Correlation of the tei index with invasive measurements of ventricular function in a porcine model

LaCorte, Jared C; Cabreriza, Santos E.; Rabkin, David G.; Printz, Beth F.; Çoku, Lindita; Weinberg, Alan; Gersony, Welton M.; Spotnitz, Henry M.

doi:10.1016/s0894-7317(03)00110-x

Cited by 99 publications

(85 citation statements)

References 14 publications

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“…17 MPI was also used to assess the cardiac systolic function. 18,19 EF showed no difference between low-calcium and standard-calcium groups, which indicated systolic function did not altered according to dialysate calcium concentration in this study. In that case, increment in MPI was admitted as the index indicating the impairment of LV diastolic function in PD patients.…”

Section: Discussionmentioning

confidence: 49%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV diastolic function has not been clear. The aim of this study was to investigate the influence of low calcium dialysate on cardiac function in peritoneal dialysis (PD) patients. A total of 60 PD patients were enrolled in this study, with a calcium content of the PD solution of 1.25 mmol/L in 30 patients (low-calcium group) and 1.75 mmol/L in 30 patients (standard-calcium group). Standard M-mode and two-dimensional ultrasound measurements were applied to detect the cardiac function. After 12-month follow-up, we found no significant difference in blood pressure, calcium, phosphorus, parathyroid hormone (PTH), etc., between the two groups. Residual renal function (RRF), which is associated with LV cardiac function, was significantly decreased in the standard-calcium group compared with the low-calcium group (5.64 ± 3.23 vs. 9.38 ± 3.17, p ¼ .001). Compared with the low-calcium group, E max (peak early diastolic velocity) and A max (peak late diastolic velocity) were significantly decreased (p < .05), whereas myocardial performance index (MPI) was obviously increased in standard-calcium group (9.69 ± 2.71 vs. 7.75 ± 0.93, p < .05). In conclusion, our data suggest that low calcium dialysate treatment is significantly associated with better LV diastolic function. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 49%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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“…Moreover, the Tei index (TEI), an index of myocardial performance useful in estimating ventricle function, demonstrated to correlation with indicators of diastolic function, including the diastolic peak (-dP/ dt) and tau in people with ischemic heart disease (Tei et al 1997). Also, in a porcine model, this index showed a direct correlation with the ventricular stiffness constant, and it was inversely related to the ejection fraction, thereby supporting its clinical use not only as an indicator of diastolic performance, but as a measure of global ventricular function (Lacorte et al 2003). TEI is defined as (Isovolumic contraction time + Isovolumic relaxation time)/Left-ventricular ejection time, as reported elsewhere (Tei 1995.…”

