Correlation of Risk Scores with Coronary Anatomy in Non-ST-elevation Acute Coronary Syndrome

Santos, Elizabete Silva dos; Filho, Luciano de Figueiredo Aguiar; Fonseca, Daniela Menezes; Londero, Hugo José; Xavier, Rogério Martins; Pereira, Marcos Paulo Torres; Minuzzo, Luiz; Souza, Roberta de Castro; Timerman, Ari

doi:10.5935/abc.20130088

Cited by 15 publications

(26 citation statements)

References 19 publications

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“…Ischemic heart disease is a leading cause of death worldwide and acute coronary ischemia is responsible for the largest number (Santos et al, 2013). Elevated circulating LDL levels increase risk for ischemic cerebro-and cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

Xu¹,

Zheng²,

Zhang³

et al. 2014

Vascular Pharmacology

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Section: Discussionmentioning

confidence: 99%

Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

Xu¹,

Zheng²,

Zhang³

et al. 2014

Vascular Pharmacology

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“…7 The risk stratification is important as it has been consistently proved that early coronary intervention in high-risk patients improves clinical outcomes. The main focus of this strategy is to evaluate the probability of occurrence of adverse events, analyzing data from the clinical history, physical examination, ECG findings and cardiac biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

et al. 2017

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Introduction:Cardiovascular diseases account for more than 17 million deaths globally each year. This figure is expected to grow to 23.6 million by the year 2030. Coronary artery disease alone caused 7 million deaths worldwide in 2010 and it is an increase of 35% since 1990. 1 The incidence of non-ST elevation acute coronary syndrome to ST elevation myocardial infarction is increasing, probably as a result of demographic changes in the population, including progressively increasing numbers of older persons and higher rates of diabetes mellitus. 2 NSTEMI currently accounts for about 50% of all myocardial infarctions. With the increased use of beta blockers and aspirin the incidence of NSTEMI is increasing. 3 The 6-month mortality rate in the patients with NSTEMI is about 6.2% and re-hospitalization rates over the 6 month is about 20%. This type of prognosis in patients with NSTEMI can be assessed by early risk stratification. Several risk scores are developed in predicting the outcomes in patients with acute coronary syndrome including NSTEMI. The most popular risk scores are the GRACE and TIMI risk scores. These risk scores calculate the patient's risk of mortality which depends on the severity of coronary artery disease and other comorbid conditions. But estimating the possible severity of coronary artery disease by these scores before performing coronary angiography may change the therapeutic decision and the timing or intensity of interventions.

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“…Moreover, the relationship between TRS and the severity of CAD has been shown in several studies. TRS was compared with the results of coronary angiography in 683 patients with NSTE-ACS; for each increased risk category, the 3-vessel disease was shown to be more frequent (1). In the PRISM-PLUS study of 1491 patients with ACS, it was shown that there were more severe coronary lesions and left main coronary lesions in patients with high TRS compared with those with low TRS (45).…”

Section: Reflow No-reflow P Valuementioning

confidence: 99%

“…This index has been shown to be useful and helpful in many studies (15,16). Many studies have investigated the relationship between GRS, TRI, and ACS (1,(17)(18)(19), but none have addressed the association between TRI, TRS, GRS, and NRF in patients with STEMI. We investigated whether preintervention TRI, TRS, and GRS are related to coronary NRF in patients with STEMI who underwent primary percutaneous coronary intervention (p-PCI).…”

Section: Introductionmentioning

confidence: 99%

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The utility of the TIMI risk index on admission for predicting angiographic no-reflow after primary percutaneous coronary intervention in patients with STEMI

Acet¹,

Ertaş²,

Akıl³

et al. 2016

Turk J Med Sci

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Background/aim: The thrombolysis in myocardial infarction (TIMI) risk score (TRS), and the TIMI risk index (TRI) have been reported in coronary artery disease patients. We investigated whether admission TRI is associated with no-reflow (NRF) in patients undergoing primary percutaneous coronary intervention (p-PCI).Materials and methods: ST-segment elevation myocardial infarction (STEMI) patients treated with p-PCI were included in the study. TRI was calculated on admission using specified variables. We defined the angiographic NRF phenomenon as a coronary TIMI flow grade of ≤2 after the vessel was recanalized or a TIMI flow grade of 3 together with a final myocardial blush grade (MBG) of <2 in a manner as described in previous studies.Results: A total of 371 patients (aged 62 ± 14 years; 73/27 men to women ratio) who underwent p-PCI were enrolled in the study. In terms of age, NRF patients were older than reflow patients (P < 0.017 for MBG). Killip class III-IV designations were more common in NRF patients (P = 0.029 for MBG). TRI (P = 0.014 for MBG) values were significantly greater in the NRF group. TRI was an independent predictor of NRF according to MBG flow (P = 0.003, B = -0.035, Exp B = 0966, 95% CI, 0.944-0.988). Conclusion:Admission TRI may predict the development of NRF phenomenon after p-PCI in patients with acute STEMI.

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Correlation of Risk Scores with Coronary Anatomy in Non-ST-elevation Acute Coronary Syndrome

Abstract: Risk scores correlate with the severity of coronary lesions, and the TIMI risk score showed the best predictive ability.

Cited by 15 publications

References 19 publications

Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

Low density lipoprotein induces upregulation of vasoconstrictive endothelin type B receptor expression

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

The utility of the TIMI risk index on admission for predicting angiographic no-reflow after primary percutaneous coronary intervention in patients with STEMI

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