Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with rett syndrome

Brašić, James Robert; Bibat, Genila; Kumar, Anil; Zhou, Yun; Hilton, John; Yablonski, Maya; Doğan, Ahmet; Guevara, Maria; Stephane, Massoud; Johnston, Michael V.; Wong, Dean F.; Naidu, Sakkubai

doi:10.1002/syn.21515

Cited by 20 publications

(16 citation statements)

References 67 publications

(87 reference statements)

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“…The two scans were separated by 75 min. The head was stabilized for both PET and MRI by an individualized thermoplastic mask and Velcro straps (Brašić et al, 2012). A laser light in the PET scanner was used to line up an axial line on the mask and the scanner bed and participant head tilt were monitored by the PET technologist for the entire scan.…”

Section: Methodsmentioning

confidence: 99%

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

et al. 2017

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The attention system is shaped by reward history, such that learned reward cues involuntarily draw attention. Recent research has begun to uncover the neural mechanisms by which learned reward cues compete for attention, implicating dopamine (DA) signaling within the dorsal striatum. How these elevated priority signals develop in the brain during the course of learning is less well understood, as is the relationship between value-based attention and the experience of reward during learning. We hypothesized that the magnitude of the striatal DA response to reward during learning contributes to the development of a learned attentional bias towards the cue that predicted it, and examined this hypothesis using positron emission tomography with [11C]raclopride. We measured changes in dopamine release for rewarded versus unrewarded visual search for color-defined targets as indicated by the density and distribution of the available D2/D3 receptors. We then tested for correlations of individual differences in this measure of reward-related DA release to individual differences in the degree to which previously reward-associated but currently task-irrelevant stimuli impair performance in an attention task (i.e., value-driven attentional bias), revealing a significant relationship in the right anterior caudate. The degree to which reward-related DA release was right hemisphere lateralized was also predictive of later attentional bias. Our findings provide support for the hypothesis that value-driven attentional bias can be predicted from reward-related DA release during learning.

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Section: Methodsmentioning

confidence: 99%

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

et al. 2017

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“…There is also evidence for striatal cholinergic dysfunction in RTT (Wenk & Mobley, 1996). For example, striatal vesicular acetylcholine transporter densities are reduced in women with RTT, and their clinical abilities are correlated with these levels (Brasic et al, 2012). …”

Section: Diseases and Links To Striatal Dysfunctionmentioning

confidence: 99%

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

Pappas

Leventhal

Albin

et al. 2014

Current Topics in Developmental Biology

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This chapter focuses on neurodevelopmental diseases that are tightly linked to abnormal function of the striatum and connected structures. We begin with an overview of three representative diseases in which striatal dysfunction plays a key role—Tourette syndrome and obsessive-compulsive disorder, Rett's syndrome, and primary dystonia. These diseases highlight distinct etiologies that disrupt striatal integrity and function during development, and showcase the varied clinical manifestations of striatal dysfunction. We then review striatal organization and function, including evidence for striatal roles in online motor control/action selection, reinforcement learning, habit formation, and action sequencing. A key barrier to progress has been the relative lack of animal models of these diseases, though recently there has been considerable progress. We review these efforts, including their relative merits providing insight into disease pathogenesis, disease symptomatology, and basal ganglia function.

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“…Various factors maybe causing this. For instance, it might relate to some extent to smoking-induced changes in nicotinic receptor number and sensitivity (Kadir et al, 2006; Brasic et al, 2012), or alternatively, disease-specific developmental disturbances in receptor expression or aberrant development of circuitry may underlie this.…”

Section: Beneficial Effects Of Nicotine-like Substancesmentioning

confidence: 99%

The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations

Counotte¹,

Smit²,

Spijker³

2012

Front. Pharmacol.

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Nicotine has remarkably diverse effects on the brain. Being the main active compound in tobacco, nicotine can aversively affect brain development. However, it has the ability to act positively by restoring attentional capabilities in smokers. Here, we focus on nicotine exposure during the prenatal and adolescent developmental periods and specifically, we will review the long-lasting effects of nicotine on attention, both in humans and animal models. We discuss the reciprocal relation of the beneficial effects of nicotine, improving attention in smokers and in patients with neuropsychiatric diseases, such as schizophrenia and attention deficit/hyperactivity disorder, vs. nicotine-related attention deficits already caused during adolescence. Given the need for research on the mechanisms of nicotine’s cognitive actions, we discuss some of the recent work performed in animals.

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Correlation of the vesicular acetylcholine transporter densities in the striata to the clinical abilities of women with rett syndrome

Cited by 20 publications

References 67 publications

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Linking dopaminergic reward signals to the development of attentional bias: A positron emission tomographic study

Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits

The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations

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