Correlation of thyroid status with severity and mortality of COVID-19 patients

Abstract

Introduction: Thyroid status because of the expression of angiotensin-converting enzyme-2 (ACE2), which is a functional receptor for coronavirus disease 2019 (COVID-19) in thyroid glands, maybe affects COVID-19 patients’ outcomes. Objectives: This study aimed to evaluate the correlation of thyroid status with the severity and mortality of COVID-19 patients. Patients and Methods: In a retrospective cohort study conducted on 521 COVID-19 patients, data were collected by a demographic questionnaire and a checklist of patient outcomes (death/recovery) from the hospital information system (HIS) and analyzed by SPSS version 26 and binary logistic regression. Data about thyroid status were collected from clinical documents and laboratory test data. Results: Most patients were male (57.2%) with a mean age of 56.12 ± 17.4 years. Seventy-seven patients had a severe stage of disease, and 55 patients died. Twenty-one patients had hyperthyroidism, and 53 patients had hypothyroidism. Results showed that the correlation between hypothyroidism and hyperthyroidism with severity and mortality risk of COVID-19 patients was insignificant (P > 0.05). Conclusion: In this study, we concluded that, thyroid status is not associated with COVID-19 outcomes such as severity or mortality.

Thyroid status and severity or mortality of COVID-19

“…According to the result of this retrospective cohort study, thyroid status is not related to the severity of COVID-19 or its mortality. However, in contrast to this finding, a previous study showed the association between lower free triiodothyronine (FT3) with the severity of COVID-19 and mortality rate (1). Some mechanisms explain the changes in thyroid hormone in COVID-19 patients.…”

“…https://www.jparathyroid.com Journal of Parathyroid Disease 2022,10, e11187 of Commentary W e read the recently published article entitled "Correlation of thyroid status with severity and mortality of COVID-19 patients" with great attention (1). Although we believe the authors of this study have made a considerable contribution to this effort, we would like to add some additional comments.…”