Correlation of serum estradiol level on the day of ovulation trigger with the reproductive outcome of intracytoplasmic sperm injection

Siddhartha, N; Reddy, Shilpa; Pandurangi, Monna; Tamizharasi, M; Vembu, Radha; Kanimozhi, K

doi:10.4103/0974-1208.178631

Cited by 17 publications

(21 citation statements)

References 15 publications

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“…In our retrospective study, the E 2 on the day of HCG was positively correlated with oocytes retrieved, but the E 2 on the day of HCG was not correlated with pregnancy rates and could not be used to predict pregnancy in antagonist cycles, which is consistent with previous findings (29)(30)(31)(32)(33).…”

Section: Discussionsupporting

confidence: 81%

“…Some researchers have concluded that E 2 >4,000 pg/ml or E 2 >5,000 pg/ml on the day of HCG had a significantly higher number of oocytes retrieved compared to other groups (30,31). Siddhartha et al (32) conducted a retrospective study on the association of supraphysiological E 2 level with the reproductive outcome of ICSI. The study subjects were grouped based on the serum E 2 level on the day of HCG: group 1, <1,000 pg/ml; group 2, 1,000-2,000 pg/ml; group 3, 2,000.1-3,000 pg/ml; group 4, 3,000.1-4,000 pg/ml; group 5, 4,000.1-5,000 pg/ml.…”

Section: Discussionmentioning

confidence: 99%

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Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Wang

et al. 2017

Biomedical Reports

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Abstract. The aim of the present study was to evaluate the factors that affect the success rate of gonadotropin-releasing hormone antagonist on in vitro fertilization/intracytoplasmic sperm injection cycles. Multivariate analysis was performed to assess the factors that influence the outcomes, such as oocytes retrieved, and the success of pregnancy. The results showed that E 2 , P on human chorionic gonadotropin (HCG) day and body mass index (BMI) were positively correlated with the number of oocytes retrieved (P=0.001, P=0.024, P=0.017, respectively). The duration of infertility as well as the luteinizing hormone on HCG day were negatively correlated with the number of oocytes (P=0.048, P=0.002, respectively). The age of the women and P on HCG day were negatively correlated with successful pregnancy (P<0.001, P=0.022). In conclusion, some parameters, such as E 2 , P, and LH on the HCG day, as well as age and BMI, may affect treatment outcomes.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Wang

et al. 2017

Biomedical Reports

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“…However, the results reported from existing clinical studies are controversial. Some investigators have found a negative association between the probability of pregnancy and E 2 concentrations on the day of hCG administration [5][6][7][8][9]. While other studies have shown that high E 2 levels do not impair pregnancy rates [10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…For example, a total of 2,921 infertile women were grouped according to high P and high E 2 , leading to the conclusion that elevated P was detrimental to the IVF pregnancy outcome, but high serum E 2 concentrations was not [15]. Even using the same method, comparing birth outcomes between roughly stratified E 2 levels, investigators come to a different conclusion [5,9,12].…”

Section: Introductionmentioning

confidence: 99%

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Only extremely high peak serum estradiol adversely affects endometrial receptivity in IVF treatment

Song

Liao

Liu³

et al. 2019

Preprint

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Purpose To explore the effect of different concentrations of peak serum estradiol levels on endometrial receptivity quantitatively. Methods In our reproductive medicine center, two best quality of day 3 (D3) embryos were transferred or frozen according to E 2 and progesterone levels on the day of human chorionic gonadotropin (hCG) administration and the number of oocytes retrieved. The remaining embryos were cultured to blastocyst stage and frozen. The patients were then categorized into three groups. The patients with frozen-thawed D3 embryo transfer in artificial cycles without blastocyst frozen served as group 1, those with fresh D3 embryo transfer without blastocyst frozen as group 2, and those with fresh D3 embryo transfer with blastocyst frozen as group 3. Each group was further stratified into 4 sub-groups according to E 2 levels on the day of hCG administration. Clinical pregnancy rate, implantation rate and abortion rate of frozen-thawed and fresh D3 embryo transfer were compared among the three groups in the same stratified E 2 levels. Results For E 2 <7,000 pg/mL, group 1 and group 2 had similar clinical pregnancy rate and implantation rate. But for E 2 ≥7,000 pg/mL, the clinical pregnancy rate in group 1 was significantly higher than in group 2 (p<0.05). For E 2 <7,000 pg/mL, pregnancy rate and implantation rate in group 1 were significantly lower than those in group 3 (P<0.05). But for E 2 ≥7,000 pg/mL, the pregnancy rate in group 1 was significantly higher than in group 3 (P<0.05). There was no significant difference in the abortion rate between group 1 and group 2, or between group 1 and group 3. Conclusions High serum E 2 concentration does not impair implantation and pregnancy rates unless exceeding a certain limit (e.g. 7,000 pg/mL) on the day of hCG administration. Since peak E 2 level was related to OHSS and adverse pregnancy outcomes, further study is needed to set a threshold peak E 2 level for fresh embryo transfer.

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Does the elevated estradiol level on the day of human chorionic gonadotropin administration affect embryo quality among women undergoing in vitro fertilization?

Meng

Tong

Liu

2020

Intl J Gynecology & Obste

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Objective To evaluate the association between estradiol (E2) levels on the day of human chorionic gonadotropin (hCG) administration and embryo quality during in vitro fertilization (IVF) cycles. Methods A retrospective study of 6676 IVF cycles among women treated at the Reproductive Center of The First Affiliated Hospital of USTC, Hefei, China, from June 2014 to May 2017. E2 levels on hCG day were divided into four groups by 25th percentile: 0–1763 pg/mL (group I), 1763–3692 pg/mL (group II), 3692–4800 pg/mL (group III), and higher than 4800 pg/mL (group IV). Analysis of variance and multiple linear regression were used to test associations. Results There were significant differences in the frequency of high‐quality embryos between group I (51.6 ± 1.1%) and groups II (65.6 ± 0.8%), III (62.1 ± 0.7%), and IV (62.3 ± 0.7%). Using E2 as a dummy variable and group II as a control, multiple linear regression showed that E2 levels were associated with the frequency of high‐quality embryos obtained (P < 0.05). Conclusion Serum E2 on hCG day had an impact on embryo quality. Higher E2 levels did not produce the most high‐quality embryos; the highest frequencies were achieved for E2 levels within 1763–3692 pg/mL.

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Correlation of serum estradiol level on the day of ovulation trigger with the reproductive outcome of intracytoplasmic sperm injection

Cited by 17 publications

References 15 publications

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Assessing predictors for the success of GnRH antagonist protocol in reproductive women in IVF/ICSI - in fresh cycles

Only extremely high peak serum estradiol adversely affects endometrial receptivity in IVF treatment

Does the elevated estradiol level on the day of human chorionic gonadotropin administration affect embryo quality among women undergoing in vitro fertilization?

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