Correlation of three-dimensional gradient echo dynamic MR imaging with CT during hepatic arteriography in patients with hypervascular hepatocellular carcinomas: Preliminary clinical experience

Yoshimitsu, Kengo; Honda, Hiroshi; Jimi, Makiko; Kuroiwa, Toshiro; Irié, Hiroyuki; Aibe, Hitoshi; Shinozaki, K.; Asayama, Yoshiki; Shimada, Mitsuo; Masuda, Kouji

doi:10.1002/1522-2586(200102)13:2<258::aid-jmri1037>3.0.co;2-b

Cited by 14 publications

(14 citation statements)

References 19 publications

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“…When considering invasiveness and patient burden of combined CTAP and CTHA, the diagnostic accuracy, sensitivity, and specificity of the combined Gd-DTPAenhanced dynamic and SPIO-enhanced MR images support its use in the preoperative evaluation of patients with HCCs and in the planning of hepatic surgery. Recently, Yoshimitsu et al [33] described that the diagnostic performance of the Gd-DTPA-enhanced 2D-FLASH sequence for the detection of hypervascular HCC can be improved by using a double dose Gd-DTPA-enhanced 3D FISP sequence. They explained that 455 Fig.…”

Section: Discussionmentioning

confidence: 99%

Preoperative detection of hepatocellular carcinoma: comparison of combined contrast-enhanced MR imaging and combined CT during arterial portography and CT hepatic arteriography

2004

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The aim of this study was to compare Gd-DTPA-enhanced dynamic MR images, superparamagnetic iron oxide (SPIO)-enhanced MR images, combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images, vs combined CT arterial portography (CTAP) and CT hepatic arteriography (CTHA), in the detection of hepatocellular carcinoma (HCC) using receiver operating characteristic (ROC) analysis. Twenty-four patients with 38 nodular HCCs (5-60 mm, mean 23.0 mm) were retrospectively analyzed. Image reviews were conducted on a liver segment-by-segment basis. A total of 192 segments, including 36 segments with 38 HCC, were reviewed independently by three radiologists. Each radiologist read four sets of images (set 1, unenhanced and Gd-DTPA-enhanced dynamic MR images; set 2, unenhanced and SPIO-enhanced MR images; set 3, combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images; set 4, combined CTAP and CTHA). To minimize any possible learning bias, the reviewing order was randomized and the reviewing procedure was performed in four sessions at 2-week intervals. The diagnostic accuracy (A(z) values) for HCCs of combined CTAP and CTHA, combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images, Gd-DTPA-enhanced dynamic MR images, and SPIO-enhanced MR images for all observers were 0.934, 0.963, 0.878, and 0.869, respectively. The diagnostic accuracy of combined CTAP and CTHA and combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images was significantly higher than Gd-DTPA-enhanced dynamic MR images or SPIO-enhanced MR images ( p<0.005). The mean specificity of combined CTAP and CTHA (93%) and combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images (95%) was significantly higher than Gd-DTPA-enhanced dynamic MR images (87%) or SPIO-enhanced MR images (88%; p<0.05). Combined Gd-DTPA-enhanced dynamic and SPIO-enhanced MR images may obviate the need for more invasive combined CTAP and CTHA for the preoperative evaluation of patients with HCC.

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Section: Discussionmentioning

confidence: 99%

Preoperative detection of hepatocellular carcinoma: comparison of combined contrast-enhanced MR imaging and combined CT during arterial portography and CT hepatic arteriography

2004

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“…MR imaging including dynamic gadolinium-chelate-enhanced imaging has been used as an important method for evaluation of hepatic lesions [1][2][3][4]. Two-or three-dimensional T1-weighted fast-gradient-echo (GRE) dynamic MRI using gadolinium-chelates has been widely used to detect hypervascular lesions, in particular hypervascular hepatocellular carcinoma (HCC) [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Two-or three-dimensional T1-weighted fast-gradient-echo (GRE) dynamic MRI using gadolinium-chelates has been widely used to detect hypervascular lesions, in particular hypervascular hepatocellular carcinoma (HCC) [1][2][3][4]. Some investigators have described the use of high-spatial-resolution dynamic MR imaging (HR-MRI) during a single breath-hold for the detection of HCC, which has become feasible with the development of MR pulse sequences and phase array multicoils [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Prospective comparison of high- and low-spatial-resolution dynamic MR imaging with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinoma

