Correlation of serum homocysteine levels and hyperinsulinaemia with body mass index in polycystic ovarian syndrome

Bhushan, Rashmi; Sinha, Parul

doi:10.4103/jhrs.jhrs_147_21

Cited by 6 publications

(10 citation statements)

References 31 publications

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“…Other authors, however, did not find a significant association between insulin resistance and RPL in PCOS patients (26).…”

Section: Discussionmentioning

confidence: 85%

“…They described that in PCOS women, compensatory hyperinsulinemia due to insulin resistance may lead to ovarian and adrenal androgen hypersecretion. Furthermore, there is an increased level of FT due to high insulin levels suppressing hepatic production of SHBG (26).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between insulin resistance status and Hhcy in PCOS women is still a topic of debate. Some studies found a positive correlation between Hcy and insulin resistance in PCOS women, which was related to thrombosis in the fetoplacental system and may be considered as a cause of pregnancy loss (2,3,5,15,18,26). Others did not confirm this association and proposed that serum Hcy levels rise independently in PCOS women (17,27).…”

Section: Discussionmentioning

confidence: 99%

“…Hence, implantation disorders may explain "preclinical" pregnancy loss and infertility. In the later stages of pregnancy, Hhcy promotes the development of complications such as vascular dysfunction, hypertensive disorders, preeclampsia, preterm labor, preterm placental abruption, intrauterine growth retardation, and fetal death (13,15,16).…”

Section: Introductionmentioning

confidence: 99%

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Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study

Asanidze

Kristesashvili

Parunashvili

et al. 2023

IJRM

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Background: One of the reproductive medicine challenges is to determine the role of hyperhomocysteinemia in the pathogenesis of polycystic ovary syndrome (PCOS), especially in women with recurrent pregnancy loss (RPL). Objective: Determine the correlation between hyperhomocysteinemia and pregnancy outcome in women with PCOS. Materials and Methods: This case-control study involved 245 women (20-30 yr) and was conducted in Georgia, Tbilisi from 2019-2022. Of these, 175 were women with PCOS (study group) and 70 were healthy women (control group). Women with PCOS were divided into group I with RPL (n = 90), and group II with live births (n = 85). Group I was divided into subgroups A and B with and without insulin resistance. The investigation measured homocysteine (Hcy), follicle-stimulating, luteinizing, anti-Mullerian hormones, total and free testosterone were determined. To determine the ovarian volume and antral follicle count, participants also underwent an ultrasound examination. Results: In women with PCOS, the average Hcy level was significantly higher than in the controls, p < 0.05. In group I, the average Hcy level was significantly higher than in group II and controls, p < 0.05. There was no significant difference in average Hcy level between group II and controls. The average Hcy level in group I, subgroup A was significantly higher than in subgroup B, p < 0.05. The average total, free testosterone levels, and homeostatic model assessment-insulin resistance levels (HOMA-IR) in group I was significantly higher than in group II and controls. HOMA-IR in group II and controls did not differ significantly. The average anti-Mullerian hormone levels in women with PCOS were significantly higher than controls, p < 0.05. No significant difference was observed in average anti-Mullerian hormone level, ovarian volume, antral follicle count, and body mass index between the comparison groups of PCOS. In group I, a positive correlation between Hcy with HOMA-IR was detected. Conclusion: Serum Hcy levels are elevated in women with PCOS and RPL, which correlates with their insulin resistance status. Key words: Polycystic ovary syndrome, Hyperhomocysteinemia, Recurrent abortion, Insulin resistance.

