Correlation of serum levels and gene expression of tumor necrosis factor-α-induced protein-8 like-2 with Parkinson disease severity

Kouchaki, Ebrahim; Kakhaki, Reza Daneshvar; Tamtaji, Omid Reza; Dadgostar, Ehsan; Behnam, Mohammad; Zaribaf, Alireza; Nikoueinejad, Hassan; Akbari, Hossein; Asemi, Zatollah

doi:10.1007/s11011-018-0302-7

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…In addition, Cystatin C was able to predict the severity of sleep-disordered breathing associated with PD [ 171 ]. Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) has been postulated as a good prognosis biomarker [ 238 ]. However, other proteins such as DJ-1 were not considered good biomarkers since their levels did not differ between PD and HC [ 237 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

Mayo

Benito‐León

Peña-Bautista

et al. 2021

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Background: Alzheimer’s (AD) and Parkinson’s diseases (PD) show deposits of improperly folded modified proteins, so protein expression mechanisms are involved since early stages. Several studies evaluated epigenomics and proteomics profiles in these patients, with promising results. In general, they focused on early, specific, and minimally invasive biomarkers for diagnosis and prognosis of AD and PD. Objectives: This review aimed at summarizing results to find the most reliable evidence in the field. Method: A PubMed search was carried out. It was limited to the last 6 years, using a combination of search terms related to AD, PD and epigenetics or proteomics. Results: Among epigenomics studies, most of them focused on microRNAs (miRNAs) as candidate diagnosis biomarkers for AD or PD from blood samples like miR-342-3p, miR-107, miR-106a-5p, miR-106b-5p, miR-195, and miR-19b. In addition, the DNA methylation has been tested in a few works, obtaining significant differences in some genes (NCAPH2/LMF2 COASY, SPINT1, BDNFTREM1, TREM2, NPAS2, PDE4D), which could be useful for evaluating the disease progression as well as potential risk factors. Regarding proteomics, most of the studies were untargeted and used plasma or serum samples. In general, they highlighted the importance of coagulation, inflammation pathways, and oxidative stress. Among targeted studies, some proteins (phosphorylated tau, C reactive protein (CRP), interleukins, necrosis factors, transferrin, glial fibrillary acidic protein (GFAP),and neurofilaments) showed different plasma levels in AD and PD patients in comparison with healthy participants. Finally, a few studies have identified specific-AD and PD epigenetic and proteomic biomarkers (ApoE and oxidized DJ-1) in comparison with other similar pathologies. Conclusion: In general, there is a common lack of clinical validation of these potential biomarkers, for which its use in the clinical practice is still limited.

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Section: Resultsmentioning

confidence: 99%

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

Mayo

Benito‐León

Peña-Bautista

et al. 2021

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“…They further showed that enhanced serum levels of TIPE2 possess a direct correlation with age and severity of patients with Parkinson’s diseases. Besides, TIPE2 expression was also found to be strongly linked with the age of the patients [ 94 ] ( Figure 2 G).…”

Section: Role Of Tipe Family Of Proteins In Different Chronic Disementioning

confidence: 99%

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

Bordoloi

Banik

Shabnam

et al. 2018

IJMS

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The tumor necrosis factor-α-induced protein 8-like (TIPE/TNFAIP8) family is a recently identified family of proteins that is strongly associated with the regulation of immunity and tumorigenesis. This family is comprised of four members, namely, tumor necrosis factor-α-induced protein 8 (TIPE/TNFAIP8), tumor necrosis factor-α-induced protein 8-like 1 (TIPE1/TNFAIP8L1), tumor necrosis factor-α-induced protein 8-like 2 (TIPE2/TNFAIP8L2), and tumor necrosis factor-α-induced protein 8-like 3 (TIPE3/TNFAIP8L3). Although the proteins of this family were initially described as regulators of tumorigenesis, inflammation, and cell death, they are also found to be involved in the regulation of autophagy and the transfer of lipid secondary messengers, besides contributing to immune function and homeostasis. Interestingly, despite the existence of a significant sequence homology among the four members of this family, they are involved in different biological activities and also exhibit remarkable variability of expression. Furthermore, this family of proteins is highly deregulated in different human cancers and various chronic diseases. This review summarizes the vivid role of the TIPE family of proteins and its association with various signaling cascades in diverse chronic diseases.

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“…Dopaminergic neuron loss is known as hallmark of PD (Sulzer, 2007). The different molecular mechanisms are responsible for the pathophysiology of PD, including microglia activation (Sarkar, Lu, Raymick, Hanig, & Gu, 2018), change in astrocytes (De Miranda et al, 2018), increase in oxidative stress (Monzani et al, 2018) and inflammatory cytokines (Kouchaki, Daneshvar Kakhaki et al, 2018;, aggregation of α-synuclein (W. Zhang et al, 2005), neurotransmission (Barone, 2010), synaptic plasticity (Pisani, Centonze, Bernardi, & Calabresi, 2005), adult neurogenesis (Marxreiter, Regensburger, & Winkler, 2013), brain lymphatic drainage system (B.-L. Sun et al, 2018), and changes in expression of aquaporins (AQPs; Badaut et al, 2008;Thenral & Vanisree, 2012).…”

Section: Introductionmentioning

confidence: 99%

Aquaporin 4: A key player in Parkinson's disease

Tamtaji

Behnam

Pourattar

et al. 2019

Journal Cellular Physiology

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Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases which occur in aged people worldwide. Given that a sequence of cellular and molecular mechanisms, including oxidative stresses, apoptosis, inflammatory pathways, microglia, astrocyte activation, and aquaporin 4 (AQP4) are associated with initiation and the progression of PD. AQP4 may affect various pathways (i.e., α-synuclein, inflammatory pathways, and microglia and astrocyte activation). Few reports have evaluated the relationship between AQP4 and PD-related cellular and molecular pathways. Here, for the first time, we highlighted the relationship between AQP4 and molecular mechanisms involved in PD pathogenesis.aquaporin 4, astrocyte, microglia, Parkinson disease, α-synuclein

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Correlation of serum levels and gene expression of tumor necrosis factor-α-induced protein-8 like-2 with Parkinson disease severity

Cited by 16 publications

References 29 publications

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

TIPE Family of Proteins and Its Implications in Different Chronic Diseases

Aquaporin 4: A key player in Parkinson's disease

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