Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjögren's syndrome

Zhang, Hairong; Ye, Hongling; Xu, Zhiye; Dong, Kunzhan; Wang, Ying; Geng, Linyu; Wang, Sen

doi:10.1016/j.imlet.2023.04.010

Cited by 2 publications

(2 citation statements)

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“…In autoimmune diseases like SLE and SS, serum ADA activity is elevated and associated with disease activity. 11 , 13 Patients with AOSD also show increased ADA activity, suggesting its role as a potential biomarker for AOSD diagnosis. 12 These findings imply that under pathological conditions, abnormal ADA activity correlates with immune dysregulation.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated ADA levels and activity are observed in various tumors, including gastric, bladder, and breast cancers . Similarly, increased ADA activity is associated with disease activity in autoimmune conditions such as systemic lupus erythematosus (SLE), adult-onset Still’s disease (AOSD), and Sjögren’s syndrome (SS). − Additionally, high ADA activity in pleural fluid is a key diagnostic criterion for tuberculosis. , …”

Section: Introductionmentioning

confidence: 99%

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Adenosine Deaminase as a Potential Diagnostic and Prognostic Biomarker for Severe Fever with Thrombocytopenia Syndrome

Ye,

Lin,

Zhang

et al. 2024

ACS Omega

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Background: Severe fever with thrombocytopenia syndrome (SFTS) is a serious infectious disease caused by the Dabie bandavirus, with a high mortality rate. Currently, there are no effective vaccines or specific treatments for SFTS. Early diagnosis and accurate severity assessment are crucial. Methods: This study included 171 cases of SFTS, COVID-19, and hepatitis B virus (HBV) patients and healthy controls. We compared the serum adenosine deaminase (ADA) activity across these groups. The diagnostic and prognostic efficiency of serum ADA for SFTS was evaluated by using receiver operating characteristic (ROC) curve analysis. We also examined the correlation between serum ADA in SFTS patients and clinical lab parameters as well as serum cytokines. Results: SFTS patients had significantly higher serum ADA activity than those of COVID-19, HBV patients, and healthy controls. Nonsurvivor SFTS patients had notably higher ADA than survivors. ROC analysis indicated ADA as an effective SFTS diagnostic and prognostic biomarker. ADA correlated with prognosis, viral load, APTT, PT, AST, ferritin, negatively with HDL-c and LDL-c, and positively with cytokines like IL-6, TNF-α, and IL-1β. Multiorgan failure patients showed significant ADA increase. Conclusion: Elevated serum ADA activity in SFTS patients is linked with disease severity and prognosis, showing potential as a diagnostic and prognostic biomarker for SFTS.

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Section: Discussionmentioning

confidence: 99%