Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium(IV) complexes

Naso, Luciana G.; Ferrer, Evelina G.; Williams, Patricia Ana María

doi:10.1016/j.ccr.2023.215271

Cited by 5 publications

(2 citation statements)

References 129 publications

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“…However, it is important to note that these molecules are not approved as drugs by regulatory authorities. These include oxidovanadium(IV) complexes of flavonoids, such as chrysin ( Figure 1 I), morin, silibinin, and quercetin, which showed antitumor properties for breast cancer and osteosarcoma, among others [ 40 , 46 , 116 ]. Other vanadium complexes with anticancer properties include phenanthroline ligands, which show antiparasitic activity [ 117 ], as well as salicylaldimines and aromatic heterocycles [ 118 ].…”

Section: Discussionmentioning

confidence: 99%

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

De Sousa-Coelho,

Fraqueza,

Aureliano

2023

Pharmaceuticals

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Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy—many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs, potentially improving their efficacy in cancer treatment. In this review, covering the last 25 years of research in the field, we identified non-oncology-approved drugs suitable as ligands to obtain different vanadium complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs, and cetirizine and imidazole-based oxidovanadium(IV) complexes, each has a parent drug known to have different medicinal properties and therapeutic indications, and all showed potential as novel anticancer treatments. Nevertheless, the precise mechanisms of action for these vanadium compounds against cancer are still not fully understood.

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Section: Discussionmentioning

confidence: 99%

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

De Sousa-Coelho,

Fraqueza,

Aureliano

2023

Pharmaceuticals

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“…In assessing naringin's performance individually in the A549 lung cancer cell line, we noted limited anticancer activity within the tested concentrations. 8 However, the complex exhibited a reduction in cell viability, attributed to its pro-oxidant effects. In the context of our ongoing research, we have undertaken the synthesis and thorough characterization of a novel ternary complex, [VONargPhenCl]Á3H 2 O (VONargPhenCl).…”

Section: Introductionmentioning

confidence: 99%

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Restrepo,

Huamani,

Velásquez Bravo

et al. 2024

New J. Chem.

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Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy

Lu,

Li,

2024

Advanced Materials

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Cuproptosis is a novel copper‐dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self‐amplified cuproptosis nanoparticles (Cel‐Cu NP) using celastrol (Cel), a natural product isolated from medical plant. In Cel‐Cu NP, Cel serves as a versatile copper ionophore, exhibiting an ideal coordination capacity toward copper ions without compromising the cuproptosis induction. Notably, Cel can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, this self‐amplified cuproptosis further activates immunogenic cell death (ICD) to elicit robust immune response. Combining with immune checkpoint blockade, Cel‐Cu NP effectively eradicates metastatic tumors in a mouse lung metastasis model. This study provides an efficient nanomedicine by inducing self‐amplified cuproptosis for robust immunotherapy.

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Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium(IV) complexes

Cited by 5 publications

References 129 publications

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer

Influence of the secondary ligand, phenanthroline, on the antioxidant and pro-oxidant and cytotoxic effects of the oxidovanadium(iv)/naringin complex

Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy

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