Correlation of serum interleukin-10 level with disease activity and severity in systemic lupus erythematosus

Elazeem, Mervat I. Abd; Mohammed, Rabab; Abdallah, Nilly

doi:10.4103/err.err_15_17

Cited by 14 publications

(22 citation statements)

References 35 publications

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“…The current study reports that young adults are more likely to have abnormal IL-10 and IL-17. However, these results disagree with previous studies [22,23]. No association was found between age and OPN level.…”

Section: Discussioncontrasting

confidence: 99%

Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients

et al. 2021

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Background: Rheumatoid arthritis (RA) is associated with abnormal liver tests, and the medications used for RA are often hepatotoxic. Therefore, this study aimed to investigate an association between pro-inflammatory and anti-inflammatory cytokines and liver function tests in RA patients. Methods: In this descriptive cross-sectional study, 88 RA patients were included, 84 of them were women and 4 men, aged 21–81 years. Serum interleukin-10 (IL-10), interleukin-17 (IL-17), Osteopontin (OPN) were measured and liver function tests were conducted. Results: The frequency of RA was higher among adults aged >41 years (72 [81.8%]) than young adults aged ≤41 years (16 [18.2%]). RA was more common in women (84 [95.5%]) than in men (4 [4.5%]) – approximately 21:1-fold. Young adults had higher abnormal IL-10 than adult RA patients (OR = 3.72, p-value 0.044). Abnormal IL-17 (OR = 5.67, p-value 0.034) was found to be increased in young-adult RA patients. No association was observed between age and OPN and between the duration of disease and IL-10, IL-17, and OPN. Similarly, no association was noted between the types of treatment and IL-10, IL-17, and OPN, nor between IL-10, IL-17, OPN and liver parameters (AST, ALT, ALP, ALB, TP, and GGT). Conclusion: Pro-inflammatory and anti-inflammatory cytokines are not associated with abnormal liver functions, as has been demonstrated in RA patients.

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Section: Discussioncontrasting

confidence: 99%

Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients

et al. 2021

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“…In the previous studies, many laboratory markers have been used, which include serological determination of serum anti-double-stranded (ds)DNA antibodies and complement levels, and those can be helpful clinically, but the correlation between them and lupus renal disease is lacking. Sensitivity and specificity for active lupus nephritis among all SLE patients are different with different studies and tests used [5,21,22].…”

Section: Discussionmentioning

confidence: 99%

Urinary epidermal growth factor as a marker for lupus nephritis: clinical, laboratory, and histopathological study

Hefny

Abualfadl

Youssef

et al. 2021

Egypt Rheumatol Rehabil

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Background Lupus nephritis can be seen in up to 60% of all SLE patients with 10–15% of nephritis patients progressing to end-stage renal disease; late diagnosis of lupus nephritis is correlated with a higher frequency of renal insufficiency. The study aim is determination of the value of urinary human epidermal growth factor (urinary EGF) as an early biomarker of lupus nephritis in SLE patients and its relevance to disease activity and renal histopathology. Results The study included 58 SLE patients and 30 healthy controls; a significant difference was noticed between SLE and controls in urinary protein, creatinine, protein/creatinine ratio, and urinary EGF. The mean level of urinary EGF was less in classes IV and V renal nephritis than in classes I, II, and III. There is a significant difference in urinary EGF (33±29, 27±16, P = 0.04) between class II and class III lupus nephritis, with no significant differences in urinary protein, creatinine, protein/creatinine ratio, and SLEDAI. On the other hand, the comparison between classes II and IV showed significant difference not only in urinary EGF (33±29, 11.7±4.9 m, P=0.003), but also in SLEDAI (37.4±8, 70.5±27, P= 0.007), and protein/creatinine ratio (0.98±0.62, 3±1.8, P=0.006). Conclusion This study raises the attention to test the sensitivity of urinary EGF in detecting the early and the subsequent changes in renal pathology of SLE patients as an easy, non-invasive, accurate, cheap marker that could help in following up the nephritis progression and adjusting the plan of treatment; also, it can be used to guide the time of biopsy or as an alternative in cases where renal biopsy is contraindicated.

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“…This result agreed with several studies. [27][28][29][30] This difference may be attributed to the heterogeneity of the disease, different patient populations and different sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of autophagy‐related genes in Egyptian systemic lupus erythematosus patients

et al. 2020

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Disturbances in autophagy are known to be implicated in autoimmune disorders. Many studies have connected polymorphisms in autophagy‐related gene 5 (ATG‐5) to systemic lupus erythematosus (SLE). Our aim was the determination of the expression level of ATG‐5, Beclin‐1 and microtubule‐associated protein‐light chain 3 (LC‐3) in Egyptian SLE patients to investigate the impact of disturbances in autophagy genes on the incidence and progression of the disease. Also, we investigated the incidence of single nucleotide polymorphism (SNP) rs573775 in ATG‐5 gene among Egyptian SLE patients. Our results showed that the mean levels of Beclin‐1, LC‐3 and interleukin (IL)‐10 transcripts were significantly higher in SLE patients compared to healthy controls. The previous transcripts were positively correlated with SLE Disease Activity Index (SLEDAI). Beclin‐1 and LC‐3 transcripts were negatively correlated to complement component 3 (C3) levels. Only LC‐3 transcripts were negatively correlated to complement component 4 (C4). The rs573775 SNP of ATG‐5 with the variant allele was significantly associated with disease susceptibility, conferring a higher risk of SLE development. This variant allele was more prevalent in patients below 30 years, patients with anemia and in patients with anti‐double‐stranded DNA (dsDNA), confirming the essential role of ATG‐5 polymorphism in the susceptibility of Egyptian patients to SLE.

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Correlation of serum interleukin-10 level with disease activity and severity in systemic lupus erythematosus

Cited by 14 publications

References 35 publications

Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients

Association between Inflammatory Cytokines and Liver Functions in Rheumatoid Arthritis Patients

Urinary epidermal growth factor as a marker for lupus nephritis: clinical, laboratory, and histopathological study

Evaluation of autophagy‐related genes in Egyptian systemic lupus erythematosus patients

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