Correlation of Spot Urine Protein:Creatinine Ratio with 24-hour Urinary Protein in Preeclampsia: A Cross Sectional Study

Kashinakunti, Sangappa Virupaxappa; Manjula, R; Kallaganada, Gurupadappa; Hiremath, Kavita

doi:10.9734/bjmmr/2015/14437

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…In our study, Fisher's exact test depicted a posi ve assoscia on between Urine protein/ crea nine ra o with 24-hour urine protein found (p < 0.05). There was a significant correla on between 24-hour protein excre on and the urine protein/crea nine ra o (r = 0.828, p < 0.0001) 7 in the study done by Kayatas S et al Similar findings was 8 noted in the study done by Kashinakun SV et al…”

Section: Discussionsupporting

confidence: 78%

Study of Protein/creatinine Ratio in Preeclampsia as an Alternative to 24 Hours Urine Protein in Manipal Teaching Hospital of Nepal

Shrestha

2018

Birat J. Health Sci.

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Introduction: Hypertensive disorder in pregnancy complicates around 5 to 10% of all pregnancies. It is one of the leading causes of maternal and fetal morbidity and mortality. Measurement of protein excretion by 24 -hour urine protein collection is gold standard but as it is time consuming, an alternative method like random urine protein/creatinine ratio is required.Objectives: The aim of this study was to assess the diagnostic accuracy of urine protein/ creatinine ratio compared with 24-hour urine protein as an alternative method for evaluating proteinuria in preeclampsia.Methodology: Patients with preeclampsia after 20 weeks of gestation were included in the study. Random urine protein/ creatinine ratio and 24-hour urine for protein was collected and evaluated for proteinuria. Results were entered and analysis was done.Results: Fisher's exact test depicted a positive association between UPCR with 24-hour urine protein, p value being less than 0.05. The area under curve was calculated as 0.87 95% CI (0.74-1.01), which was statistically significant. At cut off point of 0.3, sensitivity was 100%, specificity 90%, positive and negative predictive value 97.2% and 100% respectively.Conclusion: Random urine protein/ creatinine ratio (>0.3) is a reliable indicator of proteinuria >300mg/day. It can be used as an alternative to 24-hour protein estimation. BJHS 2018;3(1)5 : 350-353

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Section: Discussionsupporting

confidence: 78%

Study of Protein/creatinine Ratio in Preeclampsia as an Alternative to 24 Hours Urine Protein in Manipal Teaching Hospital of Nepal

Shrestha

2018

Birat J. Health Sci.

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A Study of Correlation of Spot Urine Protein-Creatinine Ratio With 24hour Urinary Protein in Type 2 Diabetes Mellitus Patients at a Tertiary Care Hospital

Upadhyay

Patel

Shah

et al. 2021

PIJR

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Background:Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management. Method: The present study is a prospective observational study conducted amongst 50 diabetic subjects in Medicine department & IKDRC,Civil Hospital Ahmedabad.The study carried out during the period between July 2017 to October 2019. All patients were treated as per standard treatment protocol. 24-hour urine protein and random urine protein to creatinine ratio (P:C) was determined. Result: Total 50(24 male &26 female) patients were studied. A strong correlation was found between 24 hours urine protein and protein- Creatinine ratio, especially in patient with eGFR >30 (CKD stage I to III) with coefficient of correlation of 0.973.However correlation weaken as the GFR worsens and is weakest in patients with stage 5 CKD Conclusion: The random urine Protein:Creatinine ratio predicts the amount of 24-hour urinary protein excretion with high accuracy.Hence it can be used as a faster substitute test for 24-hour urinary protein estimation.

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Correlation of Spot Urine Protein:Creatinine Ratio with 24-hour Urinary Protein in Preeclampsia: A Cross Sectional Study

Cited by 2 publications

References 29 publications

Study of Protein/creatinine Ratio in Preeclampsia as an Alternative to 24 Hours Urine Protein in Manipal Teaching Hospital of Nepal

Study of Protein/creatinine Ratio in Preeclampsia as an Alternative to 24 Hours Urine Protein in Manipal Teaching Hospital of Nepal

A Study of Correlation of Spot Urine Protein-Creatinine Ratio With 24hour Urinary Protein in Type 2 Diabetes Mellitus Patients at a Tertiary Care Hospital

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