Correlation of serum calcium levels with severity of psoriasis

Chaudhari, Sunil; Rathi, Sushil

doi:10.18203/issn.2455-4529.intjresdermatol20184467

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…The comparison of value of serum calcium level among different severity of psoriasis cases showed significant difference among mild, moderate and severe form of psoriasis (p < 0.05). This finding is consistent with a prior study conducted by Chaudhari and Rathi (2018) [28]. In addition, the present study showed the relationship between hypocalcaemia with different types of psoriasis (p < 0.05).…”

Section: Discussionsupporting

confidence: 94%

Hypocalcaemia Among Patients With Psoriatic Disease; A Cross-Sectional Study Among Patients From BSMMU

Akter¹,

Khondker²,

Haque³

et al. 2020

TAJMSPR

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Psoriasis is a common, chronic, immune mediated inflammatory disease that involves the innate immunological system and acquired immunological system. Intracellular calcium plays an important part in the regulation of proliferation and differentiation of keratinocytes. This study tried to identify the correlation between severity of disease and serum calcium level in psoriasis patients. To assess the serum calcium level in patients of different types of psoriasis and to find out its relationship with disease severity according to Psoriasis Area Severity Index (PASI).This cross sectional study was conducted among purposively selected 45 patients in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka who had psoriasis on the basis of history, clinical findings and laboratory report. Regardless of gender, the age ranging from 18-65 years and having no calcium metabolism disorder or impaired renal function were the selection criteria of study participants. All patients were interviewed by Pre-structured questionnaire. Blood sample (5 ml) was collected from each subject and was preserved and analyzed for serum calcium level by the automated analyzer i.e. Beckman Coulter-AU680 in the Department of Biochemistry, BSMMU. Age range of the participants were 18 to 65 years (mean age=34.1±12.1 years). Maximum 26 (57.8%) patients had normal calcium level, 19 (42.2%) patients had hypocalcaemia and no patient was found with hypercalcaemia. As observed, hypocalcemia frequency is high in more severe types of psoriasis. Hypocalcaemia was found among all types of psoriatic patients'. The correlation between PASI and

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Section: Discussionsupporting

confidence: 94%

Hypocalcaemia Among Patients With Psoriatic Disease; A Cross-Sectional Study Among Patients From BSMMU

Akter¹,

Khondker²,

Haque³

et al. 2020

TAJMSPR

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“…Chaudhari et al 23 also found a significant reduction in serum calcium levels in patients of psoriasis vulgaris compared to control group, but they could not demonstrate a statistically significant association of hypocalcaemia with severity of psoriasis. Gisondi et al 24 and Nayak et al 25 also conducted studies on psoriasis vulgaris only, but they failed to demonstrate any association with hypocalcaemia.…”

Section: Discussionmentioning

confidence: 89%

Correlation of hypocalcaemia with severity and type of psoriasis: A cross-sectional study

Maheswari¹,

Dutta²

2021

IJCED

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Psoriasis is a common dermatological disorder with many risk factors including low calcium levels. The improvement of psoriasis with calcium and Vitamin D3 analogues can implicate a role of calcium levels in triggering or aggravating psoriasis by controlling the proliferation and differentiation of keratinocytes. The objective is to study the calcium levels in various types of psoriasis and to find any correlation between calcium levels and severity of psoriasis. Cross sectional observational study Serum calcium and albumin levels of all psoriatic patients meeting the inclusion criteria were assessed. PASI score was calculated for patients with psoriasis vulgaris. SPSS software, version 21.0 was used. Chi-square test used for significance of study parameters on categorical scale [significance was assessed at 5% level of significance] and Pearson test was used to find correlation. The study included 206 patients of various forms of psoriasis over the period of 1 year, with males outnumbering females. Hypocalcaemia was found in 18.45% of patients, with significant association of hypocalcaemia in psoriasis vulgaris, pustular psoriasis and erythroderma. A moderately strong negative correlation was found between severity of psoriasis vulgaris and serum calcium levels. Association of hypocalcaemia with severe forms of psoriasis can indicate the role of oral or dietary supplements to correct serum calcium levels to prevent the progression of mild, stable forms of disease to severe forms and thus provide a better outcome.

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“…Chaudhari S et al [13] analyzed serum calcium levels in patients of psoriasis and correlated with severity of psoriasis in comparison with control subjects. They observed the same that mean Serum calcium levels were significantly lower in psoriasis patients than in controls.…”

Section: Discussionmentioning

confidence: 99%

“…PASI (Psoriatic Area Severity Index) Scoring index was used to evaluate the severity of the disease and categorized into mild (PASI <10), moderate (PASI 10-20) and severe (PASI >20). [13] Data Processing and Statistical Analysis: A packaged computer analysis program, statistical package for the social science (IBM SPSS statisticsVersion20) will be using for statistical analysis of this data. Chi-square test was used to find the significance of study parameters on categorical scale and Pearson test was used to find correlation.…”

Section: Size Of Samplementioning

confidence: 99%

تقييم مستوى الكالسيوم المصلي عند مرضى الصداف

جمعة¹,

إسماعيل²,

خدّام³

2022

Journal of Medical and Pharmaceutical Sciences

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Background: Psoriasis is a chronic immune- mediated skin disease, with a genetic predisposition. Many factors can trigger or exacerbate psoriasis. Recently, some studies found that psoriasis was associated with hypocalcemia. So we did this study to find this association in our patients. Objective: To evaluate serum calcium level in psoriatic patients and compare it with controls. Methods: This case- control study included 160 subjects (80 patients with psoriasis and 80 controls) admitted to dermatology clinic at Tishreen University Hospital, Latakia, Syria, from 2020- 2021. Serum calcium and serum albumin levels were estimated in all patients. Results: Calcium levels were significantly lower in psoriatic patients than in the control group (mean = 8.98±0.5 in patients vs 9.48±0.5 in controls, p- value<0.001). Calcium levels were significantly lower in patients with severe types of psoriasis (p- value<0.05). There was an inverse correlation between serum calcium levels and PASI score (r =- 0.3, p- value<0.05). There was also an inverse correlation between serum calcium levels and each of age and disease duration. Conclusion: In this study, a low calcium level was observed in psoriatic patients. Hypocalcemia may be a marker for the severity of psoriasis. In addition, Calcium seems to have a role in the pathogenesis of psoriasis.

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Correlation of serum calcium levels with severity of psoriasis

Cited by 6 publications

References 9 publications

Hypocalcaemia Among Patients With Psoriatic Disease; A Cross-Sectional Study Among Patients From BSMMU

Hypocalcaemia Among Patients With Psoriatic Disease; A Cross-Sectional Study Among Patients From BSMMU

Correlation of hypocalcaemia with severity and type of psoriasis: A cross-sectional study

تقييم مستوى الكالسيوم المصلي عند مرضى الصداف

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