Correlation of the Renal Cortex Volume With the Glomerular Filtration Rate in Live Donors for Renal Transplantation

García-Covarrubias, Luis; Valdez, Dan; Bermudez, L.A.; Avelar, Francisco; Villanueva, Rosa; Ortuño, D.; Hernández, J Castillo; García, Ángel Sánchez; Castro, I.

doi:10.1016/j.transproceed.2017.12.045

Cited by 4 publications

(4 citation statements)

References 21 publications

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“…Recent reports suggest that contrast-enhanced CT scans with determination of cortex volume could substitute measurement of skGFR. 35,37,38 However, our observations emphasize the importance of determining both split renal function and cortex volume as part of the LKD examination program.…”

Section: Renal Outcome In Lkdsmentioning

confidence: 71%

Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology

et al. 2022

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Background. Living kidney donors (LKDs) are at increased risk of chronic kidney disease, whereas transplant recipients experience progressive reduction of graft function. We examined the predictive value of quantitative stereology on renal function in LKDs and recipients of living donor kidneys, based on perioperative biopsies from the donated kidney. Methods. Cortex volume of both donor kidneys was determined by contrast-enhanced computed tomography and single-kidney glomerular filtration rate (GFR) by 51chrome-EDTA clearance together with renography. Glomerular density was used to estimate total glomeruli number in addition to glomerular volume, glomerular sclerosis, kidney fibrosis, and arteriole dimensions. GFR measurements were repeated 1 y after transplantation in both LKDs and recipients. Associations between GFR at follow-up and cortex volume and histomorphometric parameters after adjustment of age, gender, body mass index, smoking status, 24-h blood pressure, and single-kidney GFR were examined. Results. We included 49 LKDs (age, 51 ± 12 y) and 51 recipients (age, 44 ± 13 y). At follow-up, GFR was 71 ± 16 mL/min in LKDs and 61 ± 18 mL/min in recipients with hyperfiltration being more prominent in LKDs (30.4%) as compared to recipients (16.4%; P < 0.05). One-year GFR in donors correlated to cortex volume (P < 0.001) but not to any histological parameters, whereas GFR in recipients correlated to the amount of interstitial fibrosis (P < 0.01) but not to other histological parameters or cortex volume. Conclusions. Kidney cortex volume, but not renal histology parameters, predicts 1-y renal outcome in LKDs. In contrast, the amount of interstitial fibrosis, but not cortex volume, predicts 1-y graft function in recipients.

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Section: Renal Outcome In Lkdsmentioning

confidence: 71%

Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology

et al. 2022

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“…Prior work has been limited in that the majority of these studies have only assessed whether CVR is associated with postdonation eGFR, whereas several have compared it with SSR. 5-10 We show that not only is CVR an alternative to SSR but furthermore, that the combination of eGFR and CVR in the preoperative period is superior to predictive models using predonation mGFR.…”

Section: Discussionmentioning

confidence: 82%

“…32 Our work expands on prior studies in several ways. [5][6][7][8][9][10] Most notably, our analysis provides an assessment of not only CVR and its relationship with postdonation eGFR but also several other important relationships including predonation mGFR and SSR and each of the combinations of these preoperative parameters commonly used for postdonation eGFR prediction. Prior work has been limited in that the majority of these studies have only assessed whether CVR is associated with postdonation eGFR, whereas several have compared it with SSR.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, our patients undergo predonation creatinine-based estimated glomerular filtration rate (eGFR) calculation and computerized tomography (CT) scanning, the latter of which can undergo further processing to obtain the cortical volume ratio (CVR) of each kidney. [5][6][7][8][9][10] Essentially, these nuclear medicine and nonnuclear medicine studies ascertain reciprocal values: the mGFR obtained from 125 I-iothalamate clearance is analogous to the eGFR from creatinine-based calculation and the split scan ratio (SSR) obtained from the 99m Tc-DTPA split scan is analogous to the CVR from postprocessing of CT images. Given the costs of these nuclear medicine studies and potential availability of eGFR and CVR results for all living kidney donor candidates at our institution, a critical assessment of their association with postdonation kidney function is warranted and may inform future policy considerations for utilization during potential living kidney donor evaluation.…”