Section: Introductionmentioning

confidence: 77%

Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy

et al. 2014

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RESUMENEl desarrollo de una cardiomiopatía dosis dependiente es la principal limitación para el uso de doxorrubicina en protocolos de quimioterapia tanto en seres humanos como en animales. En estos casos, la función global del miocardio puede ser cedida, teniendo como resultado signos atribuibles a la insuficiencia cardíaca congestiva. En este estudio, nosotros investigamos la capacidad del índice de desempeño miocárdico de Tei para identificar disfunción de miocardio en perros sanos tratados con doxorrubicina a una dosis cumulativa de 210 mg/m 2 en un periodo de 147 días, comparándolo con otros indicadores ecográficos estándar de función sistólica y diastólica. Nuestros resultados indicaron que el índice de Tei, el tiempo de relajación isovolumétrica, el período de pre-eyección, y la relación período de pre-eyección/tiempo de eyección ventricular izquierda pudieron identificar los efectos cardiotóxicos de doxorrubicina en la función cardíaca cuando sólo 60 mg/m 2 habían sido administrados, mientras los parámetros estándar sistólicos y diastólicos, incluso el diámetro sistólico del ventrículo izquierdo, la fracción de eyección y la fracción de acortamiento, necesitaron por lo menos 120 mg/mg 2 para empeorar. Se concluye que la terapia prolongada con antraciclinas perjudica las funciones sistólica y diastólica, que pueden ser documentadas antes adicionándose el índice de Tei a la evaluación ecográfica estándar en animales que reciben doxorrubicina.Palabras clave: cardiotoxicidad, antraciclinas, disfunción cardiaca, quimioterapia. SUMMARYThe development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated the ability of the Tei index of myocardial performance to identify myocardial dysfunction in healthy dogs receiving doxorubicin to a cumulative dose of 210 mg/m 2 over 147 days, comparing it with other standard echocardiographic indicators of systolic and diastolic function. Our results indicated that the Tei index, the isovolumic relaxation time, pre-ejection period and the pre-ejection period-to-left ventricular ejection time ratio were able to identify the cardiotoxic effects of doxorubicin on cardiac function when only 60 mg/m 2 had been administered, while the standard systolic and diastolic parameters, including left ventricular diameter at systole, ejection fraction, and fractional shortening needed at least 120 mg/mg 2 to deteriorate. We concluded that prolonged anthracycline therapy compromises both systolic and diastolic functions, which may be documented earlier by including the Tei index evaluation to the standard echocardiographic assessment of animals receiving doxorubicin.

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“…Likewise, several investigators have demonstrated its good correlation with invasive measurements of cardiac function, including an inverse relationship with cardiac output, as well as direct correlation with systolic peak dP/dT, diastolic peak dP/ dT, and ventricular stiffness (Tei et al 1997, Lacorte et al 2003. Since it was shown to be relatively load-independent, it could be especially useful to evaluate remodeled hearts, in which the altered preload and afterload conditions are likely to interfere with the standard echo parameters used to assess cardiac function, including ejection and shortening fractions.…”

Section: Discussionmentioning

confidence: 96%

Tei index of myocardial performance in conscious healthy Beagles

et al. 2016

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ABSTRACT. The Tei index of myocardial performance is a noninvasive echocardiographic parameter that combines systolic and diastolic time intervals to assess global cardiac performance. It was demonstrated to be a reliable indicator of myocardial dysfunction in dogs with varying clinical conditions. Because only a few studies focused on the measurement of the index in healthy dogs, this cross-sectional study was conceived to investigate how it performs in a large population of clinically healthy Beagle dogs. Our results showed no correlation between the index and body weight, heart rate, and several standard echocardiographic measures which are estimates of preload and afterload. There was no difference between de index calculated for males or females. Also, results indicated strong intra-observer and inter-observer correlations. In conclusion, the Tei index was shown to perform independently of loading conditions, besides being a straightforward and easily reproducible parameter.Key words: echocardiography, cardiac function, Doppler, dog. RESUMEN.El índice de rendimiento miocárdico es un parámetro ecocardiográfico no invasivo que combina intérvalos de tiempo sistólico y diastólico para evaluar el rendimiento cardiaco total. Se ha demostrado que es un indicador fiable de disfunción miocárdica en perros con diferentes condiciones clínicas. Debido a que pocos estudios se centraron en la medición de este índice en perros sanos, este estudio transversal fue concebido para investigar este rendimiento en una gran población de perros Beagle clínicamente sanos. Nuestros resultados no muestran correlación entre el índice y el peso corporal, la frecuencia cardiaca, y varias medidas ecocardiográficas que son estimaciones estándar de precarga y poscarga. No hubo diferencia entre machos y hembras para el índice calculado. Además, los resultados indicaron notorias correlaciones intraobservador e interobservador. En conclusión, el índice de Tei se mostró como un parámetro independiente de las condiciones de la carga, que además de ser fácil de calcular también es un parámetro de fácil reproducción.

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Correlation of the tei index with invasive measurements of ventricular function in a porcine model

Cited by 99 publications

References 14 publications

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy

Tei index of myocardial performance in conscious healthy Beagles

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