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“…Other authors, however, did not find a significant association between insulin resistance and RPL in PCOS patients (26).…”

Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study

Asanidze

Kristesashvili

Parunashvili

et al. 2023

IJRM

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“…In other words, Hcy-induced cell injury occurs because the autooxidation process of Hcy is highly reactive at physiological pH and leads to the production of superoxide and hydrogen peroxide [ 55 , 56 , 57 ]. Independent studies have demonstrated that compared with PCOS-free controls, increased serum Hcy levels are significantly associated with inflammatory response, androgen excess, IR, hyperinsulinemia, and BMI in women with PCOS [ 58 , 59 , 60 , 61 ]. Compared with the normal Hcy group, patients with hyperhomocysteinemia had increased numbers of CD14 ++ CD16 + inflammatory monocytes in their peripheral blood and elevated plasma levels of interleukin-1β and interleukin-6, the two typical cytokines secreted by inflammatory monocytes [ 59 ].…”

Section: Oxidative Stress and Inflammatory Signaling In Pcosmentioning

confidence: 99%

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Szukiewicz

Trojanowski

Kociszewska

et al. 2022

IJMS

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Despite its incidence, the syndrome is poorly understood and remains underdiagnosed, and female patients are diagnosed with a delay. The heterogenous nature of this complex disorder results from the combined occurrence of genetic, environmental, endocrine, and behavioral factors. Primary clinical manifestations of PCOS are derived from the excess of androgens (anovulation, polycystic ovary morphology, lack of or scanty, irregular menstrual periods, acne and hirsutism), whereas the secondary manifestations include multiple metabolic, cardiovascular, and psychological disorders. Dietary and lifestyle factors play important roles in the development and course of PCOS, which suggests strong epigenetic and environmental influences. Many studies have shown a strong association between PCOS and chronic, low-grade inflammation both in the ovarian tissue and throughout the body. In the vast majority of PCOS patients, elevated values of inflammatory markers or their gene markers have been reported. Development of the vicious cycle of the chronic inflammatory state in PCOS is additionally stimulated by hyperinsulinemia and obesity. Changes in DNA methylation, histone acetylation and noncoding RNA levels are presented in this review in the context of oxidative stress, reactive oxygen species, and inflammatory signaling in PCOS. Epigenetic modulation of androgenic activity in response to inflammatory signaling is also discussed.

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Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis

Ulloque-Badaracco,

Al-kassab-Córdova,

Hernández-Bustamante

et al. 2024

Womens Health (Lond Engl)

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Background: Some studies have reported that homocysteine, vitamin B12, and folic acid levels are associated with polycystic ovary syndrome (PCOS), whereas other studies yielded controversial results. Objectives: This study aimed to systematize the available evidence of homocysteine, vitamin B12, and folate levels in women with and without PCOS. Design: Systematic review and meta-analysis Data Sources and Methods: A systematic search without language restrictions was performed on PubMed, Ovid/Medline, Scopus, Embase, and Web of Science. In addition, the reference lists of the selected studies were reviewed. The Newcastle–Ottawa Scale was employed to evaluate the quality of studies. The means and standard deviations of the outcomes were pooled as standardized mean differences (SMDs) with 95% confidence intervals (CI). Furthermore, the DerSimonian and Laird method was employed for the quantitative synthesis. Results: A total of 75 studies met the eligibility criteria for at least one outcome. Patients with PCOS had higher circulating homocysteine levels than those without (SMD: 0.82; 95% CI: 0.62–1.02, n = 70 studies, p < 0.001). This trend remained in the sensitivity and subgroup analyses by world regions of studies, assay methods, and insulin resistance. No significant differences were observed in circulating vitamin B12 (SMD: −0.11; 95% CI: −0.25 to 0.03; n = 17 studies, p = 0.13) and folate levels (SMD: −0.2; 95% CI: −0.68 to 0.27; n = 17 studies, p = 0.41) between patients with and without PCOS. Conclusions: (i) Patients with PCOS exhibited significantly higher homocysteine levels than those without, and (ii) no significant differences were observed in both vitamin B12 and folate levels in women with and without PCOS. Registration: PROSPERO ID (CRD42023432883)

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Correlation of serum homocysteine levels and hyperinsulinaemia with body mass index in polycystic ovarian syndrome

Cited by 6 publications

References 31 publications

Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study

Hyperhomocysteinemia and pregnancy outcomes in women with polycystic ovary syndrome: A case-control study

Modulation of the Inflammatory Response in Polycystic Ovary Syndrome (PCOS)—Searching for Epigenetic Factors

Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis

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