB) or Kramer's scale.Methods: The study was conducted in a tertiary newborn center from November 2014 to June 2016. The inclusion criteria included all babies above 34 weeks gestation and exclusion criteria included babies with established direct hyperbilirubinemia, neonatal septicemia, major congenital/ gastrointestinal malformations and those on phototherapy. The sample size was 450 and the correlation was analyzed using ROC curves and plots of agreement was done using Bland Altman charts.Results: The incidence of significant Hyperbilirubinemia is 12%. Transcutaneous bilirubin level had a better correlation and prediction level compared to Kramer at both 24 hours and 48 hours. Bland Altman analysis showed that transcutaneous values were closer to the total serum bilirubin level compared to Kramer values.Conclusion: Transcutaneous bilirubinometry is a better and more ideal choice to replace serum bilirubin levels. In settings where TcB is not feasible, it’s always best to screen for jaundice using Kramer’s scale rather than estimating serum bilirubin values in all babies. In babies where TcB levels are above the cut off range, it’s better to do serum bilirubin levels.

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“…Total serum bilirubin (TSB) and transcutaneous bilirubin (TCB) methods are frequently used to assess the bilirubin level. Recent studies have reported that TSB and TCB levels are close to each other and TCB method is effective in evaluating infants at risk and would be beneficial for minimizing invasive interventions in infants (Gunaseelan, Devadas, & Pai, ).…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous bilirubin levels of newborn infants performed abdominal massage: A randomized controlled trial

Gözen

Yilmaz

Dur

et al. 2019

Specialist Pediatric Nursing

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Purpose: This study was designed as a randomized controlled trial to determine the effect of abdominal massage on bilirubin levels of newborn infants. Design and Methods:The sample group consisted of 90 newborn infants (experimental group: 44; control group: 46) who were followed in a university hospital after birth between March and August 2017. The data were collected using an Information Form, Observation Form, and Transcutaneous Bilirubin Level Meter.Bilirubin levels were measured 1 hr after the first breastfeeding in both groups. The abdominal massage was performed for 5 min in each session, was continued in three sessions per day; was completed in totally six sessions for 2 days in infants in the experimental group. The second bilirubin measurements were repeated at the 48th hour after the birth and bilirubin levels were compared in two groups. The Student t test was used to evaluate the normally distributed data and the Mann-Whitney U test was used to carry out statistics in nonnormal distribution of quantitative data. Results:The bilirubin levels of the groups (experimental group: 1.06 ± 0.92; control group: 1.01 ± 0.98) were statistically similar before abdominal massage, t(88) = 0.25, p = 0.803. The difference of the bilirubin levels was compared in the groups before and after abdominal massage. The increase of bilirubin levels in the experimental group (1.96 ± 1.69 mg/dl) was statistically significantly lower compared with the control group (2.80 ± 2.30 mg/dl), t(88) = −1.974, p = 0.048.Practice Implications: Abdominal massage is effective to reduce bilirubin levels of newborn infants.

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Correlation of transcutaneous bilirubin and serum bilirubin concentration in term and late preterm newborns

Cited by 11 publications

References 0 publications

Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study

Validity of Bilirubin Measured by Biliscan (Smartphone Application) in Neonatal Jaundice – An Observational study

Kramer’s scale or transcutaneous bilirubinometry: the ideal choice of a pediatrician? can we trust our eyes?

Transcutaneous bilirubin levels of newborn infants performed abdominal massage: A randomized controlled trial

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