Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis

Abstract

Correlation of synovial uid HMGB-1 levels with radiographic severity of knee osteoarthritis Abstract Purpose: is study measured high-mobility group box 1 (HMGB-1) levels in serum and synovial uid (SF) in patients with primary knee osteoarthritis (OA) and correlated these levels with radiographic disease severity.Methods: Seventy-eight OA patients and 30 controls were enrolled in this study. All OA patients were scored according to the Kellgren-Lawrence (KL) grading system. HMGB-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).Results: SF HMGB-1 levels were signi cantly higher in knee OA patients, compared with controls (P<0.01). Moreover, SF HMGB-1 levels were positively associated with KL scores (P<0.01). Multinomial logistic regression demonstrated that the SF HMGB-1 level was an independent factor for radiographic severity of OA (P=0.002); however, serum HMGB-1 levels did not di er signi cantly between OA patients and controls and did not correlate with KL scores (P>0.05).Conclusion: ese results demonstrate that HMGB-1 levels in SF of knee OA patients are independently associated with radiographic disease severity.

IL‐1β mediating high mobility group box protein‐1 expression in condylar chondrocyte during temporomandibular joint inflammation

“…HMGB‐1 has been demonstrated to be important in the pathogenesis of OA . Previous studies have proved that synovial fluid HMGB‐1 levels were significantly higher in knee OA patients, and were independent factors for radiographic severity of OA . Furthermore, histological grades of OA were proved to be correlated with the HMGB‐1 grade .…”

High‐mobility group box‐1 in sterile inflammation

“…In addition to its roles in acute sterile inflammation, HMGB1 also mediates chronic inflammatory processes (Table ). Specifically, HMGB1 is important in the pathogenesis of rheumatoid diseases . Serum levels of HMGB1 in most of these diseases are significantly higher in comparison with healthy controls and are correlated to the extent of disease activity.…”

“…Serum levels of HMGB1 in most of these diseases are significantly higher in comparison with healthy controls and are correlated to the extent of disease activity. In osteoarthritis, HMGB1 levels are significantly higher in the synovial fluid of patients, and anti‐HMGB1 antibodies inhibit the development of synovial inflammation and joint swelling in experimental models of arthritis . Similarly, biopsy specimens from rheumatoid synovitis reveal aberrant HMGB1 expression associated with joint destruction , whilst injection of HMGB1 into joints can cause long‐lasting destructive arthritis .…”

Response of osteoarthritis biomarkers after a rehabilitation program: study protocol

“…19,[29][30][31] Recent study showed a correlation between synovial fluid levels of HMGB-1 and disease severity of primary knee OA, suggesting the HMGB-1 as a possible OA biomarker prognostic. 32 Considering that OA is an inflammatory disease, the importance of the understanding of the effect of rehabilitation treatment in the systemic inflammatory profile is crucial for rehabilitative treatment.…”