Correlation of the formation constant of ferrocene–cyclodextrin complexes with dielectric properties of the aqueous DMSO solution

Kolivoška, Viliam; Gál, Miroslav; Hromadová, Magdaléna; Valášek, Michal; Pospı́šil, Lubomı́r

doi:10.1016/j.jorganchem.2011.01.007

Cited by 14 publications

(7 citation statements)

References 30 publications

(39 reference statements)

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“…The two reduction peaks may be attributed to the two carbonyl groups present in CDF molecule. The electrochemical behavior of CDFCD was found to be similar to CDF with significant shifting of peak positions towards positive potentials and decreased peak current (33,34). CDFCD was found to exhibit reduction peaks at −1103 mV and −1380 mV, while oxidation peak was seen at 294 mV.…”

Section: Resultsmentioning

confidence: 93%

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Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer

Dandawate¹,

Vyas²,

Ahmad

et al. 2012

Pharm Res

118

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Purpose Several formulations have been proposed to improve the systemic delivery of novel cancer therapeutic compounds, including cyclodextrin derivatives. We aimed to synthesize and characterize of CDF-β-cyclodextrin inclusion complex (1:2) (CDFCD). Methods The compound was characterized by Fourier transform infrared, differential scanning calorimetry, powder X-ray diffraction studies, H1 & C13 NMR studies and scanning electron microscopic analysis. Its activity was tested against multiple cancer cell lines, and in vivo bioavailability was checked. Results CDF-β-cyclodextrin was found to lower IC50 value by half when tested against multiple cancer cell lines. It preferentially accumulated in the pancreas, where levels of CDF-β-cyclodextrin in mice were 10 times higher than in serum, following intravenous administration of an aqueous CDF-β-cyclodextrin preparation. Conclusions Novel curcumin analog CDF preferentially accumulates in the pancreas, leading to its potent anticancer activity against pancreatic cancer cells. Synthesis of such CDF-β-cyclodextrin self-assembly is an effective strategy to enhance its bioavailability and tissue distribution, warranting further evaluation for CDF delivery in clinical settings for treatment of human malignancies.

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Section: Resultsmentioning

confidence: 93%

“…Cyclic voltammetry (CV) has been used for studying the interaction between cyclodextrin and drug molecules (32,33). In present investigation we have also incorporated CV studies for analyzing inclusion complex of CDF with β-CD (Supplementary Material Fig.…”

Section: Resultsmentioning

confidence: 99%

Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer

Dandawate¹,

Vyas²,

Ahmad

et al. 2012

Pharm Res

118

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“…It is known that b-CD could interact with ferrocene and its derivatives to form stable inclusion complexes in various DMSO-water mixtures. 22 Here, in order to make sure that both PEI-Fc and Em-bCD exhibited good solubility, the volume fraction of DMSO should be beyond 0.3. The solutions of PEI-Fc and Em-bCD were both transparent, while a brown-red precipitate appeared gradually aer the two solutions were mixed, indicating the formation of supramolecular aggregates.…”

Section: Introductionmentioning

confidence: 99%

A reversible functional supramolecular material formed by host–guest inclusion

et al. 2014

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Humanity has an urgent need to develop more degradable materials for solving environmental pollution. In this study, through host-guest interactions between fatty acids-modified b-cyclodextrin (Em-bCD) and polyethylenimine (PEI) oligomer-grafted ferrocene (PEI-Fc), we designed and prepared a supramolecular polymer (PEI-Fc/Em-bCD complex), which showed polymeric properties and was able to be used as a cushioning material due to its good compressibility. Compared with conventional polymers, a remarkable advantage of the PEI-Fc/Em-bCD complex is that it can be dismantled into small molecules and rebuilt easily by controlling the dissociation or reformation of bCD-Fc inclusion complexes.Furthermore, the material also exhibited good self-healing properties.

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“…It is known that β‐CD could interact with ferrocene and its derivatives to form stable inclusion complexes in various water environment . Here, in order to make sure that both HEMA‐Fc and βCD‐Fe 3 O 4 exhibited good solubility, a mixed solvent of (water:ethanol = 1:1) was used for the preparation of the HEMA‐Fc/βCD‐Fe 3 O 4 complex.…”

Section: Resultsmentioning

confidence: 99%

Electromagnetic Wave Absorption Coating Material with Self‐Healing Properties

Wang

Pan

Liang

et al. 2017

Macromol. Rapid Commun.

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properties. Unfortunately, considerable attention has been paid to the development of more light and higher efficient EAMs, while little work has been done on their durability. The preparation of durable EAMs is still a big challenge until now.Endowing coatings with self-healing capabilities into is a good way to enhance the coating lifetime. After damage occurs, self-healing coatings are able to heal the scratches and recover their functionality. The strategies applied for bulk polymer materials have already been used for design of self-healing polymer coatings. There are two main ways: extrinsic and intrinsic strategies. [19][20][21][22] The extrinsic ones are based on encapsulation of healing agents in the coatings. The advantages of this approach are that the self-healing process is fast, efficient and autonomous. But in the case of electromagnetic coatings, the compatibility of electromagnetic wave absorbing fillers, self-healing encapsules and polymer matrix is an intractable problem and the inhomogeneous distributions of multicontainers may cause the problem of uncontrollable properties. The intrinsic strategy bases on the inherent reversibility of chemical bonds or supramolecular interactions between the damage interfaces. [23] But using intrinsic self-healing polymer as coating is harder than construction of corresponding bulk healing materials because the strong binding between coating and underlying substrate restricts the migration of molecular chains. Especially for the functional coatings, such as electromagnetic coatings, introducing reversible interactions to polymer matrix always requires a complex synthesis process. [24] Very recently, we developed a kind of conductive elastomer with autonomic self-healing properties. [25] Without the introduction of foreign aid healing agent, or the complex synthesis of intrinsic self-healing polymer matrix, the resulting materials showed self-healing ability owing to the host-guest interactions between functional fillers (nanotube), and the classic polymer matrix. In this paper, we further expand this design strategy for the preparation of electromagnetic absorbing coatings. A kind of self-healing coating with good electromagnetic absorbing properties was prepared by connecting the electromagnetic wave absorbing fillers and classic polyacrylate coating through host-guest interactions. When the coating thickness is 4 mm, the reflection loss (RL) below −10.0 dB at 8.7-18.0 GHz and minimum values reaches 27.2 dB. After being damaged, the cracks on this coating can be healed completely with the aid of small amounts of water; simultaneously, the electromagnetic absorbing ability of the coating is restored along with the self-healing process. Fe 3 O 4 nanoparticles were selected as Electromagnetic Wave Absorbing Materials Electromagnetic wave absorption coatings can effectively minimize electromagnetic radiation and are widely used in the military and civil field. However, even small scratches on the coating can lead to a large decline of absorption ability and bri...

show abstract

Correlation of the formation constant of ferrocene–cyclodextrin complexes with dielectric properties of the aqueous DMSO solution

Cited by 14 publications

References 30 publications

Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer

Inclusion Complex of Novel Curcumin Analogue CDF and β-Cyclodextrin (1:2) and Its Enhanced In Vivo Anticancer Activity Against Pancreatic Cancer

A reversible functional supramolecular material formed by host–guest inclusion

Electromagnetic Wave Absorption Coating Material with Self‐Healing Properties

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