Correlation of serum resistin level with insulin resistance and severity of retinopathy in type 2 diabetes mellitus

Azab, Naglaa; Abdel-Aziz, Taher; Ahmed, A.Y.; El‐Deen, Ibrahim M.

doi:10.1016/j.jscs.2012.07.003

Cited by 16 publications

(17 citation statements)

References 40 publications

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“…In this study, there were no significant correlations between the level of resistin and fasting blood sugar, hemoglobin A1C, serum creatinine, and body mass index. These results are similar to the ones obtained by Cebeci et al (13) and contrary to the results by Azab et al (17). Also, serum resistin level had a weak inverse correlation with the glomerular filtration rate, which can be due to kidney problems in patients with high levels of resistin.…”

Section: Discussionsupporting

confidence: 88%

“…It seems that neuropathy does not affect the fasting blood sugar level in patients with type-2 diabetes because it was critically higher in both diabetic groups with/without nephropathy than the healthy individuals, but there was no significant difference between the two groups. The body mass index of the three groups participating in the experiment was not significantly different from each other, the result of which is inconsistent with the results obtained in the study conducted by Satti et al (12), Cebci et al (13), and Azab et al (17). The reason for the lack of this relationship could be this, considering that the body mass index of the subjects did not have the necessary scope (highest: 48.82, average: 27.1, lowest: 19.48) and the index of most patients was in the low range (healthy subjects = 25.7 ± 0.5, diabetic without nephropathy (27.8 ± 0.1), diabetic with nephropathy (27.8 ± 0.9).…”

Section: Discussioncontrasting

confidence: 85%

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The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

Tofangchiha

Rahimi

Mirzaii‐Dizgah

et al. 2020

Ann Mil Health Sci Res

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Background: Resistin reduces tissue sensitivity to insulin and causes hyperglycemia. Diabetic nephropathy is also a metabolic disorder caused by chronic hyperglycemia that causes kidney dysfunction. Objectives: This study aimed to investigate the relationship between serum resistin and diabetic nephropathy in diabetic patients who referred to Imam Reza Hospital in 2018 - 2019. Methods: This case-control study recruited 30 diabetic patients with nephropathy, 29 non-nephropathy diabetic patients, and 30 healthy controls via convenience sampling. Serum and 24-hour urine samples were taken from each person. After the determination of the glomerular filtration rate, samples were tested in a laboratory. Also, data were analyzed by SPSS software version 23, and P < 0.05 was considered significant. Results: Mean serum resistin was significantly different between the groups (F = 3.600, P = 0.032). Tukey’s follow-up test showed that resistin was critically higher in the diabetic nephropathy group than in the control group and healthy controls. There was a weak inverse relationship between glomerular filtration rate and serum resistin level (r = -0.233, P = 0.031). Conclusions: Levels of resistin may rise in people with diabetes associated with nephropathy. It seems that Serum resistin can be used as a biomarker to assess the severity of diabetes mellitus.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 85%

The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

Tofangchiha

Rahimi

Mirzaii‐Dizgah

et al. 2020

Ann Mil Health Sci Res

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“…Resistin showed similar results compared with serum resistin levels of Egyptians and Japanese although slightly lower [35,36]. …”

Section: Discussionmentioning

confidence: 99%

“…Our study population showed higher basal adiponectin and leptin serum levels than have been reported in other similar studies, for example, in German [ 31 ], Finnish [ 32 ], Japanese [ 8 ], Asian Indian [ 33 ], and Arabic diabetic populations [ 34 ], which is likely to be due to ethnicity. Resistin showed similar results compared with serum resistin levels of Egyptians and Japanese although slightly lower [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus Patients

et al. 2017

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Background: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. Methods: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily. Baseline and 24-week anthropometric and biochemical measurements included glucose, insulin, glycosylated hemoglobin (Hb1Ac), leptin, adiponectin, resistin, and lipid profile; n-3 PUFA intake was calculated in g/day. Results: Waist circumference and blood glucose showed significant reductions in the FOG group (p = 0.001 and p = 0.011, respectively). Hb1Ac (p = 0.009 and p = 0.004), leptin (p < 0.000 and p < 0.000), and leptin/adiponectin ratio (p < 0.000 and p < 0.000) decreased significantly in both groups after 24 weeks (FOG and PG respectively). Serum resistin (FOG p < 0.000 and PG p = 0.001), insulin (FOG p < 0.000 and PG p < 0.000), and HOMA-IR (FOG p = 0.000 and PG p < 0.000) increased significantly in both groups. FOG had an overall improvement in the lipid profile with a significant decrease in triacylgycerols (p = 0.002) and atherogenic index (p = 0.031); in contrast, the PG group had increased total cholesterol (p < 0.000), non-HDL cholesterol (p < 0.000), and atherogenic index (p = 0.017). Conclusions: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.

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“…Heightened serum levels of resistin are present in diet‐induced obese mice and in diabetic mice . In humans, a significant positive correlation between fasting serum resistin levels, C‐reactive protein (inflammation biomarker), insulin resistance, fasting blood glucose levels, body mass index, and triglycerides was found and it was associated with T2DM‐induced retinopathy . The production of human resistin from macrophages and PBMCs is escalated upon treatment with lipopolysaccharide and proinflammatory cytokines while on the other hand, presence of human resistin also induces production of proinflammatory adipocytokines, leading to a vicious cycle of chronic inflammation .…”

Section: Cytokines and Therapies That Modulate Their Activitymentioning

confidence: 99%

Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies

Banerjee

Singh

2019

Bioengineering & Transla Med

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Obesity-associated type 2 diabetes mellitus (T2DM) is characterized by low-grade chronic systemic inflammation that arises primarily from the white adipose tissue. The interplay between various adipose tissue-derived chemokines drives insulin resistance in T2DM and has therefore become a subject of rigorous investigation. The adipocytokines strongly associated with glucose homeostasis include tumor necrosis factor-α, various interleukins, monocyte chemoattractant protein-1, adiponectin, and leptin, among others. Remodeling the adipose tissue inflammasome in obesity-associated T2DM is likely to treat the underlying cause of the disease and bring significant therapeutic benefit. Various strategies have been adopted or are being investigated to modulate the serum/tissue levels of pro-and anti-inflammatory adipocytokines to improve glucose homeostasis in T2DM. These include use of small molecule agonists/inhibitors, mimetics, antibodies, gene therapy, and other novel formulations. Here, we discuss adipocytokines that are strongly associated with insulin activity and therapies that are under investigation for modulation of their levels in the treatment of T2DM.

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Correlation of serum resistin level with insulin resistance and severity of retinopathy in type 2 diabetes mellitus

Cited by 16 publications

References 40 publications

The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

The Relationship Between Serum Resistin Levels and Diabetic Nephropathy in Type 2 Diabetic Patients

Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus Patients

Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies

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