et al. 2008

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The purpose of this study was to prospectively evaluate the efficacy of high-spatial-resolution dynamic MRI using sensitivity encoding (SENSE) in detection of hypervascular hepatocellular carcinoma (HCC). Thirty-five patients were included in this prospectively planned study, and 25 patients with 31 HCCs were assigned into three groups and underwent the following sequences: group A (n=11): three-dimensional fast-gradient-echo (3D-FGE) high-spatial-resolution dynamic MRI (HR-MRI) with SENSE; group B (n=10): 3D-FGE low-spatial-resolution dynamic MRI (LR-MRI) with SENSE; and group C (n=14): 3D-FGE/LR-MRI without SENSE. For the quantitative analysis, the lesion-to-liver contrast-to-noise ratio (CNR) between the liver and HCCs was measured. For the qualitative analysis, overall image quality for each group was evaluated with a five-point scale analysis. The sensitivities for detection of HCCs were evaluated. The overall image quality in group A was significantly greater than both groups B and C (P<0.01). The sensitivity of lesion detection on HAP was not significantly higher in group A (100%) than group C (69.2%; P>0.05). In our pilot study on a small number of patients, image quality in HR-MRI with SENSE was superior to LR-MRI. A high detection rate was seen with HR-MRI with SENSE in the patients with hypervascular HCCs.

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“…Two-or three-dimensional (3D) T1-weighted fast gradient-echo sequence dynamic MRI has been widely used to detect these hypervascular lesions [1][2][3][4]. A parallel imaging technique has become available for many of the commercial magnetic resonance (MR) scanners [5][6][7][8], through which one is able to reduce the scan time, thereby increasing the temporal resolution of MRI, and a recent report has shown that double arterial phase dynamic MRI, using extracellular contrast agent at a single breath-hold with sensitivity encoding (SENSE), is useful in improving the detectability of hypervascular HCCs [9].…”

Section: Introductionmentioning

confidence: 99%

Higher lesion conspicuity for SENSE dynamic MRI in detecting hypervascular hepatocellular carcinoma: analysis through the measurements of liver SNR and lesion–liver CNR comparison with conventional dynamic MRI

et al. 2005

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The aim of our study was to compare the signal-to-noise ratio (SNR) of liver parenchyma and the contrast-to-noise ratio (CNR) of hypervascular hepatocellular carcinoma (HCC) between conventional and SENSE dynamic MRI. Thirty-one consecutive patients who were strongly suspected of having HCC were enrolled in our study. The subjects consisted of 20 men and 11 women aged 52 years to 79 years (mean 66.8 years). Dynamic MRI was performed for each patient, with SENSE (SENSE MRI) and without SENSE (conventional MRI) on separate days. For the quantitative analysis, the liver SNR and the lesion-liver CNR of 25 hypervascular HCCs detected on both conventional and SENSE dynamic MRI were measured. The liver SNR of the arterial phase and the portal venous phase was 84.1+/-24.7 and 104.7+/-34.3, respectively, in conventional MRI, while it was 62.9+/-19.5 and 44.5+/-18.2, respectively, in SENSE MRI. SENSE MRI showed a statistically significantly lower SNR than conventional MRI (P<0.01). The lesion-liver CNR was 26.3+/-15.9 in conventional MRI and 39.0+/-19.6 in SENSE MRI. The lesion-liver CNR in SENSE MRI was significantly higher than in conventional MRI (P<0.01). The SNR in SENSE MRI is significantly lower than in conventional MRI, although the lesion CNR is significantly higher than in conventional MRI.

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Correlation of three-dimensional gradient echo dynamic MR imaging with CT during hepatic arteriography in patients with hypervascular hepatocellular carcinomas: Preliminary clinical experience

Cited by 14 publications

References 19 publications

Preoperative detection of hepatocellular carcinoma: comparison of combined contrast-enhanced MR imaging and combined CT during arterial portography and CT hepatic arteriography

Preoperative detection of hepatocellular carcinoma: comparison of combined contrast-enhanced MR imaging and combined CT during arterial portography and CT hepatic arteriography

Prospective comparison of high- and low-spatial-resolution dynamic MR imaging with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinoma

Higher lesion conspicuity for SENSE dynamic MRI in detecting hypervascular hepatocellular carcinoma: analysis through the measurements of liver SNR and lesion–liver CNR comparison with conventional dynamic MRI

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