Correlation of the SUVmax of FDG-PET and ADC values of diffusion-weighted MR imaging with pathologic prognostic factors in breast carcinoma

Radiogenomic Analysis of Oncological Data: A Technical Survey

“…The election imaging method for Breast Cancer (BC) was MRI (78%) [91,97,103,104,105,106,107,108,109,110,111,112,113,114,115,116,120,121]. About 78% of the BC published papers were correlation studies [91,103,104,105,106,107,108,109,110,111,112,114,117,118,119,120,122,123] and the most used genomic data was IHC results (65%) [103,104,105,107,108,111,112,113,114,115,116,117,118,119,120].…”

“…About 78% of the BC published papers were correlation studies [91,103,104,105,106,107,108,109,110,111,112,114,117,118,119,120,122,123] and the most used genomic data was IHC results (65%) [103,104,105,107,108,111,112,113,114,115,116,117,118,119,120]. However, although IHC is routinely applied in the clinical practice, it is not an “omic” approach, remaining the elective method to determine the BC molecular subtypes (Luminal A, Luminal B, basal-like, and triple-negative (TNBC)), useful for therapeutic indications [154].…”

“…Only three studies correlated IHC results and PET/CT imaging features, reporting an association between FDG uptake and Ki67 [117,119], FDG uptake and tumour size in TNBC [117] and higher SUVmax with triple-negative and HER2-positive tumours [118]. Three works focused on prediction studies combining IHC with MRI [113,115,116] or with PET [116]. …”

Breast PET/MR Imaging

“…48,49 ADC shows fewer relationships, but has been correlated with PR+, 50 ER+, 51 and HER2− cancers, 50,51 and with tumor size, Ki67 expression, histologic subtype, the presence of axillary metastases, and TNM staging. 48 Karan and colleagues, 49 however, saw no correlations between ADC median and many of these metrics. Low ADC and high SUVmax have been associated with vascular invasion.…”

“…49–51 SUVmax has been shown to positively correlate with many prognostic factors including tumor size, 48–51 nuclear/histologic grade, 48–51 higher Ki67, 40,48,52 TNM staging, 48 TNBC tumor type, 40,51 lymph node positivity, 48,49,51 ER−, 48,49,51 PR−, 48,51 and HER2+ status. 48,49 ADC shows fewer relationships, but has been correlated with PR+, 50 ER+, 51 and HER2− cancers, 50,51 and with tumor size, Ki67 expression, histologic subtype, the presence of axillary metastases, and TNM staging. 48 Karan and colleagues, 49 however, saw no correlations between ADC median and many of these metrics.…”