Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy

Sachan, Rekha; Patel, Munna Lal; Gaurav, Amrita; Gangwar, Radheshyam; Sachan, Pushpalata

doi:10.4103/2277-9175.145690

Cited by 14 publications

(12 citation statements)

References 32 publications

(31 reference statements)

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“…They also evaluated urine NGAL levels and found no difference between preeclampsia and control groups. D'Anna et al (13), Stepan et al (19), Artunc-Ulkumen et al (24) and Sachan et al (25) detected that NGAL had a positive correlation with systolic and diastolic blood pressure, in accordance with results of our study. D'Anna et al (13,15) observed that serum NGAL had a positive correlation with proteinuria in preeclampsia.…”

Section: Discussionsupporting

confidence: 91%

“…Sachan et al (25) have shown that serum NGAL was increased in women with preeclampsia compared to the controls, in women with eclampsia compared to severe preeclampsia, in women with severe preeclampsia compared to the women with mild preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

“…Artunc-Ulkumen et al (24) reported that serum NGAL had a positive correlation with proteinuria in spot urine and 24-hour urine tests. Sachan et al (25) detected that serum NGAL had a positive correlation with blood urea nitrogen, creatinine, and uric acid; and serum NGAL levels were significantly higher in oliguric compared to non-oliguric pregnant women. Simonazzi et al (26) found that urine NGAL had a positive correlation with a 24-hour urine test.…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Güralp

Tüten²,

Öncül

et al. 2020

Gynecol Obstet Reprod Med

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Objective: To evaluate the serum neutrophil gelatinase-associated lipocalin levels in pregnant women with and without preeclampsia, early-onset preeclampsia and late-onset preeclampsia, preeclampsia with and without severe features, and investigate the correlation with the neonatal outcomes.Study Design: A total of 79 pregnant women, 27 with uncomplicated pregnancies, 30 with early-onset preeclampsia, and 22 with late-onset preeclampsia were evaluated in a cross-sectional study. Neutrophil gelatinase-associated lipocalin was measured with a colorimetric Sandwich-ELISA method. Age; body mass index; systolic and diastolic blood pressure; umbilical-artery Doppler results; serum urea, bilirubin, uric acid, AST, ALT; 24-hour protein test; birth-weight; and Apgar-scores were recorded. Results: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia (p<0.001); in women with early-onset preeclampsia compared to those with late-onset preeclampsia (p<0.001); and in women with late-onset preeclampsia compared to those without preeclampsia (p=0.028). Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features (p=0.076). The correlation analysis showed that neutrophil gelatinase-associated lipocalin was not affected by age or body mass index. Neutrophil gelatinase-associated lipocalin had a positive correlation with systolic and diastolic blood pressure and the umbilical-artery PI and RI. Serum neutrophil gelatinase-associated lipocalin had a positive correlation with serum urea (r=0.416, p=0.031) however had no significant correlation with birth-weight, Apgar-scores, uric acid and amount of proteinuria in women with preeclampsia. Conclusion: Serum neutrophil gelatinase-associated lipocalin levels were significantly higher in women with preeclampsia compared to those without preeclampsia; in women with early-onset preeclampsia compared to those with late-onset preeclampsia, and in women with late-onset preeclampsia compared to women without preeclampsia. Mean serum neutrophil gelatinase-associated lipocalin levels were comparable in women with preeclampsia with and without severe features.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Güralp

Tüten²,

Öncül

et al. 2020

Gynecol Obstet Reprod Med

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“… 11 found that urinary NGAL concentrations of 110 ng/mL were associated with a sensitivity of 88% and a specificity of 85% for the diagnosis of non-prerenal AKI in decompensated cirrhosis patients. NGAL is an independent predictor of irreversible kidney function injury, and thus might be independent of other commonly used risk factors for predicting patient mortality 21 . The present study also found that urinary NGAL levels were significantly higher in the group with AKI secondary to decompensated cirrhosis than in the non-AKI and healthy control groups, and that urinary NGAL levels increased significantly with AKI progression.…”

Section: Discussionmentioning

confidence: 99%

Value of urinary KIM-1 and NGAL combined with serum Cys C for predicting acute kidney injury secondary to decompensated cirrhosis

Lei

Zeng

et al. 2018

Sci Rep

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Urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and serum cystatin C (Cys C) are biomarkers of acute kidney injury (AKI). However, the efficacy of combining these indices to diagnose decompensated cirrhosis is unknown. This study involved 150 patients divided into AKI and non-AKI, and healthy individuals. Urinary KIM-1 and NGAL, serum Cys and creatine, and glomerular filtration rate (GFR) were compared based on Child-Pugh liver function class. Urinary KIM-1 and NGAL concentrations and serum Cys C levels were significantly higher in patients with AKI secondary to decompensated cirrhosis than in those with AKI not secondary to decompensated cirrhosis (p < 0.01). These were significantly associated with higher kidney injury index stages (p < 0.01) and negatively correlated with GFR in secondary AKI patients. Urinary KIM-1 and NGAL and serum Cys C increased significantly and GFR decreased as Child-Pugh class of decompensated cirrhosis significantly increased (p < 0.05). SCr levels were significantly increased in Child-Pugh class C patients (p < 0.05). Urinary KIM-1, urinary NGAL, serum Cys C, and the combined detection factor, as screening indices, could aid in the early diagnosis of AKI secondary to decompensated cirrhosis.

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“…For several decades, lots of biomarkers that can predict AKI were introduced to promptly initiate aggressive kidney-sparing and life-saving treatment [16]. These biomarkers mainly include kidney injury molecule-1 (KIM-1) [17], neutrophil gelatinase-associated lipocalin (NGAL) [18], and serum cystatin C (CYS-C) [19].…”

Section: Introductionmentioning

confidence: 99%

Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis

et al. 2018

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Aims The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis. Methods A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients (n = 237) diagnosed with acute pancreatitis without any renal injury. The following information including age, gender, serum creatinine, serum urea nitrogen, serum uric acid, serum cystatin C, fasting serum glucose, serum amylase, serum lipase, serum choline esterase, total protein, albumin, globulin, total bilirubin, direct bilirubin, total bile acids, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, gamma glutamyl transpeptidase, and alkaline phosphatase were collected from each patient when they were diagnosed with acute pancreatitis. Student t-test was conducted to figure out the difference between patients with and without AKI. Univariate and multivariate logistic regression analyses were used for investigating the predictors for AKI in patients with acute pancreatitis. Results 18 (7.6%) patients in total had developed AKI among the study group. Compared with patients without AKI (1.01 ± 0.26 mg/L), the level of baseline serum cystatin C (CYS-C) was significantly higher in patients with AKI (3.64 ± 2.17 mg/L, P < 0.001). Baseline serum CYS-C (OR = 203.594, P < 0.001) was the independent and significant predictor for AKI in patients with acute pancreatitis. AKI in patients with acute pancreatitis could be identified with a sensitivity of 88.9% at specificity of 100% (AUC = 0.948, 95% CI 0.879–1.000) by baseline serum CYS-C (cut-off value = 1.865 mg/L). Conclusions Baseline serum CYS-C shall be adopted to predict the potential risk of AKI in patients with acute pancreatitis.

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Correlation of serum neutrophil gelatinase associated lipocalin with disease severity in hypertensive disorders of pregnancy

Cited by 14 publications

References 32 publications

Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Neutrophil Gelatinase-Associated Lipocalin Levels in Early and Late Onset Preeclampsia

Value of urinary KIM-1 and NGAL combined with serum Cys C for predicting acute kidney injury secondary to decompensated cirrhosis

Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis

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