Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease

Piplani, Shobhit; Alemao, Nadezdha Niyarah; Prabhu, Madhav; Ambar, Sameer; Chugh, Yashasvi; Chugh, Sanjay K.

doi:10.1016/j.ihj.2018.09.007

Cited by 13 publications

(8 citation statements)

References 25 publications

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“…Although a number of studies have shown an association between telomere length and diabetes [23,24,25,26,27,28,29,30,31] in some, this association was weak [28], cell type dependent [24] or associated with heart disease [30,31]. Sampson et al measured the telomere length of peripheral blood monocytes and T-cells in Type 2 diabetes and normal controls.…”

Section: Discussionmentioning

confidence: 99%

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans

Weale

Davison

Hon

et al. 2019

Cells

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Telomeres are DNA-tandem repeats situated at the ends of chromosomes and are responsible for genome stabilization. They are eroded by increased cell division, age and oxidative stress with shortened leucocyte telomeres (LTL) being associated with inflammatory disorders, including Type II diabetes. We assessed LTL in 205 participants across glucose tolerance groups at baseline and after three years in the mixed ancestry population of South Africa which have been shown to have high rates of obesity and T2DM. Baseline and follow-up data included glucose tolerance status, anthropometric measurements, lipids, insulin, γ-glutamyl transferase (GGT), cotinine, and HbA1c. Telomere length was measured using the absolute telomere q-PCR method performed on a Bio-Rad MiniOpticon Detector. No significant difference was detected in LTL across glucose tolerance groups at both time points, including in subjects who showed a deterioration of their glucose tolerance status. There was, however, a significant negative correlation between LTL and age which was more pronounced in diabetes (r = −0.18, p = 0.04) and with GGT (r = −0.16, p = 0.027). This longitudinal study has demonstrated that LTL shortening is not evident within three years, nor is it associated with glycaemia. Further studies in a larger sample and over a longer time period is required to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans

Weale

Davison

Hon

et al. 2019

Cells

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“…In T2DM patients, the antiinflammatory adipokine adiponectin was found to positively correlate with TL, therefore adiponectin could potentially slow down aging 49 . Patients with ischaemic heart disease show a substantial correlation between telomere shortening and T2DM 50 . Age, known diabetes duration, blood pressure, glucose management, and baseline lipid levels were all linked with TL 51 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Dirican

Kaya

2023

Cukurova Medical Journal

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Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects a significant proportion of the global population. This study aimed to evaluate the effect of NFKB1 -94 ATTG ins/del polymorphisms on the expression of apoptosis genes and telomere length (TL) in patients with T2DM compared with healthy individuals. Materials and Methods: Sixty-nine T2DM patients and sixty healthy people were enrolled in the study. DNA and RNA were isolated from the blood samples. NFKB1 genotypes were identified by Sanger sequencing. For TL analyses and to investigate the expression of the caspase-3, caspase-9, bax, and bcl2 genes, RT-PCR was utilized. Results: There was a significant difference between the NFKB1 -94 ins/del genotype patients and the control group (OR:0.4792 (0.2345-1.011)). However, the distribution of other genotype/alleles (ins/ins and del/del) showed no difference between T2DM and control groups. The allelic frequency of NFKB1 -94 ins/del was 0.455/0.235 for the T2DM group and 0.435/0.165 for the control group. An increase in the mRNA expression of caspase-3, caspase-9 and Bax genes was observed in the T2DM group compared with the healthy group, while a decrease in the Bcl2 gene was found in the T2DM group. TL in T2DM patients was shorter than in healthy individuals. Conclusion: NFKB1 -94 ins/del polymorphisms show significant differences in T2DM patients. We observed that apoptosis was activated and TL was shortened in patients with T2DM. However, no relationship between NFKB1 polymorphisms and apoptosis and TL could not be determined.

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“…Firstly, age has been shown to negatively affect TL, with older age linked to shorter telomeres (12). Secondly, smoking has also been shown to negatively affect TL and likewise, so have the comorbidities; type 2 diabetes and obesity (30)(31)(32). Thirdly, research has also shown a link between short telomeres and hypertension, chronic obstructive pulmonary disorder and coronary heart diseasethe other comorbidities included within M4 (33-35).…”

Section: Discussionmentioning

confidence: 99%

Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist

Reeves

Kooner

Zhang

2022

Front. Public Health

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BackgroundWhile increased age is an established risk factor for COVID-19, there is great heterogeneity in outcomes within age groups. This is because chronological age does not reflect health, unlike biological age. We intend to investigate the association between accelerated ageing and COVID-19 outcomes through the lens of three measures, namely phenotypic age acceleration (PhenoAgeAccel), telomere length (Adjusted T/S Ratio) and facial ageing, and to examine whether there are differences across ethnic groups.MethodsTaking participants from the UK Biobank, we associated accelerated ageing with severe COVID-19 outcomes, defined as COVID-related hospitalisation or death. Separate logistic regressions models were created for age and the three accelerated ageing-related variables, adjusting for a variety of covariates in each model. Multivariable logistic regression models were also created within White, Black, Asian and Other ethnic groups to assess for potential differing associations. Forward likelihood ratio logistic regression models were created to evaluate importance of the variables and to assess for patterns of association across the total population and ethnic groups.ResultsAfter adjusting for all covariates, the odds ratio (OR) and 95% confidence interval (95% CI) of COVID-19 severe outcomes for age was 1.080 (1.074–1.086). After further adjusting age for the accelerated ageing variables, the ORs were 1.029 (1.020–1.039) for PhenoAgeAccel and 0.847 (0.772–0.929) for Facial Ageing's “Younger Than You Are” while Adjusted T/S ratio and “Older Than You Are” were statistically insignificant. The OR for age remained similar across ethnic groups. Both PhenoAgeAccel and younger facial ages in the White population and PhenoAgeAccel in the Black population had ORs of 1.031 (1.021–1.042), 0.853 (0.774–0.939), and 1.049 (1.001–1.100), respectively. Both Adjusted T/S Ratio and older facial ages showed statistical insignificance in all ethnicities. In forward logistic regression, age and PhenoAgeAccel were the age-related variables selected most frequently in all models.InterpretationAccelerated ageing is associated with increased COVID-19 severity. The mechanisms at work here are likely immunosenescence and inflamaging. This association indicates that anti-ageing treatment may improve COVID-19 outcome. The results within ethnic groups and that of telomere length were inconclusive, but point to a need for future, more focused research on the topic.

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Correlation of the telomere length with type 2 diabetes mellitus in patients with ischemic heart disease

Cited by 13 publications

References 25 publications

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Accelerated ageing is associated with increased COVID-19 severity and differences across ethnic groups may exist

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