Correlation of Systemic and Developmental Toxicities with Chemical Component Classes of Refinery Streams

Systemic and Developmental Toxicity of Dermally Applied Syntower Bottoms in Rats

“…Based on our knowledge of the chemical components of refinery streams and their correlation with toxic effects in rats (Feuston et al, 1994a), it was not surprising that STB is a systemic and developmental toxicant. Comparable toxic effects have been observed in rats exposed dermally to CSO Feuston et al, 1989), a refinery stream with an analytical profile that is similar to that of STB (Table 1).…”

“…A correlation between the results in the Ames test and both PAC concentration and systemic/developmental toxicity has been established and suggests that toxicity may result from the same PAC metabolites responsible for carcinogenic and mutagenic effects (Feuston et ai, 1994a). General associations between observed adverse effects and (Mackerer and Mehlman, 1989;Feuston et al, 1994a) for these streams, but the individual data were not included. The results of this present investigation contributed toward establishing that relationship.…”

The Mammalian Toxicological Hazards of Petroleum-Derived Substances

“…A series of articles describing the development of the method and its applications has been published elsewhere (eg, Gray et al 2 ). A previous publication based on a series of repeated dose and developmental toxicity tests of a series of high boiling point refinery streams showed that these substances produced similar target organ and developmental effects and that these effects were associated with PAC content 33 ; however, quantitative relationships between the levels of PACs in the test samples and outcomes measured in the toxicity tests were not defined. A related and also very important observation was that the aliphatic constituents of these substances made no apparent contribution to the toxicological properties.…”

“…The ULSD did not produce target organ effects or developmental effects at treatment levels up to 600 mg/kg/d, whereas treatment with the aromatic-rich streams increased liver weights, reduced maternal thymus weights, and reduced certain hematological parameters and also produced developmental effects in a manner related to the levels and types of aromatics present in the specific gas oil streams tested. 33,64 The new data from the HPV program provided additional information showing that the target organ and developmental effects are associated with PACs.…”

“…68 The CCCO causes skin tumors in repeated dose dermal studies in mice. 69,70 In developmental toxicity tests, CCCO reduces fetal survival and increases the frequency of resorption 33,[71][72][73][74][75] but has no effects on reproductive parameters. 63 Repeated dose and developmental toxicity tests of CCCO, conducted as part of the HPV program, produced results consistent with previous reports.…”