Correlation of serum cystatin C with inflammatory cytokines in patients with traumatic brain injury

Zou, Jingrong; Sun, Haitao; Xiang, Yang

doi:10.1002/syn.22201

Cited by 2 publications

(2 citation statements)

References 32 publications

(34 reference statements)

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“…And the contribution rate of mediating effect of brain injury severity (GCS) to the correlation between cystatin C and mortality was 26.20%, which indicated increased cystatin C level might also reflect more severe brain injury. This conclusion was consistent with findings of one previous study [ 22 ]. This study discovered that serum cystatin C concentration was negatively related with TBI severity and positively related with levels of inflammatory mediators including hsCRP (high sensitive C-reactive protein), white blood cells, and IL-6 (interlukin-6) and TNF-α (tumor necrosis factor-α) in TBI patients.…”

Section: Discussionsupporting

confidence: 94%

Serum cystatin C is correlated with mortality of traumatic brain injury patients partially mediated by acute kidney injury

Wang

Chen

et al. 2023

Acta Neurol Belg

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Background Evaluating risk of poor outcome for Traumatic Brain Injury (TBI) in early stage is necessary to make treatment strategies and decide the need for intensive care. This study is designed to verify the prognostic value of serum cystatin C in TBI patients. Methods 415 TBI patients admitted to West China hospital were included. Logistic regression was performed to explore risk factors of mortality and testify the correlation between cystatin C and mortality. Mediation analysis was conducted to test whether Acute Kidney Injury (AKI) and brain injury severity mediate the relationship between cystatin C level and mortality. Area under the receiver operating characteristic curve (AUC) was used to evaluate the prognostic value of cystatin C and the constructed model incorporating cystatin C. Results The mortality rate of 415 TBI patients was 48.9%. Non-survivors had lower GCS (5 vs 8, p < 0.001) and higher cystatin C (0.92 vs 0.71, p < 0.001) than survivors. After adjusting confounding effects, multivariate logistic regression indicated GCS ( p < 0.001), glucose ( p < 0.001), albumin ( p = 0.009), cystatin C ( p < 0.001) and subdural hematoma ( p = 0.042) were independent risk factors of mortality. Mediation analysis showed both AKI and brain injury severity exerted mediating effects on relationship between cystatin C and mortality of included TBI patients. The AUC of combining GCS with cystatin C was 0.862, which was higher than that of GCS alone ( Z = 1.7354, p < 0.05). Conclusion Both AKI and brain injury severity are mediating variables influencing the relationship between cystatin C and mortality of TBI patients. Serum cystatin C is an effective prognostic marker for TBI patients.

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Section: Discussionsupporting

confidence: 94%

Serum cystatin C is correlated with mortality of traumatic brain injury patients partially mediated by acute kidney injury

Wang

Chen

et al. 2023

Acta Neurol Belg

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“…e IL-6 concentration of patients can predict whether complications will occur, and monitoring IL-6 levels in severe patients can effectively evaluate the degree of SIRS. e level of IL-6 also reflects the severity and prognosis of the disease [21,22].…”

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confidence: 99%

Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury

Cai

2021

Emergency Medicine International

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Objective. To investigate the effect of mild hypothermia after craniotomy on the function of related organs in patients with traumatic brain injury. Method. A total of 240 patients with craniocerebral injury from January 2017 to December 2020 were retrospectively analyzed. Patients were randomly divided into a control group and an experimental group, with 120 cases in each group. The control group was treated with craniotomy decompression, and the experimental group was treated with early mild hypothermia based on craniotomy decompression. Patients’ venous blood was collected before operation (T0), at the end of operation (T1), 24 h after operation (T2), and 2 weeks after operation (T3) to detect the serum levels of the beta-subunit of S100 protein (S100-β); soluble growth stimulation expressed gene 2 (sST2), neutrophil gelatinase-associated lipocalin (NGAL), and interleukin 6 (IL-6). The prognostic effect was evaluated after 2 weeks of treatment. Results. After mild hypothermia treatment after craniotomy and decompression, the patients’ serum S100-β, sST2, NGAL, and IL-6 levels at different time points were significantly lower than the control group, and the total effective rate was higher than that of the control group. Conclusion. The treatment of mild hypothermia after craniotomy can reduce the related organs function damage indicators and inflammatory stress response, thus improving clinical efficacy and prognosis.

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Correlation of serum cystatin C with inflammatory cytokines in patients with traumatic brain injury

Abstract: Traumatic brain injury (TBI) or intracranial injury, mainly caused by external force factors, is a leading cause of death throughout the world

Cited by 2 publications

References 32 publications

Serum cystatin C is correlated with mortality of traumatic brain injury patients partially mediated by acute kidney injury

Serum cystatin C is correlated with mortality of traumatic brain injury patients partially mediated by acute kidney injury

Effect of Mild Hypothermia after Craniotomy on the Function of Related Organs in Patients with Traumatic Brain Injury

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