Section: Introductionmentioning

confidence: 99%

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CT-measured Cortical Volume Ratio Is an Accurate Alternative to Nuclear Medicine Split Scan Ratio Among Living Kidney Donors

et al. 2021

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Background. The 125I-iothalamate clearance and 99mTc diethylenetriamine-pentaacetic acid (99mTc-DTPA) split scan nuclear medicine studies are used among living kidney donor candidates to determine measured glomerular filtration rate (mGFR) and split scan ratio (SSR). The computerized tomography–derived cortical volume ratio (CVR) is a novel measurement of split kidney function and can be combined with predonation estimated GFR (eGFR) or mGFR to predict postdonation kidney function. Whether predonation SSR predicts postdonation kidney function better than predonation CVR and whether predonation mGFR provides additional information beyond predonation eGFR are unknown. Methods. We performed a single-center retrospective analysis of 204 patients who underwent kidney donation between June 2015 and March 2019. The primary outcome was 1-y postdonation eGFR. Model bases were created from a measure of predonation kidney function (mGFR or eGFR) multiplied by the proportion that each nondonated kidney contributed to predonation kidney function (SSR or CVR). Multivariable elastic net regression with 1000 repetitions was used to determine the mean and 95% confidence interval of R 2, root mean square error (RMSE), and proportion overprediction ≥15 mL/min/1.73 m2 between models. Results. In validation cohorts, eGFR-CVR models performed best (R 2, 0.547; RMSE, 9.2 mL/min/1.73 m2, proportion overprediction 3.1%), whereas mGFR-SSR models performed worst (R 2, 0.360; RMSE, 10.9 mL/min/1.73 m2, proportion overprediction 7.2%) (P < 0.001 for all comparisons). Conclusions. These findings suggest that predonation CVR may serve as an acceptable alternative to SSR during donor evaluation and furthermore, that a model based on CVR and predonation eGFR may be superior to other methods.

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Association of Sleep Lack with Blood Pressure and Kidney Functions among Young People in Erbil City

et al. 2019

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Short sleep duration could be deemed a risk factor in occurring cardiovascular system and renal physiological malfunctions. Hence, the present study carried out from December 2018 to January 2019, intended to investigate the association between sleep lack with a circulation system and kidney functions among both genders of students (12 females plus 25 males) who have 18–23 years age and attending Salahaddin University-Erbil. The trial included a sleep lack group (sleep duration <6 h). The second group represented as a control (sleep duration >6 h). Blood pressure (BP) (systolic BP [SBP], diastolic BP [DBP], and mean arterial pressure [MAP]) and weights were estimated for both groups. Blood samples were taken to determine serum creatinine utilizing fully automatically biochemical analyzer and also glomerular filtration rate (GFR) was estimated and calculated according to the Cockcroft-Gault equation. The procured results revealed that SBP was elevated in all participants in the sleep lack group as compared to the control group, while no significant change in DBP was perceived. Furthermore, MAP was increased in all volunteers in the sleep-deprived group. The results also demonstrated that the serum creatinine was raised and concomitantly estimated GFR values were elevated in sleep-deprived group as compared to the control group. Pursuant to the receiver operating characteristic curve, serum creatinine can be a risk factor for sleep lack as well. In the light of the current study, it has been concluded that the sleep lack has a role in elevating SBP but not DBP and it was related with hypertension. Furthermore, the results indicated that serum creatinine was significantly increased in students with sleep lack.

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Correlation of the Renal Cortex Volume With the Glomerular Filtration Rate in Live Donors for Renal Transplantation

Cited by 4 publications

References 21 publications

Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology

Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology

CT-measured Cortical Volume Ratio Is an Accurate Alternative to Nuclear Medicine Split Scan Ratio Among Living Kidney Donors

Association of Sleep Lack with Blood Pressure and Kidney Functions among Young People in Erbil City

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